| Identification |
|---|
| BMDB Protein ID
| BMDBP01867 |
| Secondary Accession Numbers
| None |
| Name
| Glycine receptor subunit beta |
| Synonyms
|
Not Available
|
| Gene Name
| GLRB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride ion binding |
| Specific Function
| Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| GLRB |
| Gene Sequence
|
>1494 bp
ATGAAGTTTTTATTGGCAGTGGCCTTTTTTATTTTAATTTCCTTGTGTATTGAAGAAGCC
TACTCAAAAGAAAAGTCTTCAAAGAAAGGGAAGGGGAAAAAGAAGCAGTACCTATGTCCA
TCGCAACAGTCAGCAGAGGATCTAGCCCGAGTACCCGCCAACTCCACCAGCAATATCTTG
AACAGGCTGCTGGTCAGTTACGATCCCAGGATAAGACCAAATTTCAAAGGCATTCCTGTT
GATGTAGTAGTCAACATTTTTATCAACAGTTTTGGATCTATTCAAGAGACAACAATGGAT
TATAGAGTCAACATCTTCCTGAGGCAAAAATGGAACGATCCCAGGTTGAAGCTCCCTAGT
GATTTCCGGGGCTCGGATGCCCTGACCGTGGACCCCACAATGTACAAATGTCTGTGGAAA
CCTGATTTATTTTTTGCAAATGAAAAAAGTGCCAATTTTCATGATGTCACCCAGGAAAAC
ATCCTTCTCTTCATTTTTCGAGATGGAGATGTCCTTGTCAGTATGAGGTTATCTATTACT
CTTTCCTGCCCTTTGGACTTGACCTTGTTTCCCATGGATACACAGCGTTGCAAGATGCAA
CTTGAGAGCTTTGGTTACACGACTGATGACTTAAGATTTATCTGGCAGTCGGGGGATCCT
GTCCAGTTAGAAAAAATTGCCTTGCCTCAATTTGATATTAAAAAAGAAGATATTGAATAT
GGTAACTGCACAAAATACTATAAAGGCACTGGGTACTACACGTGTGTGGAAGTCATCTTC
ACCCTGAGGAGGCAGGTGGGCTTCTACATGATGGGCGTCTATGCCCCGACCCTGCTCATC
GTGGTTCTGTCCTGGCTTTCCTTCTGGATCAACCCTGATGCCAGTGCTGCCAGAGTGCCC
CTGGGAATCTTCTCAGTACTGAGTTTGGCCTCTGAGTGTACAACCCTGGCTGCAGAACTT
CCCAAGGTGTCTTATGTGAAGGCGCTGGACGTGTGGCTCATCGCATGTCTCCTCTTTGGC
TTTGCGTCCCTGGTGGAGTACGCAGTCGTCCAGGTGATGCTCAATAACCCCAAGCGAGTT
GAAGCAGAAAAAGCCAGAATTGCCAAGGCTGAGCAAGCAGTTGGGAAGGGGGGAAATGTG
GCTAAAAAGAACACTGTGAATGGCGCAAGCACACCTGTTCACATCAGCACCTTGCAGGTT
GGGGAGACTAGATGCAAAAAGGTTTGTACGTCCAAGTCTGATCTGAGATCTAACGACTTC
AGCATTGTGGGAAGCTTACCGAGAGATTTTGAATTGTCCAATTATGACTGCTATGGAAAA
CCCATTGAGGTCAACAACGGACTTGGGAAGTCTCAGGCCAAGAACAACAAGAAACCACCT
CCTGCCAAACCCGTTATTCCGACAGCAGCAAAGAGAATCGACCTTTACGCGAGAGCCTTG
TTTCCTTTCTGCTTCTTATTCTTCAATGTTATCTACTGGTCTATATATTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 497 |
| Molecular Weight
| 56039.0 |
| Theoretical pI
| 9.12 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 269-290
- 296-316
- 328-348
- 476-496
|
| Protein Sequence
|
>Glycine receptor subunit beta
MKFLLAVAFFILISLCIEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNIL
NRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPS
DFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSIT
LSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEY
GNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVP
LGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRV
EAEKARIAKAEQAVGKGGNVAKKNTVNGASTPVHISTLQVGETRCKKVCTSKSDLRSNDF
SIVGSLPRDFELSNYDCYGKPIEVNNGLGKSQAKNNKKPPPAKPVIPTAAKRIDLYARAL
FPFCFLFFNVIYWSIYL
|
| External Links |
|---|
| GenBank ID Protein
| AAG14347.1 |
| UniProtKB/Swiss-Prot ID
| Q9GJS9 |
| UniProtKB/Swiss-Prot Entry Name
| GLRB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF268376 |
| GeneCard ID
| GLRB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
