| Identification |
|---|
| BMDB Protein ID
| BMDBP01877 |
| Secondary Accession Numbers
| None |
| Name
| Polycomb group RING finger protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| PCGF1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| PCGF1 |
| Gene Sequence
|
>744 bp
ATGAGGCTTCGGAACCAGCTCCAGTCAGTGTACAAGATGGACCCACTACGGAACGAGGAG
GAAGTACGAGTAAAGATCAAAGACTTGAACGAGCACATCGTCTGCTGCCTGTGCGCTGGC
TACTTCGTAGATGCCACCACCATAACAGAGTGTCTTCATACGTTCTGCAAGAGTTGTATT
GTGAAGTACCTCCAAACCAGCAAGTACTGCCCCATGTGTAACATCAAGATCCATGAAACA
CAACCACTGCTCAACCACAAACTGGACCGGGTCATGCAGGACATCGTGTACAAACTAGTG
CCAGGCTTGCAAGACAGTGAAGAGAAACGCATCCGAGAATTCTACCAGTCCCGAGGCTTG
GACCGGGTCACCCAGCCCAGTGGGGAAGAGCCAGCCCTGAGCAACCTTGGCCTCCCCTTC
AGCAGCTTCGACCACTCAAAAGCCCACTACTATCGCTATGATGAGCAGCTGAGCCTATGC
CTGGAGCGGCTGAGTTCTGGCAAAGACAAGAATAAAAGCATACTGCAGAACAAATATGTC
CGGTGTTCTGTTAGAGCTGAAGTTCGTCATCTCCGGAGGGTCCTGTGTCATCGCTTGATG
CTAAATCCCCAGCATGTGCAGCTCCTTTTTGACAATGAAGTTCTCCCTGATCACATGACC
ATGAAGCAGATATGGCTGTCCCACTGGTTCGGCAAACCATCCCCTTTGCTTTTACAATAC
AGCGTGAAAGAGAAGAGGAGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 259 |
| Molecular Weight
| 30324.0 |
| Theoretical pI
| 8.98 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 34-59
- 71-96
- 107-129
- 150-173
- 193-217
- 377-401
- 412-432
|
| Protein Sequence
|
>Polycomb group RING finger protein 1
MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTI
TECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNHKLDRVMQDIVYKLVPGLQDSEE
KRIREFYQSRGLDRVTQPSGEEPALSNLGLPFSSFDHSKAHYYRYDEQLSLCLERLSSGK
DKNKSILQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSH
WFGKPSPLLLQYSVKEKRR
|
| External Links |
|---|
| GenBank ID Protein
| AAI10243.1 |
| UniProtKB/Swiss-Prot ID
| Q2YDF9 |
| UniProtKB/Swiss-Prot Entry Name
| PCGF1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC110242 |
| GeneCard ID
| PCGF1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
