| Identification |
|---|
| BMDB Protein ID
| BMDBP01899 |
| Secondary Accession Numbers
| None |
| Name
| Cation-dependent mannose-6-phosphate receptor |
| Synonyms
|
Not Available
|
| Gene Name
| M6PR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in mannose binding |
| Specific Function
| Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| M6PR |
| Gene Sequence
|
>840 bp
TTTGCCTGCTCTCTTGCACGTGACATGATGTCCCCCCTCCACAGCTCCTGGAGGACTGGC
CTGCTGCTGCTGCTGCTCTTCTCTGTGGCAGTCAGAGAATCTTGGCAGACAGAAGAGAAA
ACATGCGACCTGGTGGGAGAAAAGGGTAAAGAATCAGAGAAAGAGTTGGCTCTCCTGAAG
AGGCTGACACCGCTATTTAACAAAAGCTTTGAGAGCACCGTAGGCCAGAGCCCAGACATG
TACAGCTATGTGTTCCGGGTGTGCCGAGAAGCTGGCAACCACTCCTCTGGGGCAGGCCTG
GTGCAGATCAACAAAAGTAACGGGAAGGAGACGGTAGTTGGGAGATTCAACGAGACTCAG
ATCTTCAATGGAAGTAATTGGATCATGCTGATCTATAAAGGGGGTGATGAATATGACAAC
CACTGTGGCAGGGAGCAGCGGCGGGCAGTGGTGATGATCTCCTGCAATCGACACACCCTA
GCGGACAACTTTAACCCTGTGTCTGAGGAGCGAGGCAAAGTCCAAGATTGTTTCTACCTC
TTTGAGATGGACAGCAGCCTGGCGTGTTCCCCAGAGATCTCCCACCTTAGCGTGGGTTCT
ATCTTACTTGTCACGCTTGCATCACTGGTCGCAGTCTATATCATCGGGGGGTTCCTGTAC
CAGCGACTGGTGGTAGGAGCCAAAGGAATGGAGCAGTTTCCTCACTTGGCCTTCTGGCAG
GATCTTGGAAACCTGGTAGCAGATGGCTGTGACTTTGTATGCCGCTCTAAACCCCGAAAT
GTGCCTGCTGCCTATCGTGGTGTGGGGGATGATCAGCTGGGGGAGGAGTCAGAAGAAAGG
|
| Protein Properties |
|---|
| Number of Residues
| 279 |
| Molecular Weight
| 31201.0 |
| Theoretical pI
| 5.4 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cation-dependent mannose-6-phosphate receptor
MMSPLHSSWRTGLLLLLLFSVAVRESWQTEEKTCDLVGEKGKESEKELALLKRLTPLFNK
SFESTVGQSPDMYSYVFRVCREAGNHSSGAGLVQINKSNGKETVVGRFNETQIFNGSNWI
MLIYKGGDEYDNHCGREQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLA
CSPEISHLSVGSILLVTLASLVAVYIIGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVAD
GCDFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
|
| External Links |
|---|
| GenBank ID Protein
| AAA30634.1 |
| UniProtKB/Swiss-Prot ID
| P11456 |
| UniProtKB/Swiss-Prot Entry Name
| MPRD_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M17025 |
| GeneCard ID
| M6PR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
