Showing Protein Gamma-aminobutyric acid receptor subunit gamma-2 (BMDBP01858)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01858 |
| Secondary Accession Numbers | None |
| Name | Gamma-aminobutyric acid receptor subunit gamma-2 |
| Synonyms | Not Available |
| Gene Name | GABRG2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in chloride channel activity |
| Specific Function | Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (By similarity). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor, alpha2/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | GABRG2 |
| Gene Sequence | Not Available |
| Protein Properties | |
| Number of Residues | 475 |
| Molecular Weight | 55265.0 |
| Theoretical pI | 8.94 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Gamma-aminobutyric acid receptor subunit gamma-2 MSSPNIWSTGSSVYSTPVFSQKMTLWILLLLSLYPGLTRQKSDDDYEDYASNKTWVLTPK VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFGQT WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVSDTRSWRLYQF SFVGLRNTTEVVKTTSGDYVVMTVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV SNRKPSKDKDKKKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGK DCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL |
| External Links | |
| GenBank ID Protein | AAA30531.1 |
| UniProtKB/Swiss-Prot ID | P22300 |
| UniProtKB/Swiss-Prot Entry Name | GBRG2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | M55563 |
| GeneCard ID | GABRG2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |