| Identification |
|---|
| BMDB Protein ID
| BMDBP01837 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-aminobutyric acid receptor subunit pi |
| Synonyms
|
Not Available
|
| Gene Name
| GABRP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| Not Available |
| SNPs
| GABRP |
| Gene Sequence
|
>1323 bp
ATGAAGCGCAGTCTCCACCTGACCTTCGTGTGTCTGAGTCTCTTCTCTGCACGGATGTGC
GTCCAGGGGAATCAGTTTAACATCGAGGTCAGCAGAAGCAACAAGCTGTCCCTGCCTGGC
TTTGAGAATCTCACAGCAGGATATAACAAGTTTCTCAGGCCCAATTTTGGCGGAGAACCT
GTTCAGATAGCACTGACTCTGGACGTTGCAAGTATTTCCAGTATTTCAGAGAGTAATATG
GACTACACAGCCACCATATACCTCAGACAGCGCTGGACGGACCAGCGGCTGGTGTTTGAA
GGCAACAAGAGCTTCACTCTGGATGCACGCCTAGTGGAATTCCTCTGGGTGCCAGACACC
TACATCGTGGAGTCCAAGAAGTCCTTCCTCCATGAAGTCACTGTGGGGAACAGACTTATC
CGCCTCTTCTCCAATGGCACAGTCCTGTATGCCCTCAGAATCACAACAACTGTTGCATGT
AACATGGACCTGTCTAAATACCCCATGGACACACAGACATGCAAGTTGCAACTAGAGAGC
TGGGGCTACGATGGGAATGACGTAGAGTTCAGCTGGCTGAGAGGGAACGACTCTGTGCGG
GGACTGGAGAACCTGCGGCTTGCTCAGTACACCATACAACAATATTTCACCTCAGTTACC
AGATCACAGCAGGAAACAGGAAATTACACACGACTGGTCTTGCAATTTGAGCTTCAGAGG
AACGTCCTGTATTTCATTTTGGAAACCTATGTTCCTTCCACTTTCCTGGTGGTGTTATCC
TGGGTCTCGTTTTGGATCTCCCTTGACTCAGTTCCTGCAAGAACCTGCATTGGAGTGACC
ACCGTATTGTCAATGACCACACTGATGATTGGGTCCCGTACTTCTCTCCCGAACACCAAC
TGCTTCATAAAGGCCATCGATGTGTACCTGGGAATATGCTTTAGCTTCGTGTTTGGGGCC
CTCCTGGAATATGCAGTTGCCCACTACAGCTCCTTACAGCAGATGGCAGCCAAAGATCGG
GGGAAAGCAAAGGAAGTGGAAGAAGTCAACATTACTAACATCATCAACAGCTCCATCTCC
AGCTTTAAACGGAAGATCAGTTTTGCCAGCATTGAAATTTCCGGAGATAACGTTGACTAC
AGCGACCTGACAATGAAAACCAGTGACAAGGTCAAGTTTGTCTTCCGAGATAAGTTGGGC
AGGATTGTTGATTATTTCACAATTCAAAACCCGAGTAATGTTGATCGATATTCCAAACTA
CTATTTCCTTTGATTTTTATGCTAGCCAATGTATTTTACTGGGCATACTATATGTATTTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 440 |
| Molecular Weight
| 50430.0 |
| Theoretical pI
| 8.41 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 243-266
- 270-292
- 305-327
- 417-438
|
| Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit pi
MKRSLHLTFVCLSLFSARMCVQGNQFNIEVSRSNKLSLPGFENLTAGYNKFLRPNFGGEP
VQIALTLDVASISSISESNMDYTATIYLRQRWTDQRLVFEGNKSFTLDARLVEFLWVPDT
YIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLES
WGYDGNDVEFSWLRGNDSVRGLENLRLAQYTIQQYFTSVTRSQQETGNYTRLVLQFELQR
NVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTN
CFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGKAKEVEEVNITNIINSSIS
SFKRKISFASIEISGDNVDYSDLTMKTSDKVKFVFRDKLGRIVDYFTIQNPSNVDRYSKL
LFPLIFMLANVFYWAYYMYF
|
| External Links |
|---|
| GenBank ID Protein
| AAX08780.1 |
| UniProtKB/Swiss-Prot ID
| Q5EA06 |
| UniProtKB/Swiss-Prot Entry Name
| GBRP_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020763 |
| GeneCard ID
| GABRP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
