| Identification |
|---|
| BMDB Protein ID
| BMDBP01883 |
| Secondary Accession Numbers
| None |
| Name
| Peroxisome proliferator-activated receptor gamma |
| Synonyms
|
Not Available
|
| Gene Name
| PPARG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| 22q24 |
| SNPs
| PPARG |
| Gene Sequence
|
>1518 bp
ATGGGTGAAACTCTGGGAGATGCTCTTATTGACCCAGAGAGTGAGCCCTTCGCTGTCACA
GTGTCTGCAAGGACCTCACAAGAAATTACCATGGTTGACACAGAGATGCCGTTTTGGCCC
ACCAACTTTGGGATCAGCTCCGTGGACCTTTCTATGATGGATGACCACTCCCATGCCTTT
GACATCAAGCCCTTCACCACCGTTGACTTCTCCAGCATTTCCACTCCGCACTATGAGGAC
ATTCCGTTCCCAAGAGCTGACCCGATGGTTGCAGATTATAAGTATGACCTGAAGCTCCAA
GAGTACCAAAGTGCAATCAAAGTGGAGCCTGTATCCCCACCTTATTATTCTGAAAAGACT
CAGCTGTACAGTAAGCCTCATGAAGAGCCTTCCAACTCCCTCATGGCCATTGAATGCCGG
GTCTGTGGGGATAAAGCGTCAGGGTTCCACTATGGAGTTCATGCTTGTGAAGGATGCAAG
GGTTTCTTCCGGAGGACAATCAGATTGAAACTTATTTACGATAGGTGTGATCTTAACTGT
CGGATCCACAAGAAAAGTAGAAATAAATGTCAGTACTGTCGGTTTCAGAAGTGCCTTGCT
GTGGGGATGTCTCATAATGCCATCAGGTTTGGGCGCATGCCACAGGCCGAGAAGGAGAAG
CTGTTAGCGGAGATCTCCAGCGATATCGACCAACTGAACCCAGAGTCTGCTGACCTCCGG
GCCCTGGCAAAGCATTTGTATGACTCGTACATAAAGTCCTTCCCGCTGACCAAAGCAAAG
GCGAGGGCGATCTTGACGGGAAAGACGACAGACAAATCACCGTTTGTTATCTATGACATG
AACTCCTTAATGATGGGAGAAGATAAAATCAAGTTCAAGCACATCAGTCCCCTGCAGGAG
CCCAGCAAAGAGGTGGCCATCCGCATCTTCCAGGGGTGTCAGTTTCGCTCCGTGGAAGCC
GTGCAGGAGATCACAGAGTACGCCAAGAATATCCCCGGCTTTGTGAACCTTGACTTGAAC
GACCAAGTAACTCTCCTAAAATACGGCGTGCACGAGATCATTTACACGATGCTGGCCTCC
TTGATGAATAAGGATGGGGTCCTCATATCCGAGGGCCAAGGATTCATGACAAGGGAGTTT
CTAAAGAGCCTGCGAAAGCCCTTTGGTGACTTTATGGAGCCCAAGTTCGAGTTTGCTGTG
AAGTTCAACGCACTGGAATTAGATGACAGCGACTTAGCAATATTTATAGCTGTCATTATT
CTCAGTGGAGACCGCCCAGGTTTGCTGAACGTGAAGCCCATTGAGGACATACAAGACAAT
CTGCTGCAAGCCTTGGAGCTGCAGCTCAAGCTGAACCACCCCGAGTCCTCCCAGCTCTTT
GCCAAGCTGCTCCAGAAAATGACAGACCTCAGACAGATTGTGACAGAACACGTGCAGCTG
TTGCAAGTAATAAAGAAAACAGAGACGGACATGAGTCTCCACCCACTCCTACAGGAAATC
TACAAGGACTTGTATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 505 |
| Molecular Weight
| 57579.0 |
| Theoretical pI
| 6.04 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 24-49
- 59-79
- 105-126
- 148-168
- 181-199
- 218-244
- 257-278
|
| Protein Sequence
|
>Peroxisome proliferator-activated receptor gamma
MGETLGDALIDPESEPFAVTVSARTSQEITMVDTEMPFWPTNFGISSVDLSMMDDHSHAF
DIKPFTTVDFSSISTPHYEDIPFPRADPMVADYKYDLKLQEYQSAIKVEPVSPPYYSEKT
QLYSKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHISPLQE
PSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
|
| External Links |
|---|
| GenBank ID Protein
| CAA73033.1 |
| UniProtKB/Swiss-Prot ID
| O18971 |
| UniProtKB/Swiss-Prot Entry Name
| PPARG_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Y12420 |
| GeneCard ID
| PPARG |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
