Showing Protein Peroxisome proliferator-activated receptor gamma (BMDBP01883)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01883 |
| Secondary Accession Numbers | None |
| Name | Peroxisome proliferator-activated receptor gamma |
| Synonyms | Not Available |
| Gene Name | PPARG |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in protein binding |
| Specific Function | Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 22 |
| Locus | 22q24 |
| SNPs | PPARG |
| Gene Sequence |
>1518 bp ATGGGTGAAACTCTGGGAGATGCTCTTATTGACCCAGAGAGTGAGCCCTTCGCTGTCACA GTGTCTGCAAGGACCTCACAAGAAATTACCATGGTTGACACAGAGATGCCGTTTTGGCCC ACCAACTTTGGGATCAGCTCCGTGGACCTTTCTATGATGGATGACCACTCCCATGCCTTT GACATCAAGCCCTTCACCACCGTTGACTTCTCCAGCATTTCCACTCCGCACTATGAGGAC ATTCCGTTCCCAAGAGCTGACCCGATGGTTGCAGATTATAAGTATGACCTGAAGCTCCAA GAGTACCAAAGTGCAATCAAAGTGGAGCCTGTATCCCCACCTTATTATTCTGAAAAGACT CAGCTGTACAGTAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCCATTGAATGCCGG GTCTGTGGGGATAAAGCGTCAGGGTTCCACTATGGAGTTCATGCTTGTGAAGGATGCAAG GGTTTCTTCCGGAGGACAATCAGATTGAAACTTATTTACGATAGGTGTGATCTTAACTGT CGGATCCACAAGAAAAGTAGAAATAAATGTCAGTACTGTCGGTTTCAGAAGTGCCTTGCT GTGGGGATGTCTCATAATGCCATCAGGTTTGGGCGCATGCCACAGGCCGAGAAGGAGAAG CTGTTAGCGGAGATCTCCAGCGATATCGACCAACTGAACCCAGAGTCTGCTGACCTCCGG GCCCTGGCAAAGCATTTGTATGACTCGTACATAAAGTCCTTCCCGCTGACCAAAGCAAAG GCGAGGGCGATCTTGACGGGAAAGACGACAGACAAATCACCGTTTGTTATCTATGACATG AACTCCTTAATGATGGGAGAAGATAAAATCAAGTTCAAGCACATCAGTCCCCTGCAGGAG CCCAGCAAAGAGGTGGCCATCCGCATCTTCCAGGGGTGTCAGTTTCGCTCCGTGGAAGCC GTGCAGGAGATCACAGAGTACGCCAAGAATATCCCCGGCTTTGTGAACCTTGACTTGAAC GACCAAGTAACTCTCCTAAAATACGGCGTGCACGAGATCATTTACACGATGCTGGCCTCC TTGATGAATAAGGATGGGGTCCTCATATCCGAGGGCCAAGGATTCATGACAAGGGAGTTT CTAAAGAGCCTGCGAAAGCCCTTTGGTGACTTTATGGAGCCCAAGTTCGAGTTTGCTGTG AAGTTCAACGCACTGGAATTAGATGACAGCGACTTAGCAATATTTATAGCTGTCATTATT CTCAGTGGAGACCGCCCAGGTTTGCTGAACGTGAAGCCCATTGAGGACATACAAGACAAT CTGCTGCAAGCCTTGGAGCTGCAGCTCAAGCTGAACCACCCCGAGTCCTCCCAGCTCTTT GCCAAGCTGCTCCAGAAAATGACAGACCTCAGACAGATTGTGACAGAACACGTGCAGCTG TTGCAAGTAATAAAGAAAACAGAGACGGACATGAGTCTCCACCCACTCCTACAGGAAATC TACAAGGACTTGTATTAG |
| Protein Properties | |
| Number of Residues | 505 |
| Molecular Weight | 57579.0 |
| Theoretical pI | 6.04 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
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| Protein Sequence |
>Peroxisome proliferator-activated receptor gamma MGETLGDALIDPESEPFAVTVSARTSQEITMVDTEMPFWPTNFGISSVDLSMMDDHSHAF DIKPFTTVDFSSISTPHYEDIPFPRADPMVADYKYDLKLQEYQSAIKVEPVSPPYYSEKT QLYSKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHISPLQE PSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL LQVIKKTETDMSLHPLLQEIYKDLY |
| External Links | |
| GenBank ID Protein | CAA73033.1 |
| UniProtKB/Swiss-Prot ID | O18971 |
| UniProtKB/Swiss-Prot Entry Name | PPARG_BOVIN |
| PDB IDs | |
| GenBank Gene ID | Y12420 |
| GeneCard ID | PPARG |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |