Showing Protein Glycine receptor subunit alpha-1 (BMDBP01848)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01848 |
| Secondary Accession Numbers | None |
| Name | Glycine receptor subunit alpha-1 |
| Synonyms | Not Available |
| Gene Name | GLRA1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in chloride ion binding |
| Specific Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability (PubMed:11178872). Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | GLRA1 |
| Gene Sequence |
>1374 bp ATGTACAGCTTCAATACTCTTCGACTCTACCTTTGGGAGACCATTGTATTCTTCAGTCTT GCTGCTTCCAAGGAGGCTGAAGCTGCTCGGTCTGCTTCCAAGCCCATGTCACCGTCCGAT TTCCTGGATAAACTCATGGGGAGGACTTCTGGATACGACGCCAGGATCAGGCCCAATTTC AAAGGTCCCCCAGTGAATGTCAGCTGCAACATTTTCATCAACAGCTTCGGTTCCATTGCT GAGACAACTATGGACTACAGGGTCAACATCTTCCTGCGGCAGCAGTGGAATGACCCCCGG CTGGCCTACAATGAATACCCCGATGACTCGCTGGACTTGGACCCATCCATGTTGGACTCC ATCTGGAAACCTGACCTGTTCTTTGCCAATGAGAAGGGGGCCCACTTCCATGAGATCACC ACAGACAACAAACTGCTGAGGATCTCCCGGAACGGGAATGTCCTCTACAGCATTAGGATC ACCCTGACATTGGCCTGCCCCATGGACTTGAAGAATTTCCCCATGGATGTCCAGACGTGC ATTATGCAACTGGAAAGCTTTGGATACACCATGAACGACCTCATCTTTGAGTGGCAGGAG CAGGGGGCTGTGCAGGTGGCAGATGGACTAACTCTACCCCAGTTTATCCTGAAAGAGGAG AAGGACTTGAGATACTGCACCAAGCATTACAACACAGGCAAATTCACCTGCATCGAGGCC CGGTTCCACCTGGAGCGACAGATGGGCTACTACCTGATCCAGATGTACATCCCCAGCCTG CTCATTGTCATCCTCTCGTGGATCTCCTTCTGGATCAACATGGATGCTGCTCCCGCCCGT GTGGGCCTGGGCATCACCACTGTGCTCACCATGACCACCCAGAGCTCCGGCTCTCGAGCA TCCCTGCCCAAGGTATCGTATGTGAAGGCCATCGACATTTGGATGGCCGTGTGCCTGCTC TTTGTGTTCTCAGCCCTGCTTGAGTACGCCGCCGTCAACTTTGTGTCTCGGCAGCACAAA GAGCTGCTCCGATTCAGGAGGAAGCGAAGACATCACAAGAGCCCCATGTTGAATCTGTTC CAGGAGGATGAGGCTGGAGAGGGCCGCTTCAACTTCTCGGCCTACGGCATGGGCCCAGCC TGCCTTCAGGCCAAGGATGGCATCTCTGTCAAGGGCGCCAACAACAGCAACACGACCAAC CCTCCTCCGGCACCATCCAAGTCCCCGGAGGAGATGCGAAAACTCTTCATCCAGCGGGCC AAGAAGATCGACAAGATCTCCCGCATCGGCTTCCCCATGGCCTTCCTCATCTTCAACATG TTCTACTGGATCATCTACAAAATCGTCCGCAGGGAGGACGTCCACAACCAGTGA |
| Protein Properties | |
| Number of Residues | 457 |
| Molecular Weight | 52614.0 |
| Theoretical pI | 9.04 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Glycine receptor subunit alpha-1 MYSFNTLRLYLWETIVFFSLAASKEAEAARSASKPMSPSDFLDKLMGRTSGYDARIRPNF KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ |
| External Links | |
| GenBank ID Protein | AAG14346.1 |
| UniProtKB/Swiss-Prot ID | P57695 |
| UniProtKB/Swiss-Prot Entry Name | GLRA1_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF268375 |
| GeneCard ID | GLRA1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |