| Identification |
|---|
| BMDB Protein ID
| BMDBP01822 |
| Secondary Accession Numbers
| None |
| Name
| Thyrotropin receptor |
| Synonyms
|
Not Available
|
| Gene Name
| TSHR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein-hormone receptor activity |
| Specific Function
| Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| TSHR |
| Gene Sequence
|
>2292 bp
ATGCGGCCGACGCCCCTCCTGCGGCTGGCGCTGTTTCTGGTCCTGCCCAGCAGCCTCGGT
GGGGAGAGGTGTCCGTCTCCGCCCTGCGAATGCCGCCAGGAGGACGACTTCAGAGTCACC
TGCAAGGACATCCAGAGCATCCCTAGCTTACCCCCCAGCACGCAGACCCTGAAGTTTATA
GAGACTCATCTGAAAACCATTCCCAGTCGTGCGTTCTCAAATCTGCCCAATATTTCCAGG
ATCTACTTGTCAATAGATGCAACTCTGCAGCAGCTGGAATCACATTCCTTCTACAATTTA
AGTAAAGTGACTCACATAGAGATTCGGAATACCAGAAGTTTAACTTACATAGACTCTGGC
GCCCTAAAAGAGCTCCCCCTTCTAAAGTTCCTTGGCATTTTCAACACTGGACTTAGAGTA
TTCCCCGACCTGACCAAAATCTATTCCACCGATGTGTTCTTCATACTTGAAATTACAGAC
AACCCTTACATGACTTCAATCCCTGCGAATGCTTTTCAGGGCCTGTGCAACGAAACCTTG
ACACTGAAGCTATACAACAATGGCTTTACTTCAATCCAAGGACATGCTTTCAACGGGACA
AAGCTGGATGCTGTTTACCTGAACAAGAATAAATACCTGACAGTCATCGGCCAAGATGCA
TTTGCAGGGGTCTATAGCGGACCAACCTTGCTGGACATCTCTTATACCAGTGTCACAGCC
CTACCATCCAAAGGCCTGGAACACCTGAAGGAATTGATAGCAAGAAACACTTGGACTCTA
AGGAAACTTCCTCTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTATCCG
AGCCACTGCTGCGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTCAGTCTTTAATG
TGTAACGAGAGCAGTATTCGGGGCCTGCGTCAGAGAAAATCCGCAAGTGCTTTGAATGGT
CCCTTCTACCAGGAATATGAGGATCTGGGTGATGGCAGTGCTGGGTACAAGGAGAACTCC
AAGTTCCAAGATACCCAAAGCAACTCTCATTACTATGTCTTCTTTGAGGAGCAAGAAGAT
GAGATCATCGGTTTTGGCCAACAGCTCAAAAACCCCCAGGAGGAGACCCTGCAGGCCTTT
GACAGCCATTACGACTATACCGTGTGTGGGGGCAGTGAGGACATGGTGTGTACCCCCAAG
TCGGATGAGTTCAACCCCTGTGAGGACATCATGGGCTACAAGTTCCTGAGAATCGTGGTG
TGGTTTGTGAGTCTGCTGGCTCTCCTGGGCAACGTCTTCGTCCTGGTCATCCTCCTCACG
AGCCACTACAAGCTGACCGTCCCACGCTTCCTCATGTGCAACCTGGCCTTTGCAGACTTC
TGCATGGGGTTGTATCTGCTCCTCATCGCCTCCGTAGACCTCTACACTCAGTCTGAGTAC
TACAACCATGCCATTGACTGGCAGACAGGCCCTGGCTGCAACACAGCTGGCTTCTTCACC
GTCTTTGCCAGCGAGCTGTCTGTGTACACGCTGACGGTCATCACCTTGGAGCGCTGGCAC
GCCATCACCTTCGCCATGCGCCTGGACCGCAAGATCCGCCTCTGGCACGCCTATGTCATC
ATGCTGGGGGGCTGGGTTTGCTGCTTCCTGCTCGCCCTGCTCCCTTTGGTGGGAATAAGC
AGCTATGCCAAGGTCAGCATCTGCCTGCCCATGGACACCGAGACTCCTCTTGCCCTGGCG
TACATTATCCTTGTTCTGTTACTCAACATCATTGCCTTTATCATCGTCTGTGCCTGTTAC
GTGAAGATCTACATCACAGTCCGAAATCCCCACTACAACCCGGGGGACAAAGATACCAGA
ATTGCCAAAAGGATGGCTGTGTTGATCTTCACTGACTTCATGTGCATGGCCCCAATCTCT
TTCTACGCTCTGTCGGCCCTTATGAACAAGCCTCTCATCACCGTTACCAATTCCAAAATC
TTGCTGGTCCTCTTCTACCCACTTAACTCCTGTGCCAATCCATTCCTCTATGCCATTTTC
ACCAAAGCCTTCCAGAGGGATGTGTTTATGCTGCTCAGCAAGTTTGGCATCTGTAAACGC
CAGGCTCAGGCATACCGGGGTCAGAGAGTTTCTCCAAAGAACAGCACTGGTATTCGGGTC
CAAAAGGTTCCCCCAGATGTGAGGCAGAGTCTCCCCAATGTGCAGGATGACTATGAGCTG
CTTGAAAACTCTCATCTAACCCCAAAGCAGCAGGACCAAACCTCAAAAGAGTATAAGCGA
ACAGTTTTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 763 |
| Molecular Weight
| 86431.0 |
| Theoretical pI
| 8.13 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 413-440
- 450-472
- 494-516
- 537-559
- 580-601
- 625-648
- 660-681
|
| Protein Sequence
|
>Thyrotropin receptor
MRPTPLLRLALFLVLPSSLGGERCPSPPCECRQEDDFRVTCKDIQSIPSLPPSTQTLKFI
ETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESHSFYNLSKVTHIEIRNTRSLTYIDSG
ALKELPLLKFLGIFNTGLRVFPDLTKIYSTDVFFILEITDNPYMTSIPANAFQGLCNETL
TLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTVIGQDAFAGVYSGPTLLDISYTSVTA
LPSKGLEHLKELIARNTWTLRKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILQSLM
CNESSIRGLRQRKSASALNGPFYQEYEDLGDGSAGYKENSKFQDTQSNSHYYVFFEEQED
EIIGFGQQLKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYKFLRIVV
WFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSEY
YNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWHAITFAMRLDRKIRLWHAYVI
MLGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIIAFIIVCACY
VKIYITVRNPHYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKI
LLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGQRVSPKNSTGIRV
QKVPPDVRQSLPNVQDDYELLENSHLTPKQQDQTSKEYKRTVL
|
| External Links |
|---|
| GenBank ID Protein
| AAC18639.1 |
| UniProtKB/Swiss-Prot ID
| Q27987 |
| UniProtKB/Swiss-Prot Entry Name
| TSHR_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U15570 |
| GeneCard ID
| TSHR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
