Showing Protein Thyrotropin receptor (BMDBP01822)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01822 |
| Secondary Accession Numbers | None |
| Name | Thyrotropin receptor |
| Synonyms | Not Available |
| Gene Name | TSHR |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in protein-hormone receptor activity |
| Specific Function | Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | TSHR |
| Gene Sequence |
>2292 bp ATGCGGCCGACGCCCCTCCTGCGGCTGGCGCTGTTTCTGGTCCTGCCCAGCAGCCTCGGT GGGGAGAGGTGTCCGTCTCCGCCCTGCGAATGCCGCCAGGAGGACGACTTCAGAGTCACC TGCAAGGACATCCAGAGCATCCCTAGCTTACCCCCCAGCACGCAGACCCTGAAGTTTATA GAGACTCATCTGAAAACCATTCCCAGTCGTGCGTTCTCAAATCTGCCCAATATTTCCAGG ATCTACTTGTCAATAGATGCAACTCTGCAGCAGCTGGAATCACATTCCTTCTACAATTTA AGTAAAGTGACTCACATAGAGATTCGGAATACCAGAAGTTTAACTTACATAGACTCTGGC GCCCTAAAAGAGCTCCCCCTTCTAAAGTTCCTTGGCATTTTCAACACTGGACTTAGAGTA TTCCCCGACCTGACCAAAATCTATTCCACCGATGTGTTCTTCATACTTGAAATTACAGAC AACCCTTACATGACTTCAATCCCTGCGAATGCTTTTCAGGGCCTGTGCAACGAAACCTTG ACACTGAAGCTATACAACAATGGCTTTACTTCAATCCAAGGACATGCTTTCAACGGGACA AAGCTGGATGCTGTTTACCTGAACAAGAATAAATACCTGACAGTCATCGGCCAAGATGCA TTTGCAGGGGTCTATAGCGGACCAACCTTGCTGGACATCTCTTATACCAGTGTCACAGCC CTACCATCCAAAGGCCTGGAACACCTGAAGGAATTGATAGCAAGAAACACTTGGACTCTA AGGAAACTTCCTCTTTCCTTGAGTTTCCTTCACCTCACACGGGCTGACCTTTCTTATCCG AGCCACTGCTGCGCTTTTAAGAATCAGAAGAAAATCAGAGGAATCCTTCAGTCTTTAATG TGTAACGAGAGCAGTATTCGGGGCCTGCGTCAGAGAAAATCCGCAAGTGCTTTGAATGGT CCCTTCTACCAGGAATATGAGGATCTGGGTGATGGCAGTGCTGGGTACAAGGAGAACTCC AAGTTCCAAGATACCCAAAGCAACTCTCATTACTATGTCTTCTTTGAGGAGCAAGAAGAT GAGATCATCGGTTTTGGCCAACAGCTCAAAAACCCCCAGGAGGAGACCCTGCAGGCCTTT GACAGCCATTACGACTATACCGTGTGTGGGGGCAGTGAGGACATGGTGTGTACCCCCAAG TCGGATGAGTTCAACCCCTGTGAGGACATCATGGGCTACAAGTTCCTGAGAATCGTGGTG TGGTTTGTGAGTCTGCTGGCTCTCCTGGGCAACGTCTTCGTCCTGGTCATCCTCCTCACG AGCCACTACAAGCTGACCGTCCCACGCTTCCTCATGTGCAACCTGGCCTTTGCAGACTTC TGCATGGGGTTGTATCTGCTCCTCATCGCCTCCGTAGACCTCTACACTCAGTCTGAGTAC TACAACCATGCCATTGACTGGCAGACAGGCCCTGGCTGCAACACAGCTGGCTTCTTCACC GTCTTTGCCAGCGAGCTGTCTGTGTACACGCTGACGGTCATCACCTTGGAGCGCTGGCAC GCCATCACCTTCGCCATGCGCCTGGACCGCAAGATCCGCCTCTGGCACGCCTATGTCATC ATGCTGGGGGGCTGGGTTTGCTGCTTCCTGCTCGCCCTGCTCCCTTTGGTGGGAATAAGC AGCTATGCCAAGGTCAGCATCTGCCTGCCCATGGACACCGAGACTCCTCTTGCCCTGGCG TACATTATCCTTGTTCTGTTACTCAACATCATTGCCTTTATCATCGTCTGTGCCTGTTAC GTGAAGATCTACATCACAGTCCGAAATCCCCACTACAACCCGGGGGACAAAGATACCAGA ATTGCCAAAAGGATGGCTGTGTTGATCTTCACTGACTTCATGTGCATGGCCCCAATCTCT TTCTACGCTCTGTCGGCCCTTATGAACAAGCCTCTCATCACCGTTACCAATTCCAAAATC TTGCTGGTCCTCTTCTACCCACTTAACTCCTGTGCCAATCCATTCCTCTATGCCATTTTC ACCAAAGCCTTCCAGAGGGATGTGTTTATGCTGCTCAGCAAGTTTGGCATCTGTAAACGC CAGGCTCAGGCATACCGGGGTCAGAGAGTTTCTCCAAAGAACAGCACTGGTATTCGGGTC CAAAAGGTTCCCCCAGATGTGAGGCAGAGTCTCCCCAATGTGCAGGATGACTATGAGCTG CTTGAAAACTCTCATCTAACCCCAAAGCAGCAGGACCAAACCTCAAAAGAGTATAAGCGA ACAGTTTTGTAA |
| Protein Properties | |
| Number of Residues | 763 |
| Molecular Weight | 86431.0 |
| Theoretical pI | 8.13 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Thyrotropin receptor MRPTPLLRLALFLVLPSSLGGERCPSPPCECRQEDDFRVTCKDIQSIPSLPPSTQTLKFI ETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESHSFYNLSKVTHIEIRNTRSLTYIDSG ALKELPLLKFLGIFNTGLRVFPDLTKIYSTDVFFILEITDNPYMTSIPANAFQGLCNETL TLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTVIGQDAFAGVYSGPTLLDISYTSVTA LPSKGLEHLKELIARNTWTLRKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILQSLM CNESSIRGLRQRKSASALNGPFYQEYEDLGDGSAGYKENSKFQDTQSNSHYYVFFEEQED EIIGFGQQLKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYKFLRIVV WFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGLYLLLIASVDLYTQSEY YNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWHAITFAMRLDRKIRLWHAYVI MLGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIIAFIIVCACY VKIYITVRNPHYNPGDKDTRIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKI LLVLFYPLNSCANPFLYAIFTKAFQRDVFMLLSKFGICKRQAQAYRGQRVSPKNSTGIRV QKVPPDVRQSLPNVQDDYELLENSHLTPKQQDQTSKEYKRTVL |
| External Links | |
| GenBank ID Protein | AAC18639.1 |
| UniProtKB/Swiss-Prot ID | Q27987 |
| UniProtKB/Swiss-Prot Entry Name | TSHR_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | U15570 |
| GeneCard ID | TSHR |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |