| Identification |
|---|
| BMDB Protein ID
| BMDBP01896 |
| Secondary Accession Numbers
| None |
| Name
| Sodium- and chloride-dependent creatine transporter 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC6A8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in creatine:sodium symporter activity |
| Specific Function
| Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| SLC6A8 |
| Gene Sequence
|
>1908 bp
ATGGCCAACAAGAGCACGGAGAACGGCATCTACAGCGTGTCCGGCGAGGAGAAGAAGGGC
CCCCTAATCGCGCCCGGGCCCGACGGAGCCCCGGCCAAGGGCGACGGCCCCGCAGCCCTG
GGGGCGCCCGGCAGCCTCCTGGCCGTTCCGCCGCGCGAGACCTGGACGCGCCAGATGGAC
TTCATCATGTCGTGCGTGGGCTTTGCCGTGGGCCTGGGCAACGTGTGGCGCTTCCCCTAC
CTGTGCTACAAGAACGGCGGAGGTGTGTTCCTTATTCCCTACATCCTGATCGCCCTGATT
GGAGGAATCCCCATCTTCTTCTTGGAGATCTCGCTGGGCCAGTTCATGAAGGCCGGCAGC
ATCAACGTCTGGAATATCTGCCCCCTGTTCAAAGGCCTGGGCTACGCCTCCATGGTGATC
GTCTTCTACTGCAACACCTATTACATCATGGTGCTGGCCTGGGGCTTCTATTATCTGGTG
AAGTCCTTCACCACCACGCTGCCCTGGGCCACGTGTGGCCACACGTGGAACACTCCCGAT
TGCGTGGAGATCTTCCGCCACGAAGACTGTGCCAATGCCACCATGGCCAACCTCACATGT
GACCAGCTTGCTGACCGCCGGTCCCCGGTCATCGAGTTCTGGGAGAACAAAGTCTTGCGG
CTCTCTGAAGGGCTGGAGGTGCCAGGGGCCCTCAACTGGGAGGTGACCCTGTGTCTGCTG
ACCTGCTGGGTGCTGGTCTACTTCTGTGTCTGGAAGGGGGTCAAGTCAACAGGCAAGATC
GTGTATTTCACCGCTACATTCCCCTATGTGGTCCTCGTTGTGCTGCTGGTGCGCGGAGTG
CTGCTACCTGGCGCTTTGGATGGCATCATCTACTATCTCAAGCCTGACTGGTCAAAGCTG
GCATCCCCTCAGGTATGGATCGACGCAGGGACACAGATCTTCTTCTCTTACGCCATCGGC
TTGGGGGCCCTCACCGCCCTGGGCAGCTACAATCGCTTCAACAACAACTGCTACAAGGAT
GCCATCATACTCGCCCTCATCAACAGCGGGACCAGCTTCTTTGCAGGCTTCGTGGTGTTC
TCCATCCTGGGCTTCATGGCCACAGAACAGGGCGTGCACATCTCCAAGGTAGCAGAATCA
GGGCCTGGCCTGGCTTTCATCGCCTATCCGCGGGCCGTCACGCTGATGCCCGTGGCCCCA
CTCTGGGCAGCTCTGTTCTTCTTCATGCTGTTGCTGCTTGGTCTGGACAGCCAGTTTGTA
GGTGTCGAAGGCTTCATCACTGGCTTGCTGGACCTCCTCCCAGCCTCCTACTACTTCCGA
TTCCAAAGGGAGATCTCCGTGGCCCTCTGTTGCACCATCTGCTTTGTCATCGACCTCTCC
ATGGTGACTGATGGCGGGATGTATGTCTTCCAGCTGTTTGACTACTACTCAGCCAGTGGC
ACCACACTGCTCTGGCAGGCCTTCTGGGAGTGTGTGGTGGTCGCCTGGGTGTACGGAGCT
GATCGCTTCATGGATGATGTGGCCTGCATGATCGGGTACCGACCTTGCCCCTGGATGAAA
TGGTGCTGGTCTTTCTTCACCCCACTGGTGTGCATGGGCATCTTCATCTTCAATGTGGTC
TACCATGAGCCGCTGGTCTACAACAATACCTACGTGTACCCGTGGTGGGGCGAGGCCGTG
GGCTGGGCCTTTGCGCTCTCCTCCATGCTATGTGTGCCCCTCCACCTCCTGGGCTGCCTC
CTCAGGGCCAAGGGGACCATGGCTGAGCGCTGGCAGCACCTGACGCAGCCCATCTGGGGC
CTCCACCACCTGGAATACAGAGCTCAAGACTCGGATGTCAGGGGCCTGACCACCCTGACC
CCAGTGTCTGAGAGCAGCAAGGTGGTGGTGGTGGAAAGCGTCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 635 |
| Molecular Weight
| 70676.0 |
| Theoretical pI
| 5.88 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 61-81
- 88-108
- 139-159
- 231-251
- 270-290
- 305-325
- 342-362
- 395-415
- 445-465
- 480-500
- 521-541
- 561-581
|
| Protein Sequence
|
>Sodium- and chloride-dependent creatine transporter 1
MANKSTENGIYSVSGEEKKGPLIAPGPDGAPAKGDGPAALGAPGSLLAVPPRETWTRQMD
FIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYILIALIGGIPIFFLEISLGQFMKAGS
INVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPD
CVEIFRHEDCANATMANLTCDQLADRRSPVIEFWENKVLRLSEGLEVPGALNWEVTLCLL
TCWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKL
ASPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVF
SILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFV
GVEGFITGLLDLLPASYYFRFQREISVALCCTICFVIDLSMVTDGGMYVFQLFDYYSASG
TTLLWQAFWECVVVAWVYGADRFMDDVACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVV
YHEPLVYNNTYVYPWWGEAVGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWG
LHHLEYRAQDSDVRGLTTLTPVSESSKVVVVESVM
|
| External Links |
|---|
| GenBank ID Protein
| AAB84029.1 |
| UniProtKB/Swiss-Prot ID
| O18875 |
| UniProtKB/Swiss-Prot Entry Name
| SC6A8_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF027197 |
| GeneCard ID
| SLC6A8 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
