| Identification |
|---|
| BMDB Protein ID
| BMDBP01832 |
| Secondary Accession Numbers
| None |
| Name
| Interferon tau-1 |
| Synonyms
|
Not Available
|
| Gene Name
| IFNT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cytokine activity |
| Specific Function
| Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q15 |
| SNPs
| IFNT1 |
| Gene Sequence
|
>588 bp
ATGGCCTTCGTGCTCTCTCTACTGATGGCCCTGGTGCTGGTCAGCTACGGCCAGGGACGA
TCTCTGGGTTGTTACCTGTCTGAGGACCACATGCTAGGTGCCAGGGAGAACCTCAGGCTC
CTGGCCCGAATGAACAGACTCTCTCCTCATCCCTGTCTGCAGGACAGAAAAGACTTTGGT
CTTCCTCAGGAGATGGTGGAGGGCAACCAGCTCCAGAAGGATCAGGCTATCTCTGTGCTC
CACGAGATGCTCCAGCAGTGCCTCAACCTCTTCTACACAGAGCACTCGTCTGCTGCCTGG
AACACCACCCTCCTGGAGCAGCTCTGCACTGGGCTCCAACAGCAGCTGGAGGACCTGGAC
GCCTGCCTGGGCCCAGTGATGGGAGAGAAAGACTCTGACATGGGAAGGATGGGCCCCATT
CTGACTGTGAAGAAGTACTTCCAGGGTATCCATGTCTACCTGAAAGAAAAAGAATACAGT
GACTGCGCCTGGGAAATCATCAGAGTGGAGATGATGAGAGCCCTCTCTTCATCAACCACC
TTGCAAAAAAGGTTAAGAAAGATGGGTGGAGATCTGAACTCACTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 195 |
| Molecular Weight
| 22134.0 |
| Theoretical pI
| 6.35 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Interferon tau-1
MAFVLSLLMALVLVSYGPGRSLGCYLSEDHMLGARENLRLLARMNRLSPHPCLQDRKDFG
LPQEMVEGNQLQKDQAISVLHEMLQQCFNLFYTEHSSAAWNTTLLEQLCTGLQQQLEDLD
ACLGPVMGEKDSDMGRMGPILTVKKYFQGIHVYLKEKEYSDCAWEIIRVEMMRALSSSTT
LQKRLRKMGGDLNSL
|
| External Links |
|---|
| GenBank ID Protein
| AAA50458.2 |
| UniProtKB/Swiss-Prot ID
| P15696 |
| UniProtKB/Swiss-Prot Entry Name
| IFNT1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M31557 |
| GeneCard ID
| IFNT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
