| Identification |
|---|
| BMDB Protein ID
| BMDBP01855 |
| Secondary Accession Numbers
| None |
| Name
| H(+)/Cl(-) exchange transporter 7 |
| Synonyms
|
Not Available
|
| Gene Name
| CLCN7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Slowly voltage-gated channel mediating the exchange of chloride ions against protons (By similarity). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| CLCN7 |
| Gene Sequence
|
>2430 bp
ATGGCCAACGTTTCCAAGAAGGTGTCGTGGTCCGGCCGCGACCTGGACGACGACGAGGCG
GCGCCGCTGCTGCGGAGGGCGCCGCGGCTCGGGGTGCCGGCCGGCGAGGCGGCGCCGCTG
CTGAACGGGGCTGGGCCCGCGGCCGCCCGCGCGTCACCACACTCGGCATTCTTTCGGATC
GGACAGTTGAGCAGCGTGGAGCTGGATGATGAGCTTCTGGACCCTGACATGGACCCCCCT
CACCCCTTCCCCAGGGAGATCCCACACAACGAGAAGCTGCTGTCCCTCAAGTACGAGAGC
CTGGACTACGACAACAGTGAGAACCAGCTGTTCCTGGAGGAAGAGCGGCGTATCAACCAC
ACGGCTTTCCGGACGGTGGAGATCAAGCGCTGGGTCATCTGCGCCATGGTGGGCATCCTC
ACGGGTCTCGTGGCCTGCTTCATCGACATCGTGGTGGAGAAGCTGGCCGGCCTCAAGTAC
AGGCTCGTCAAGGACAACATCGACAGGTTCACCGAGCATGGCGGACTGTCCTTCTCCCTC
CTGCTCTGGGCCGCACTCAATGCCGCCTTCGTGCTCCTCGGCTCCACCATCGTCGCCTTC
ATAGAGCCGGTTGCTGCTGGCAGCGGGATCCCCCAGATCAAGTGCTTCCTCAATGGGGTG
AAGATCCCCCACGTGGTCAGGCTCAAGACCCTGGTGATCAAAGTGTCTGGCGTGATCCTG
TCAGTGGTGGGGGGACTGGCCGTGGGGAAGGAGGGGCCGATGATCCACTCGGGCTCGGTG
ATCGCCGCGGGCATCTCCCAGGGCAGGTCCACGTCGCTGAAGCGGGACTTCAAGATCTTC
GAGTACTTTCGCAGAGACACAGAGAAGCGGGACTTCGTCTCGGCAGGAGCTGCAGCTGGA
GTGTCCGCAGCCTTTGGGGCCCCTGTGGGTGGGGTGCTGTTCAGCTTGGAGGAGGGCGCG
TCCTTCTGGAACCAGTTCCTGACGTGGAGAATCTTCTTTGCTTCCATGATCTCCACTTTC
ACCTTGAACTTCGTCCTGAGTATTTACCATGGGAACGCGTGGGACCTGTCCAGCCCTGGG
CTCATCAACTTTGGAAGATTTGATACTGAGACCATGGTGTACGTGATCCACGAGATCCCC
ATCTTCATCGCCATGGGTGTTGTGGGGGGCATTCTCGGAGCTGTGTTCAACGCCTTGAAT
TACTGGCTGACGATGTTTCGAATCAGGTACGTCCACCGGCCCTGCCTCCAGGTGGTCGAG
GCCACGCTGGTCGCCGCCGTCACCGCCACGGCCGCCTTCGTGCTCATCTACTCATCCCGG
GACTGTCAGCCTCTGCGGGGGAGCTCCGTGTCCTACCCCCTCCAGCTCTTCTGTGCTGAT
GGGGAGTACAACTCGATGGCCGTGGCCTTCTTCAACACCCCGGAGAAGAGCGTGGTCAGC
CTTTTCCACGACCCCCCAGGCTCCTACAACCCCATGACGCTCGGCCTGTTTACCCTGGTC
TACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCAGCCGGCGTCTTCATTCCG
TCCCTCCTCATTGGGGCTGCCTGGGGCCGGCTGTTCGGCATCTCCCTGTCCTACATCACG
GGGGCTGCGGTCTGGGCGGACCCTGGCAAGTACGCCCTAATGGGAGCCGCTGCGCAGCTG
GGTGGGATCGTGAGGATGACGCTGAGCCTGACGGTCATCATGATGGAGGCCACCAGCAGT
GTGACCTACGGCTTCCCCATCATGCTGGTGCTCATGACCGCCAAGATCGTGGGGGACGTC
TTCATCGAGGGCCTGTATGACATGCACATCCAGCTGCAGAGCGTGCCCTTCTTGCACTGG
GAGGCCCCTGTCACCTCGCACTCACTCACCGCCAGGGAGGTGATGAGCACGCCGGTCACC
TGCCTGCGGAGGAGGGAGAAGGTGGGCGTCATCGTGGACGTGCTGAGCAGCACGGCGTCC
AATCACAACGGCTTCCCCGTGGTGGAGGATGCTGACGGCACGCAGCCAGCTCGGCTCCAG
GGCTTGATCCTGCGCTCTCAGCTCATCGTCCTACTCAAGCACAAGGTGTTCGTGGAGCGC
TCCAGCATGGGCCTGCTGCGACGCCGGCTGCGGCTGAAGGACTTCCGTGACGCCTACCCA
CGCTTCCCCCCAATCCAGTCCATCCACGTGTCACAGGATGAGCGGGAGTGCACCATGGAC
CTGTCTGAGTTCATGAACCCCTCGCCCTACACGGTGCCCCAGGAGGCGTCCCTCCCACGG
GTGTTCAAGCTGTTCCGGGCCCTGGGCCTCCGGCACCTGGTGGTGGTGGACAATTGCAAT
CAGGTGGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCGGCTTGGAAAGGGGGGC
CTGGAGGAGCTCTCTCTGGCCCAGACGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 809 |
| Molecular Weight
| 88831.0 |
| Theoretical pI
| 7.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 131-163
- 178-201
- 227-245
- 251-268
- 326-345
- 379-409
- 414-436
- 491-511
- 516-539
- 583-601
|
| Protein Sequence
|
>Chloride channel protein 7
MANVSKKVSWSGRDLDDDEAAPLLRRAPRLGVPAGEAAPLLNGAGPAAARASPHSAFFRI
GQLSSVELDDELLDPDMDPPHPFPREIPHNEKLLSLKYESLDYDNSENQLFLEEERRINH
TAFRTVEIKRWVICAMVGILTGLVACFIDIVVEKLAGLKYRLVKDNIDRFTEHGGLSFSL
LLWAALNAAFVLLGSTIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVIL
SVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAG
VSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNAWDLSSPG
LINFGRFDTETMVYVIHEIPIFIAMGVVGGILGAVFNALNYWLTMFRIRYVHRPCLQVVE
ATLVAAVTATAAFVLIYSSRDCQPLRGSSVSYPLQLFCADGEYNSMAVAFFNTPEKSVVS
LFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYIT
GAAVWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSSVTYGFPIMLVLMTAKIVGDV
FIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSSTAS
NHNGFPVVEDADGTQPARLQGLILRSQLIVLLKHKVFVERSSMGLLRRRLRLKDFRDAYP
RFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNCN
QVVGLVTRKDLARYRLGKGGLEELSLAQT
|
| External Links |
|---|
| GenBank ID Protein
| AAY82470.1 |
| UniProtKB/Swiss-Prot ID
| Q4PKH3 |
| UniProtKB/Swiss-Prot Entry Name
| CLCN7_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ073465 |
| GeneCard ID
| CLCN7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
