| Identification |
|---|
| BMDB Protein ID
| BMDBP01910 |
| Secondary Accession Numbers
| None |
| Name
| Mannose-binding protein C |
| Synonyms
|
Not Available
|
| Gene Name
| MBL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| MBL |
| Gene Sequence
|
>750 bp
ATGTCGCTGTTTACATCACTTCCTTTTCTTCTCCTGACTGCGGTGACAGCATCTTGTGCA
GACACAGAAACAGAGAACTGTGAGAACATCCGGAAGACCTGCCCCGTGATTGCCTGTGGT
CCTCCGGGCATCAATGGCATCCCAGGCAAAGATGGGCGTGATGGTGCCAAGGGAGAAAAG
GGAGAACCAGGTCAAGGACTCAGAGGCTCGCAGGGCCCCCCTGGAAAGATGGGGCCTCAA
GGAACGCCAGGGATCCCTGGGATACCAGGACCAATAGGCCAAAAAGGAGACCCTGGAGAA
AATATGGGTGACTATATTCGCCTGGCTACTTCAGAAAGAGCAACTCTACAATCTGAATTG
AACCAGATCAAAAACTGGCTAATCTTCTCTCTGGGCAAAAGAGTTGGGAAGAAGGCATTT
TTTACCAATGGTAAAAAGATGCCTTTTAATGAAGTGAAGACTCTGTGTGCACAGTTCCAG
GGCCGTGTGGCCACCCCTATGAATGCTGAAGAAAACAGGGCCCTCAAGGATTTAGTCACT
GAAGAGGCCTTCCTGGGCATCACAGATCAGGAGACTGAAGGCAAATTTGTGGATCTGACA
GGAAAGGGGGTGACCTACCAAAACTGGAATGATGGCGAGCCTAACAACGCTTCTCCTGGG
GAGCACTGTGTGACACTTCTGTCGGACGGCACATGGAATGACATCGCTTGTTCCGCCTCC
TTTTTGACCGTCTGTGAATTCTCTCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 249 |
| Molecular Weight
| 26471.0 |
| Theoretical pI
| 4.83 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 151-173
- 179-212
- 232-265
- 285-302
- 309-328
- 449-469
- 489-515
- 535-553
- 589-607
- 613-635
- 647-671
|
| Protein Sequence
|
>Mannose-binding protein C
MSLFTSLPFLLLTAVTASCADTETENCENIRKTCPVIACGPPGINGIPGKDGRDGAKGEK
GEPGQGLRGSQGPPGKMGPQGTPGIPGIPGPIGQKGDPGENMGDYIRLATSERATLQSEL
NQIKNWLIFSLGKRVGKKAFFTNGKKMPFNEVKTLCAQFQGRVATPMNAEENRALKDLVT
EEAFLGITDQETEGKFVDLTGKGVTYQNWNDGEPNNASPGEHCVTLLSDGTWNDIACSAS
FLTVCEFSL
|
| External Links |
|---|
| GenBank ID Protein
| BAA18935.1 |
| UniProtKB/Swiss-Prot ID
| O02659 |
| UniProtKB/Swiss-Prot Entry Name
| MBL2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D73408 |
| GeneCard ID
| MBL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
