| Identification |
|---|
| BMDB Protein ID
| BMDBP01853 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-aminobutyric acid receptor subunit beta-1 |
| Synonyms
|
Not Available
|
| Gene Name
| GABRB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| GABRB1 |
| Gene Sequence
|
>1425 bp
ATGTGGACAGTACAAAATCGAGAGAGTTTGGGGCTTCTCTCTTTCCCTGTGATGATTGCC
ATGGTCTGTTGTGCACACAGCGCCAACGAGCCCAGCAACATGTCATACGTGAAAGAGACA
GTGGACAGATTGCTCAAAGGATATGACATTCGCTTGCGGCCGGACTTTGGAGGGCCCCCC
GTGGACGTCGGGATGAGGATCGATGTCGCCAGCATAGACATGGTCTCCGAAGTGAACATG
GATTATACTCTCACCATGTATTTCCAGCAGTCTTGGAAAGACAAAAGGCTTTCTTATTCT
GGAATCCCACTAAACCTCACACTAGACAACAGGGTGGCTGATCAACTCTGGGTACCAGAC
ACCTACTTTCTGAATGACAAGAAATCCTTTGTGCATGGGGTTACAGTGAAAAATCGCATG
ATCCGCCTGCATCCTGATGGAACAGTTCTCTACGGACTCCGGATCACAACCACAGCTGCG
TGCATGATGGATCTACGAAGATATCCTCTGGATGAACAAAACTGCACCCTGGAGATTGAA
AGTTATGGCTACACCACTGATGACATTGAGTTTTACTGGAATGGAGGAGAGGGCGCAGTA
ACAGGAGTGAATAAAATTGAGCTCCCTCAGTTTTCAATTGTTGATTACAAGATGGTGTCC
AAAAAGGTGGAATTCACAACAGGGGCATACCCACGACTGTCACTAAGTTTTCGTCTAAAA
AGAAACATCGGTTACTTCATTTTGCAAACCTACATGCCTTCCACACTGATTACAATTCTG
TCGTGGGTGTCGTTTTGGATCAATTATGACGCATCTGCAGCCAGAGTTGCACTAGGAATC
ACCACAGTGCTGACAATGACCACCATCAGCACTCACCTCAGGGAGACCCTGCCAAAGATT
CCTTATGTCAAAGCGATTGACATTTACCTGATGGGTTGCTTCGTGTTTGTGTTCCTGGCT
CTGCTGGAATATGCCTTTGTAAATTACATCTTTTTTGGAAAGGGCCCTCAGAAGAAAGGA
GCTGGCAAACAAGACCAGAGCGCTAATGAGAAGAACAAACTGGAGATGAATAAAGTCCAG
GTCGACGCCCACGGCAACATTCTCCTCAGTACCCTGGAGATCAGGAACGAGACGAGCGGC
TCTGAAGTGCTCACGGGCGTGGGAGACCCCAAGACCACCATGTACTCCTACGACAGCGCC
AGCATCCAGTACCGCAAGCCAATGAGCAGCCGCGAGGGGTACGGGCGCGCGCTGGACCGG
CACGGCGCGCACAGCAAGGGGCGCATCCGCAGACGCGCCTCGCAGCTCAAAGTCAAAATC
CCCGACTTGACTGACGTGAATTCCATAGACAAGTGGTCCCGAATGTTCTTCCCCATCACC
TTTTCTCTTTTTAACGTCGTTTATTGGCTTTACTATGTACACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 474 |
| Molecular Weight
| 54130.0 |
| Theoretical pI
| 9.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 246-267
- 271-293
- 305-327
- 452-473
|
| Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit beta-1
MWTVQNRESLGLLSFPVMIAMVCCAHSANEPSNMSYVKETVDRLLKGYDIRLRPDFGGPP
VDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPD
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLK
RNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKI
PYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGAGKQDQSANEKNKLEMNKVQ
VDAHGNILLSTLEIRNETSGSEVLTGVGDPKTTMYSYDSASIQYRKPMSSREGYGRALDR
HGAHSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
|
| External Links |
|---|
| GenBank ID Protein
| CAA29190.1 |
| UniProtKB/Swiss-Prot ID
| P08220 |
| UniProtKB/Swiss-Prot Entry Name
| GBRB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X05718 |
| GeneCard ID
| GABRB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
