| Identification |
|---|
| BMDB Protein ID
| BMDBP01856 |
| Secondary Accession Numbers
| None |
| Name
| Chloride intracellular channel protein 5 |
| Synonyms
|
Not Available
|
| Gene Name
| CLIC5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride ion binding |
| Specific Function
| Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| CLIC5 |
| Gene Sequence
|
>1314 bp
ATGAATGACGAAAACTACAGCACCACCATCTACAACAGAGTCCAAACAGAGAGGGTGTAT
GAGGATTCAGACCCAGCAGAAAACGGAGGTCCCCTTTACGATGAAGTCCATGAAGATGTG
AGGAGGGAAGACAACTTATATGTCAATGAGCTGGAAAACCAAGAATATGACTCTGTGGCC
GTGTACCCTGTTGGGCGTCAGGGGAGAACCTCGGCCTCTTTACAGCCAGAAACAGGAGAA
TACGTCCTGCCTGATGAACCATATTCTAAGGCTCAGGACCCCCACCCAGGGGAACCCACA
GCGGACGAGGACATCTCCTTGGAAGAATTGCTCTCACCAACCAAGGACCACCAGTCTGAC
TCAGAGGAGCCCCAGGCGTCTGACCCAGAGGAGCCCCAGGCGTCTGACCCAGAGGAGCCC
CAGGGGCCTGACCCAGAGGAGCCCCAGGAGAATGGAAACGAGATGGAGGCAGACCTGCCT
TCTCCTTCGAGCTTCACCATCCAGAATAGCAGAGCCTTCTCCACCCGCGAGATCTCCCCT
ACCAGCTATTCTGCTGACGATGTTTCAGAAGGAAACGAATCGGCTTCCGCAAGCCCCGAG
ATTAACCTCTTTGTGAAGGCTGGAATCGATGGTGAAAGCATTGGCAACTGTCCCTTCTCT
CAGCGTCTCTTTATGATCCTCTGGCTGAAAGGAGTTGTGTTCAATGTCACCACGGTGGAT
CTGAAAAGAAAGCCAGCTGACCTGCACAACCTTGCCCCTGGCACTCATCCACCCTTCCTG
ACGTTCAACGGGGATGTGAAGACAGACGTCAATAAGATCGAGGAGTTCCTGGAGGAGACT
TTGACCCCTGAAAAGTACCCCAGACTGGCTGCGAAACATCGGGAATCCAACACGGCAGGC
ATCGACATCTTCGTTAAGTTCTCCGCCTACATCAAAAACACGAAGCAGCAGAGCAACGCT
GCCCTTGAGCGAGGCCTGACCAAGGCTCTGAAGAAGCTGGATGACTACCTGAACACCCCT
CTGCCGGAGGAGATCGATGCCGACACTCGCGGGGATGATGAAAAGGGCTCCCGGCGCAAG
TTCCTGGATGGGGACGAGTTGACCCTGGCCGACTGCAACCTGTTGCCCAAGCTCCATGTG
GTCAAGATTGTGGCCAAGAAATACCGCAACTACGATTTCCCGGCTGAGATGACGGGTCTG
TGGCGGTACCTCAAGAACGCCTACGCCCGGGACGAGTTCACCAACACCTGCGCGGCCGAC
AGCGAGATCGAGCTGGCCTATGCGGACGTGGCCAAGCGCCTCAGCCGATCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 437 |
| Molecular Weight
| 48959.0 |
| Theoretical pI
| 4.2 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Chloride intracellular channel protein 5
MNDENYSTTIYNRVQTERVYEDSDPAENGGPLYDEVHEDVRREDNLYVNELENQEYDSVA
VYPVGRQGRTSASLQPETGEYVLPDEPYSKAQDPHPGEPTADEDISLEELLSPTKDHQSD
SEEPQASDPEEPQASDPEEPQGPDPEEPQENGNEMEADLPSPSSFTIQNSRAFSTREISP
TSYSADDVSEGNESASASPEINLFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVD
LKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPRLAAKHRESNTAG
IDIFVKFSAYIKNTKQQSNAALERGLTKALKKLDDYLNTPLPEEIDADTRGDDEKGSRRK
FLDGDELTLADCNLLPKLHVVKIVAKKYRNYDFPAEMTGLWRYLKNAYARDEFTNTCAAD
SEIELAYADVAKRLSRS
|
| External Links |
|---|
| GenBank ID Protein
| AAA02561.1 |
| UniProtKB/Swiss-Prot ID
| P35526 |
| UniProtKB/Swiss-Prot Entry Name
| CLIC5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L16547 |
| GeneCard ID
| CLIC5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
