| Identification |
|---|
| BMDB Protein ID
| BMDBP01848 |
| Secondary Accession Numbers
| None |
| Name
| Glycine receptor subunit alpha-1 |
| Synonyms
|
Not Available
|
| Gene Name
| GLRA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride ion binding |
| Specific Function
| Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability (PubMed:11178872). Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| GLRA1 |
| Gene Sequence
|
>1374 bp
ATGTACAGCTTCAATACTCTTCGACTCTACCTTTGGGAGACCATTGTATTCTTCAGTCTT
GCTGCTTCCAAGGAGGCTGAAGCTGCTCGGTCTGCTTCCAAGCCCATGTCACCGTCCGAT
TTCCTGGATAAACTCATGGGGAGGACTTCTGGATACGACGCCAGGATCAGGCCCAATTTC
AAAGGTCCCCCAGTGAATGTCAGCTGCAACATTTTCATCAACAGCTTCGGTTCCATTGCT
GAGACAACTATGGACTACAGGGTCAACATCTTCCTGCGGCAGCAGTGGAATGACCCCCGG
CTGGCCTACAATGAATACCCCGATGACTCGCTGGACTTGGACCCATCCATGTTGGACTCC
ATCTGGAAACCTGACCTGTTCTTTGCCAATGAGAAGGGGGCCCACTTCCATGAGATCACC
ACAGACAACAAACTGCTGAGGATCTCCCGGAACGGGAATGTCCTCTACAGCATTAGGATC
ACCCTGACATTGGCCTGCCCCATGGACTTGAAGAATTTCCCCATGGATGTCCAGACGTGC
ATTATGCAACTGGAAAGCTTTGGATACACCATGAACGACCTCATCTTTGAGTGGCAGGAG
CAGGGGGCTGTGCAGGTGGCAGATGGACTAACTCTACCCCAGTTTATCCTGAAAGAGGAG
AAGGACTTGAGATACTGCACCAAGCATTACAACACAGGCAAATTCACCTGCATCGAGGCC
CGGTTCCACCTGGAGCGACAGATGGGCTACTACCTGATCCAGATGTACATCCCCAGCCTG
CTCATTGTCATCCTCTCGTGGATCTCCTTCTGGATCAACATGGATGCTGCTCCCGCCCGT
GTGGGCCTGGGCATCACCACTGTGCTCACCATGACCACCCAGAGCTCCGGCTCTCGAGCA
TCCCTGCCCAAGGTATCGTATGTGAAGGCCATCGACATTTGGATGGCCGTGTGCCTGCTC
TTTGTGTTCTCAGCCCTGCTTGAGTACGCCGCCGTCAACTTTGTGTCTCGGCAGCACAAA
GAGCTGCTCCGATTCAGGAGGAAGCGAAGACATCACAAGAGCCCCATGTTGAATCTGTTC
CAGGAGGATGAGGCTGGAGAGGGCCGCTTCAACTTCTCGGCCTACGGCATGGGCCCAGCC
TGCCTTCAGGCCAAGGATGGCATCTCTGTCAAGGGCGCCAACAACAGCAACACGACCAAC
CCTCCTCCGGCACCATCCAAGTCCCCGGAGGAGATGCGAAAACTCTTCATCCAGCGGGCC
AAGAAGATCGACAAGATCTCCCGCATCGGCTTCCCCATGGCCTTCCTCATCTTCAACATG
TTCTACTGGATCATCTACAAAATCGTCCGCAGGGAGGACGTCCACAACCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 457 |
| Molecular Weight
| 52614.0 |
| Theoretical pI
| 9.04 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 251-272
- 278-298
- 310-330
- 426-446
|
| Protein Sequence
|
>Glycine receptor subunit alpha-1
MYSFNTLRLYLWETIVFFSLAASKEAEAARSASKPMSPSDFLDKLMGRTSGYDARIRPNF
KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS
IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA
RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA
SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF
QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA
KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
|
| External Links |
|---|
| GenBank ID Protein
| AAG14346.1 |
| UniProtKB/Swiss-Prot ID
| P57695 |
| UniProtKB/Swiss-Prot Entry Name
| GLRA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF268375 |
| GeneCard ID
| GLRA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
