Showing Protein Sodium/myo-inositol cotransporter 2 (BMDBP01874)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01874 |
| Secondary Accession Numbers | None |
| Name | Sodium/myo-inositol cotransporter 2 |
| Synonyms | Not Available |
| Gene Name | SLC5A11 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in sodium ion binding |
| Specific Function | Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney. |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 25 |
| Locus | Not Available |
| SNPs | SLC5A11 |
| Gene Sequence |
>2025 bp ATGGAGAGCAGCGCCAGCAGCCCTCCTCTCACACAGTCAGATCCCCTGGAGGCGTTTCCC CGGAGGACGCTGGAAGCAGGAGACATCGCAGTGCTGGTTCTATATTTCCTCTTTGTCCTG GCTGTTGGACTATGGTCCACAGTGAAGACCAAAAGAGACACCGTGAAAGGCTACTTTCTA GCTGGAGGCAACATGCTGTGGTGGCCAGTGGGTGCATCCTTGTTTGCCAGCAACGTTGGA AGTGGACATTTCGTTGGCCTGGCAGGGTCAGGTGCTGCTGCGGGTCTTTCTGTAACTGCT TATGAGCTTAATGGCTTATTTTTCGTGCTGATGTTGTCCTGGATCTTCCTTCCAATCTAC ATCACTGGTCAGGTCACCACGATGCCAGAGTACCTACGGAAACGTTTTGGTGGCAACAGG ATTCCCATCATCCTGGCTGTGCTCTACCTGTTTATCTACATCTTCACCAAGATCTCGGTG GACATGTATGCAGGCGCCATCTTCATTCAGCAGTCTTTGCATGTGAATCTCTACTTGGCC ATAGTCGGGTTGCTGGCCGTCACAGCTCTATACACCATCGCAGGTGGCCTGGCAGCTGTG ATCTACACGGATGCTCTACAGACTCTGATCATGCTTATAGGAGCGCTCATCCTGATGGGC TACAGTTTTGCTGCAGTTGGTGGGTTGGAAGGCTTGGAGGAGAAATATTTTTTGGCAATG GCCAGCAACCGGAGCGGGAACAGCAGCTGCGGGTTGCCCCGGGAAGATGCCTTCCATATT TTCCGAGACCCAGTGACGTCTGATCTCCCATGGCCCGGGATCCTATTTGGAATGTCCATC CCGTCTCTCTGGTATTGGTGCACGGATCAGGTGATTGTTCAGCGGACTCTGGCTGCCAAG AACCTGTCCCACGCCAAAGGGGGCTCTCTGATGGCCGCATACCTGAAGGTGCTACCCCTT TTCATCATGGTGTTCCCGGGTATGGTCAGCCGTGTCCTCTTTCCAGACGAAGTAGCTTGT GCAGACCCAGAAATCTGCCGGAAGGTCTGTAGCAACCCCGCCGGCTGCTCTGACATCGCG TATCCCAAACTTGTGCTGGAACTCCTGCCTACAGGGCTCCGTGGGCTCATGATGGCTGTG ATGGTGGCGGCGCTCACGTCTTCCCTCACCTCCATCTTTAACAGTGCCAGCACCATCTTC ACCATGGACCTCTGGAACCATCTCCGGCCTCGGGCATCTGAGAAGGAGCTCATGATTGTG GGCAGGGTGTTTGTGTTGCTTCTGGTGTTGGTCTCCATCCTCTGGATCCCTGTGGTCCAG GCCAGCCAGGGCGGCCAGCTCTTCATCTACATCCAGTCCATCAGCTCCTACCTACAGCCA CCTGTGGCTGTGGTCTTCATCATGGGATGTTTCTGGAAGCGGGCCAATGAAAAGGGTGCC TTCTTCGGTCTCGTCTTAGGCCTCCTCCTAGGCTTGGTTAGGCTGATCCTGGACTTCATT TACGTGCAGCCTCGCTGTGACCAGCTGGATGAGCGCCCAGCCGTGGTAAAGGATGTCCAC TACCTCTACTTCTCTATGATCCTGTCCTCGGTCACCCTGATCACAGTGTGTGCCGTGAGC TGGTTCACAGAGCCGCCCTCCAAGGAAATGGTCAGTCGCTTGACCTGGTTTACTCGCCAT GACCCCGTGGTCCAGAAGGAACAGGTGCCGTCAGCAACCCCACCGCCTCTTACCCTTTCT CAAAACGGGACACCAGAGGCCAGCGGCACCAACACCCAGTTCGAGATGGTTCAAGAAAAC CTGTCCAAAACCCACAGCTGCGACATGACCACAAAGCGGTCCAAAGTGGTGAAAGCCATC TTGTGGCTCTGTGGGGTGGAGAACAAGGGCAAGGAGCAAGCACCCAGCAGAGCGGACCCG ATCATAGTTTCCCTGGAAGAAAACCCCTTGGTGAAAACCCTTCTGGACCTCAACCTCATC ATTTGCATCAGCTGTGCCATATTTCTCTGGGGCTACTTTGCTTAA |
| Protein Properties | |
| Number of Residues | 674 |
| Molecular Weight | 73957.0 |
| Theoretical pI | 7.59 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
|
| Protein Sequence |
>Sodium/myo-inositol cotransporter 2 MESSASSPPLTQSDPLEAFPRRTLEAGDIAVLVLYFLFVLAVGLWSTVKTKRDTVKGYFL AGGNMLWWPVGASLFASNVGSGHFVGLAGSGAAAGLSVTAYELNGLFFVLMLSWIFLPIY ITGQVTTMPEYLRKRFGGNRIPIILAVLYLFIYIFTKISVDMYAGAIFIQQSLHVNLYLA IVGLLAVTALYTIAGGLAAVIYTDALQTLIMLIGALILMGYSFAAVGGLEGLEEKYFLAM ASNRSGNSSCGLPREDAFHIFRDPVTSDLPWPGILFGMSIPSLWYWCTDQVIVQRTLAAK NLSHAKGGSLMAAYLKVLPLFIMVFPGMVSRVLFPDEVACADPEICRKVCSNPAGCSDIA YPKLVLELLPTGLRGLMMAVMVAALTSSLTSIFNSASTIFTMDLWNHLRPRASEKELMIV GRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRANEKGA FFGLVLGLLLGLVRLILDFIYVQPRCDQLDERPAVVKDVHYLYFSMILSSVTLITVCAVS WFTEPPSKEMVSRLTWFTRHDPVVQKEQVPSATPPPLTLSQNGTPEASGTNTQFEMVQEN LSKTHSCDMTTKRSKVVKAILWLCGVENKGKEQAPSRADPIIVSLEENPLVKTLLDLNLI ICISCAIFLWGYFA |
| External Links | |
| GenBank ID Protein | AAI02963.1 |
| UniProtKB/Swiss-Prot ID | Q3ZC26 |
| UniProtKB/Swiss-Prot Entry Name | SC5AB_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC102962 |
| GeneCard ID | SLC5A11 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |