| Identification |
|---|
| BMDB Protein ID
| BMDBP01880 |
| Secondary Accession Numbers
| None |
| Name
| Retinoic acid receptor responder protein 2 |
| Synonyms
|
Not Available
|
| Gene Name
| RARRES2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Exhibits an antimicrobial function in the skin (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| RARRES2 |
| Gene Sequence
|
>489 bp
ATGTGGCAGCTACTGCTCCCCCTGGCCCTGGGGCTGGGCACCATGGGCTTGGGCAGGGCG
GAGCTCACGACGGCCCAGCACCGGGGCCTGCAGGTGGCCCTGGAGGAGTTCCACAAGCAT
CCACCCGTGCTGTGGGCCTTCCAGGTGACCAGCGTGGACAATGCGGCAGACACGCTCTTC
CCGGCTGGGCAGTTTGTGAGGCTGGAGTTCAAGCTCCAGCAGACGAGCTGTCGGAAGAAA
GACTGGAGGAAAGAAGACTGCAAAGTCAAGCCCAACGGGAGAAAGCGGAAATGCCTGGCC
TGCATCAAGCTGGACTCAAAAGATCAAGTCCTGGGCCGGATGGTGCACTGTCCCATACAG
ACTCAGGTTCAACGGGAGCTGGACGACGCCCAGGACGCCCAGTGCAGCAGGGTGGAGCGC
GCCGGCGAGGACCCCCACAGCTACTACCTCCCCGGACAGTTTGCCTTCATCAAAGCCTTG
TCCCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 162 |
| Molecular Weight
| 18357.0 |
| Theoretical pI
| 8.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 68-91
- 105-125
- 143-164
- 185-207
- 230-252
- 493-513
- 528-547
|
| Protein Sequence
|
>Retinoic acid receptor responder protein 2
MWQLLLPLALGLGTMGLGRAELTTAQHRGLQVALEEFHKHPPVLWAFQVTSVDNAADTLF
PAGQFVRLEFKLQQTSCRKKDWRKEDCKVKPNGRKRKCLACIKLDSKDQVLGRMVHCPIQ
TQVQRELDDAQDAQCSRVERAGEDPHSYYLPGQFAFIKALSP
|
| External Links |
|---|
| GenBank ID Protein
| AAI14048.1 |
| UniProtKB/Swiss-Prot ID
| Q29RS5 |
| UniProtKB/Swiss-Prot Entry Name
| RARR2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114047 |
| GeneCard ID
| RARRES2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
