| Identification |
|---|
| BMDB Protein ID
| BMDBP01871 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-aminobutyric acid receptor subunit alpha-1 |
| Synonyms
|
Not Available
|
| Gene Name
| GABRA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:3037384). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (By similarity). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (By similarity). GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| GABRA1 |
| Gene Sequence
|
>1371 bp
ATGAAGAAAAGTCCGGGTCTCTCTGACTACCTTTGGGCCTGGACCCTCTTTCTGAGCACA
TTGACTGGAAGAAGCTATGGACAACCCTCATTACAAGATGAACTTAAAGACAACACCACT
GTCTTCACCAGGATTTTGGACCGACTCCTAGATGGTTATGACAATCGCCTGAGACCGGGA
TTAGGAGAGCGTGTAACTGAAGTGAAGACTGACATCTTCGTCACCAGTTTCGGACCCGTT
TCAGACCATGATATGGAATATACAATAGATGTATTTTTCCGTCAAAGCTGGAAGGATGAA
AGGTTAAAATTTAAAGGACCTATGACAGTACTCCGATTAAATAACCTAATGGCAAGTAAA
ATCTGGACTCCGGATACCTTTTTCCACAATGGAAAGAAGTCAGTGGCACACAACATGACC
ATGCCGAACAAGCTCCTGCGCATCACAGAGGACGGCACTTTGCTGTACACCATGAGACTG
ACGGTGAGAGCCGAATGTCCAATGCATTTGGAGGATTTCCCTATGGATGCCCATGCCTGC
CCTCTAAAATTTGGAAGCTATGCTTATACAAGAGCAGAAGTTGTTTATGAGTGGACCAGA
GAGCCAGCACGCTCAGTGGTTGTAGCCGAAGATGGGTCACGCCTGAACCAGTACGATCTT
CTTGGACAAACAGTAGATTCTGGAATTGTTCAGTCTAGTACAGGAGAGTATGTTGTTATG
ACAACTCATTTCCACCTGAAGAGAAAGATTGGATATTTTGTTATTCAAACATACCTGCCG
TGCATAATGACAGTTATTCTCTCCCAAGTCTCATTCTGGCTCAACAGAGAGTCTGTGCCA
GCGAGGACGGTCTTTGGAGTCACAACTGTGCTCACCATGACAACTTTGAGTATCAGTGCC
AGAAATTCCCTCCCTAAGGTGGCTTATGCAACTGCTATGGATTGGTTTATTGCAGTGTGC
TATGCCTTTGTATTCTCAGCTCTGATCGAGTTTGCCACAGTAAACTATTTCACCAAGAGA
GGTTATGCATGGGATGGGAAAAGTGTGGTTCCAGAAAAGCCAAAGAAAGTGAAGGACCCT
CTTATTAAGAAAAACAACACTTATGCTCCAACAGCAACCAGCTACACACCTAATCTGGCC
AGGGGTGACCCCGGCTTAGCCACCATTGCTAAAAGTGCAACCATAGAACCAAAAGAAGTC
AAGCCGGAAACAAAACCACCAGAACCGAAGAAAACCTTTAACAGTGTCAGCAAAATTGAC
CGACTGTCAAGAATAGCCTTCCCGCTGTTATTCGGAATCTTTAACTTGGTCTATTGGGCA
ACATATTTAAACAGAGAGCCTCAGCTAAAAGCCCCCACCCCCCATCAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 456 |
| Molecular Weight
| 51856.0 |
| Theoretical pI
| 9.65 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 252-273
- 279-300
- 313-334
- 422-443
|
| Protein Sequence
|
>Gamma-aminobutyric acid receptor subunit alpha-1
MKKSPGLSDYLWAWTLFLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
|
| External Links |
|---|
| GenBank ID Protein
| CAA29189.1 |
| UniProtKB/Swiss-Prot ID
| P08219 |
| UniProtKB/Swiss-Prot Entry Name
| GBRA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X05717 |
| GeneCard ID
| GABRA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
