Showing Protein Glycine receptor subunit beta (BMDBP01867)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01867 |
| Secondary Accession Numbers | None |
| Name | Glycine receptor subunit beta |
| Synonyms | Not Available |
| Gene Name | GLRB |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in chloride ion binding |
| Specific Function | Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 17 |
| Locus | Not Available |
| SNPs | GLRB |
| Gene Sequence |
>1494 bp ATGAAGTTTTTATTGGCAGTGGCCTTTTTTATTTTAATTTCCTTGTGTATTGAAGAAGCC TACTCAAAAGAAAAGTCTTCAAAGAAAGGGAAGGGGAAAAAGAAGCAGTACCTATGTCCA TCGCAACAGTCAGCAGAGGATCTAGCCCGAGTACCCGCCAACTCCACCAGCAATATCTTG AACAGGCTGCTGGTCAGTTACGATCCCAGGATAAGACCAAATTTCAAAGGCATTCCTGTT GATGTAGTAGTCAACATTTTTATCAACAGTTTTGGATCTATTCAAGAGACAACAATGGAT TATAGAGTCAACATCTTCCTGAGGCAAAAATGGAACGATCCCAGGTTGAAGCTCCCTAGT GATTTCCGGGGCTCGGATGCCCTGACCGTGGACCCCACAATGTACAAATGTCTGTGGAAA CCTGATTTATTTTTTGCAAATGAAAAAAGTGCCAATTTTCATGATGTCACCCAGGAAAAC ATCCTTCTCTTCATTTTTCGAGATGGAGATGTCCTTGTCAGTATGAGGTTATCTATTACT CTTTCCTGCCCTTTGGACTTGACCTTGTTTCCCATGGATACACAGCGTTGCAAGATGCAA CTTGAGAGCTTTGGTTACACGACTGATGACTTAAGATTTATCTGGCAGTCGGGGGATCCT GTCCAGTTAGAAAAAATTGCCTTGCCTCAATTTGATATTAAAAAAGAAGATATTGAATAT GGTAACTGCACAAAATACTATAAAGGCACTGGGTACTACACGTGTGTGGAAGTCATCTTC ACCCTGAGGAGGCAGGTGGGCTTCTACATGATGGGCGTCTATGCCCCGACCCTGCTCATC GTGGTTCTGTCCTGGCTTTCCTTCTGGATCAACCCTGATGCCAGTGCTGCCAGAGTGCCC CTGGGAATCTTCTCAGTACTGAGTTTGGCCTCTGAGTGTACAACCCTGGCTGCAGAACTT CCCAAGGTGTCTTATGTGAAGGCGCTGGACGTGTGGCTCATCGCATGTCTCCTCTTTGGC TTTGCGTCCCTGGTGGAGTACGCAGTCGTCCAGGTGATGCTCAATAACCCCAAGCGAGTT GAAGCAGAAAAAGCCAGAATTGCCAAGGCTGAGCAAGCAGTTGGGAAGGGGGGAAATGTG GCTAAAAAGAACACTGTGAATGGCGCAAGCACACCTGTTCACATCAGCACCTTGCAGGTT GGGGAGACTAGATGCAAAAAGGTTTGTACGTCCAAGTCTGATCTGAGATCTAACGACTTC AGCATTGTGGGAAGCTTACCGAGAGATTTTGAATTGTCCAATTATGACTGCTATGGAAAA CCCATTGAGGTCAACAACGGACTTGGGAAGTCTCAGGCCAAGAACAACAAGAAACCACCT CCTGCCAAACCCGTTATTCCGACAGCAGCAAAGAGAATCGACCTTTACGCGAGAGCCTTG TTTCCTTTCTGCTTCTTATTCTTCAATGTTATCTACTGGTCTATATATTTATGA |
| Protein Properties | |
| Number of Residues | 497 |
| Molecular Weight | 56039.0 |
| Theoretical pI | 9.12 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Glycine receptor subunit beta MKFLLAVAFFILISLCIEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNIL NRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPS DFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEY GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRV EAEKARIAKAEQAVGKGGNVAKKNTVNGASTPVHISTLQVGETRCKKVCTSKSDLRSNDF SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARAL FPFCFLFFNVIYWSIYL |
| External Links | |
| GenBank ID Protein | AAG14347.1 |
| UniProtKB/Swiss-Prot ID | Q9GJS9 |
| UniProtKB/Swiss-Prot Entry Name | GLRB_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AF268376 |
| GeneCard ID | GLRB |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |