| Identification |
|---|
| BMDB Protein ID
| BMDBP01911 |
| Secondary Accession Numbers
| None |
| Name
| Cation-independent mannose-6-phosphate receptor |
| Synonyms
|
Not Available
|
| Gene Name
| IGF2R |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in receptor activity |
| Specific Function
| Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| 9q27-q28 |
| SNPs
| IGF2R |
| Gene Sequence
|
>7500 bp
ATGGAGGCGGCCGCCGGCCGGAGCTCGCACCTGGGGCCCGCGCCCGCCGGGCGCCCGCCG
CGGTGCCCGCTCCTGCTGCAGCTGCAGCTGCTGCTGCTGCTGCTGCTGCTGCCGCCGGGC
TGGGTTCCCGGGGCCGCGGGCACCCAGGGCGCCGAGTTCCCAGAGCTGTGCAGTTATACA
TGGGAAGCAGTGGATACCAAAAATAACATGCTTTATAAAATCAACATCTGTGGAAATATG
GGTGTTGCCCAGTGTGGACCATCAAGTGCTGTCTGTATGCATGACTTGAAGACAGACAGC
TTTCATTCTGTGGGTGACTCTCTTTTGAAAACAGCAAGCAGATCTCTTCTGGAATTTAAC
ACAACAGTGAACTGTAAGCAGCAGAATCACAAAATTCAGAGTAGCATCACCTTCTTATGT
GGGAAAACCTTGGGAACTCCCGAGTTTGTAACTGCAACAGATTGTGTGCATTACTTCGAG
TGGAGGACTACTGCAGCCTGCAAAAAGAATATATTTAAAGCGAATAAAGAGGTGCCCTGT
TACGCTTTCGACAGAGAGCTCAAGAAGCACGATTTAAACCCACTGATCAAGACCAGCGGT
GCTTACTTGGTGGACGACTCTGACCCGGACACATCTCTGTTCATCAATGTCTGCAGGGAC
ATAGAGGTGCTCCGGGCCTCGAGTCCACAAGTGCGCGTGTGTCCCACCGGCGCGGCCGCC
TGCCTGGTGCGAGGGGACCGCGCGTTCGACGTGGGCCGGCCCCAGGAGGGGCTGAAGCTC
GTGAGCAATGACAGGCTCGTCCTGAGTTACGTGAAGGAAGGGGCCGGCCAGCCCGACTTC
TGTGACGGCCACAGCCCGGCGGTGACCATCACGTTCGTGTGCCCGTCGGAGCGCAGAGAG
GGCACCATTCCCAAGCTCACAGCGAAATCCAACTGCCGCTTTGAGATCGAGTGGGTCACC
GAGTACGCCTGCCACAGGGATTACCTGGAAAGCCGGAGCTGCTCCCTGAGCAGCGCGCAG
CATGACGTGGCCGTCGACCTCCAGCCGTTGAGCCGGGTGGAAGCCTCAGACTCCTTGTTC
TACACCTCGGAGGCGGACGAGTATACATATTATTTGAGCATCTGCGGAGGAAGCCAAGCG
CCCATCTGTAATAAGAAAGATGCTGCAGTGTGCCAAGTGAAAAAGGCAGATTCCACTCAA
GTCAAAGTGGCCGGGAGACCCCAGAACCTGACCCTCCGGTACTCGGATGGAGACCTCACC
TTGATCTATTTCGGGGGTGAAGAGTGCAGCTCCGGCTTCCAGCGGATGAGTGTCATCAAC
TTCGAGTGCAATCAGACAGCAGGTAACAATGGCAGAGGGGCTCCTGTGTTCACCGGGGAG
GTGGACTGCACCTACTTCTTCACGTGGGATACGAAGTACGCCTGTGTCCACGAGAAGGAG
GCCCTGCTGTGCGGCGTCTCCGACGGGAAACAGCGCTTCGACCTGTCGGCGCTGGCCCGG
CACTCAGAACTGGAACAAAATTGGGAAGCTGTGGATGGCAGTCAGAGGGAAGCAGAAAAG
AAGCATTTCTTCATTAACATCTGCCACAGGGTCCTGCAGACGGGCCAGGCACGGGGCTGC
CCCGAAGACGCGGCCGTGTGTGCCGTGGATAAGAATGGAAGTAAAAATCTGGGCAGATTT
ATTTCTTCTCCCACCAGAGAGAAAGGAAATATTCAGCTCTCTTACTCAGATGGTGATGAG
TGCGGTGGTGGCCAGAAGATAATAACAAATATAACACTCATGTGCAAACCAGGTGATTTA
GAAAGTGCCCCGGTGCTGACAACCTCCAGGGCTGACGGCTGCTTCTACGAGTTTGAGTGG
CGCACGGCTGCAGCCTGCGTGCTCTCCAGGACCGAGGGGGACAACTGCACTGTCTTTGAC
TCCCAGGCAGGGTTTTCTTTCGACTTGACGCCTCTCACGAAGAAGGACGCCTACAAGGTC
GAGACGGACAAGTACGAGTTCCACATCAACGTGTGCGGCCCGGTGTCCGTGGGCGCCTGC
CCGCCGGACTCGGGGGCCTGTCAGGTGTCCAGGAGTGATAGGAAGTCTTGGAACTTGGGA
CGCAGCAATGCTAAGCTTTCGTATTACGACGGGATGATCCAGCTGACCTACAGGGACGGC
ACACCCTACAATAACGAGAAGCGCACGCCGAGAGCCACGCTCATCACCTTCCTCTGTGAC
CGAGACGCCGGAGTGGGTTTCCCCGAATATCAGGAGGAAGATAACTCTACATACAACTTC
CGGTGGTACACCAGTTACGCCTGCCCGGAGGAGCCGCTGGAGTGCATCGTGACTGACCCC
GTCACACTGGACCAGTACGACCTCTCCAGGCTAGCGAAATCCGAGGGCGGTCCTGGGGGA
AACTGGTACTCTCTGGACAACGGCGGGGCACGCAGCACGTGGCGGAAGTACTACATCAAC
GTGTGTCGTCCCCTGAACCCGGTGCCGGGCTGTGACCGCTACGCGTCCGCCTGTCAGATG
AAGTACCAGGGCGAGCAGGGCTCGTACTCTGAGACCGTCTCCATCAGCAACCTGGGGGTG
GCGAAGACGGGCCCCATGGTGGAGGACAGCGGCAGCCTGCTCCTGGAGTACGTCAACGGC
TCCGCCTGCACCACCAGCGACCAGAGGCGCACCACCTACACCACCAGGATCCACCTTGTC
TGCTCTACCGGCAGCCTGTATACCCATCCCATATTTTCTCTCAACTGGGAGTGTGTGGTC
AGCTTCCTGTGGAACACGGCGGCAGCCTGTCCTATCCGAATCACCACGGACATAGACCAG
GTCTGCTCCATCAAGGACCCCAACAGCGGGTACGTGTTTGATCTGAACCCACTGAACAAT
TCCCGAGGATACGTGGTTTTGGGCATCGGGAAGACGTTTCTGTTCAACGTGTGCGGTGAC
ATGCCCGCCTGTGGCACCCTGGATGGGAAGCCAGCTTCCGGCTGCGAGGCAGAAGTCCAG
ATGGACGACATGAAGACCCTGAAGCCGGGCAGGCTGGTGGGCCTGGAGAAGAGCCTGCAG
CTGTCCACCGAGGGCTTTATAACCCTGAACTACACGGGGCTTCCTTCCCACCCCAACGGG
AGGGCTGATGCCTTCATCATCCGCTTCGTCTGCAATGATGACGTTTACCCAGGGACACCC
AAGTTCCTGCACCAGGACATCGACTCTAGCCTGGGGATCCGGGACACTTTCTTCGAGTTT
GAAACCGCGCTGGCCTGTGTACCTTCTCCGGTAGATTGCCAAGTCACAGACCCCGCCGGG
AACGAGTATGATCTGAGTGGCCTGAGCAAGGCCAGGAAGCCGTGGACTGCGGTTGACACG
TTCGATGAGGGGAAGAAGAGGACCTTCTACCTGAGCGTGTGCACGCCTCTCCCGTACATT
CCCGGCTGCCACGGCACCGCTGTGGGGTGCTGCCTGGTGACGGAAGACAGCAAGTTGAAC
CTAGGCGTCGTGCAGATCAGTCCTCAGGTGGGCGCCAACGGGTCCCTGAGCCTCGTCTAC
GTCAACGGGGACAAGTGCAAGAACCAGCGTTTCTCCACCAGGATAAACCTCGAGTGTGCC
CACACAACGGGCTCCCCGACCTTTCAGCTCCAGAACGACTGTGAGTATGTGTTTCTCTGG
AGAACCGTGGAAGCCTGTCCCGTCGTGCGTGCGGAAGGAGACTACTGCGAGGTGAGAGAC
CCAAGGCACGGCAACCTGTATAACCTGATACCTCTTGGTCTGAACGACACTGTCGTGCGG
GCCGGCGAATACACCTATTACTTCCGCGTCTGCGGAGAGCTGACATCCGGCGTCTGCCCA
ACCAGTGACAAGTCCAAGGTCATCTCATCATGCCAGGAAAAGCGGGGACCCCAGGGATTT
CAAAAAGTGGCAGGTCTGTTTAATCAGAAGCTGACCTACGAGAATGGGGTGCTGAAGATG
AACTACACCGGGGGCGACACCTGCCACAAGGTGTACCAGCGTTCCACCACCATCTTTTTC
TACTGCGACCGCAGCACGCAGGCGCCCGTGTTTCTCCAGGAGACGTCCGATTGCTCCTAC
CTGTTTGAGTGGCGCACGCAGTACGCCTGCCCGCCCTACGACCTGACCGAGTGTTCGTTC
AAAAACGAGGCTGGGGAAACCTACGACCTCTCGTCTCTGTCGAGGTACAGCGACAACTGG
GAGGCTGTCACGGGCACAGGGTCCACCGAGCACTACCTCATCAACGTGTGCAAGTCCCTG
TCCCCGCAGGCTGGCTCAGATCCGTGCCCTCCGGAGGCGGCCGTGTGTCTGCTGGGCGGC
CCCAAGCCCGTGAACCTGGGCAGGGTGCGGGACAGTCCTCAGTGGAGCCAGGGCTTGACC
CTCCTGAAGTACGTTGACGGTGACTTGTGTCCAGACCAGATTCGGAAGAAGTCAACCACC
ATCCGCTTCACGTGCAGCGAGAGCCACGTGAACTCCAGGCCCATGTTCATCAGCGCTGTG
GAGGACTGCGAATACACCTTCTCCTGGCCCACGGCCGCCGCCTGCGCGGTCAAGAGCAAC
GTGCACGACGACTGCCAGGTCACCAACCCCGCCACGGGACACCTGTTTGACCTGAGCTCT
CTGAGCGGCCGGGCCGGCTTCACCGCCGCCTACAGCGAGAAGGGGTTAGTCTACCTCAGC
GTGTGCGGGGACAACGAGAACTGCGCCAACGGCGTGGGGGCCTGCTTTGGGCAGACCAGG
ATCAGCGTGGGCAAGGCGAGCAAGAGGCTGACCTACGTGGACCAGGTCTTGCAACTGGTG
TATGAGGGCGGCTCCCCCTGCCCCTCCAAGACCGGCCTGAGCTACAAGAGCGTCATCAGC
TTCGTGTGCAGGCCTGAGGTCGGGCCCACCAACAGGCCCATGCTGATCTCCCTGGACAAG
CGCACGTGCACGCTTTTCTTCTCCTGGCACACACCCCTGGCCTGCGAGCAGACGACCGAG
TGCTCCGTGAGGAACGGCAGCTCCCTCATCGACCTGTCCCCACTCATCCACCGCACCGGG
GGTTACGAAGCATACGATGAGAGTGAGGACGACGGCTCCGACACCAGCCCTGACTTCTAC
ATCAACATCTGCCAGCCGCTCAACCCCATGCACGGGTTGGCCTGCCCCGCCGGCACGGCC
GTGTGCAAGGTTCCCGTGGACGGCCCCCCGATAGATATTGGCCGAGTGGCAGGACCTCCG
ATCCTCAATCCCATAGCCAACGAAGTTTACTTGAACTTTGAAAGCAGCACTCCTTGCTTG
GCGGACCGGCACTTCAACTACACCTCACTGATCACGTTCCACTGTAAGCGGGGCGTGAGC
ATGGGAACGCCAAAACTGCTGAGGACCAGTGTGTGTGACTTCGTGTTTGAGTGGGAGACT
CCTCTGGTCTGTCCCGACGAAGTGAAGACGGACGGCTGCTCCCTCACGGACGAACAGCTG
TACTACAGCTTCAACCTGTCCAGCCTCTCCAAGAGCACCTTCAAGGTGACCCGAGGCCCG
CACACCTACAGTGTGGGGGTGTGCACCGCAGCCGCAGGCCTGGACGAAGGAGGCTGCAAG
GACGGTGCTGTCTGCCTGCTGTCCGGGAGCAAGGGGGCGTCTTTCGGGCGGCTGGCGTCC
ATGAAGCTGGACTACAGGCATCAGGACGAAGCTGTCATCCTGAGTTACGCCAACGGAGAC
ACTTGCCCTCCGGAAACTGAGGACGGCGAGCCGTGTGTGTTCCCCTTCGTGTTCAACGGG
AAGAGCTACGAGGAGTGTGTTGTGGAGAGCAGGGCCAGGCTCTGGTGCGCGACCACCGCC
AACTACGACAGAGACCACGAGTGGGGCTTCTGCAAGCACTCCACCAGCCACCGGACGTCC
GTCATCATCTTCAAGTGTGACGAGGACGCCGACGTGGGGCGGCCCCAGGTCTTCAGCGAG
GTGCGCGGCTGTGAGGTGACCTTCGAGTGGAAGACGAAGGTGGTCTGCCCCCCGAAGAAG
ATGGAGTGCAAGTTCGTCCAGAAGCACCGGACCTACGACCTGCGGCTGCTCTCGTCCCTC
ACCGGCTCCTGGTCCTTCGTCCACAACGGAGCCTCGTACTACATCAACCTGTGTCAGAAA
ATATACAAGGGACCCCAGGACTGCTCGGAGAGAGCCAGCGTGTGCAAAAAGAGCACCTCT
GGCGAGGTGCAGGTCCTCGGGCTCGTTCACACACAGAAGCTGGATGTTGTAGATGACAGA
GTCATCGTAACTTACTCTAAAGGCCACTACTGTGGGGACAATAAGACAGCGTCTGCTGTC
ATCGAGCTGACCTGTGCCAAGACAGTGGGGCGGCCTTCGTTCACGAGGTTCGACGTCGAC
AGCTGCACCTACCACTTCAGCTGGGACTCACGAGCGGCCTGCGCCGTGAAGCCTCAGGAG
GTGCAGATGGTGAATGGGACCATCACCAACCCGGCCAACGGCCGGAGCTTCAGCCTCGGG
GATATTTACTTCAAACGATTCAGCGCCTCTGGGGACGTGAGAACCAACGGGGACAGGTAC
ATCTACGAGATCCAGCTGTCGTCCATCACGGGCTCCAGCAGCCCCGCCTGCTCTGGGGCC
AGCATCTGCCAGAGGAAGGCCAACGACCAGCACTTCAGTCGCAAAGTCGGAACCTCCAAC
CAAACCAGATACTACGTTCAAGATGGCGACCTGGATGTGGTGTTCACCTCGTCCTCCAAG
TGTGGAAAAGACAAGACAAAGTCTGTGTCCTCCACCATCTTCTTCCACTGTGACCCCCTG
GTGAAGGACGGGATCCCCGAGTTCAGCCACGAGACTGCCGACTGCCAGTACCTCTTCTCC
TGGCACACCTCTGCCGTGTGCCCGCTGGGGGCGGGCTTCGACGAGGAGATCGCAGGGGAT
GACGCCCAGGAGCACAAAGGGCTCTCAGAGCGCAGCCAGGCGGTCGGGGCAGTGCTCAGC
CTGCTGCTGGTGGCACTCACCGCCTGCCTGCTCACCCTGCTGCTGTACAAGAAGGAGCGC
CGGGAGATGGTAATGAGCAGGCTTACCAACTGCTGCCGCCGGAGCGCGAACGTGTCCTAC
AAGTACTCGAAGGTGAACAAGGAGGAGGAGGCCGACGAGAACGAGACCGAGTGGCTGATG
GAGGAGATCCAGCCGCCGGCGCCGCGGCCCGGGAAGGAGGGCCAGGAGAACGGGCACGTG
GCCGCCAAGTCGGTGAGAGCTGCCGACACGCTGAGCGCCCTGCACGGCGACGAGCAGGAT
AGCGAGGACGAGGTCCTGACGCTGCCCGAGGTGAAGGTGCGCCCGCCAGGCCGGGCTCCT
GGTGCCGAAGGTGGCCCCCCGCTGCGGCCACTGCCTCGGAAGGCGCCACCGCCGCTGCGG
GCGGACGACCGGGTGGGGCTGGTGCGTGGGGAGCCGGCGCGCCGGGGGCGGCCCCGGGCG
GCGGCCACGCCCATCAGCACCTTCCACGACGACAGCGACGAGGACCTCCTGCACGTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 2499 |
| Molecular Weight
| 274529.0 |
| Theoretical pI
| 5.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cation-independent mannose-6-phosphate receptor
MEAAAGRSSHLGPAPAGRPPRCPLLLQLQLLLLLLLLPPGWVPGAAGTQGAEFPELCSYT
WEAVDTKNNMLYKINICGNMGVAQCGPSSAVCMHDLKTDSFHSVGDSLLKTASRSLLEFN
TTVNCKQQNHKIQSSITFLCGKTLGTPEFVTATDCVHYFEWRTTAACKKNIFKANKEVPC
YAFDRELKKHDLNPLIKTSGAYLVDDSDPDTSLFINVCRDIEVLRASSPQVRVCPTGAAA
CLVRGDRAFDVGRPQEGLKLVSNDRLVLSYVKEGAGQPDFCDGHSPAVTITFVCPSERRE
GTIPKLTAKSNCRFEIEWVTEYACHRDYLESRSCSLSSAQHDVAVDLQPLSRVEASDSLF
YTSEADEYTYYLSICGGSQAPICNKKDAAVCQVKKADSTQVKVAGRPQNLTLRYSDGDLT
LIYFGGEECSSGFQRMSVINFECNQTAGNNGRGAPVFTGEVDCTYFFTWDTKYACVHEKE
ALLCGVSDGKQRFDLSALARHSELEQNWEAVDGSQREAEKKHFFINICHRVLQTGQARGC
PEDAAVCAVDKNGSKNLGRFISSPTREKGNIQLSYSDGDECGGGQKIITNITLMCKPGDL
ESAPVLTTSRADGCFYEFEWRTAAACVLSRTEGDNCTVFDSQAGFSFDLTPLTKKDAYKV
ETDKYEFHINVCGPVSVGACPPDSGACQVSRSDRKSWNLGRSNAKLSYYDGMIQLTYRDG
TPYNNEKRTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECIVTDP
VTLDQYDLSRLAKSEGGPGGNWYSLDNGGARSTWRKYYINVCRPLNPVPGCDRYASACQM
KYQGEQGSYSETVSISNLGVAKTGPMVEDSGSLLLEYVNGSACTTSDQRRTTYTTRIHLV
CSTGSLYTHPIFSLNWECVVSFLWNTAAACPIRITTDIDQVCSIKDPNSGYVFDLNPLNN
SRGYVVLGIGKTFLFNVCGDMPACGTLDGKPASGCEAEVQMDDMKTLKPGRLVGLEKSLQ
LSTEGFITLNYTGLPSHPNGRADAFIIRFVCNDDVYPGTPKFLHQDIDSSLGIRDTFFEF
ETALACVPSPVDCQVTDPAGNEYDLSGLSKARKPWTAVDTFDEGKKRTFYLSVCTPLPYI
PGCHGTAVGCCLVTEDSKLNLGVVQISPQVGANGSLSLVYVNGDKCKNQRFSTRINLECA
HTTGSPTFQLQNDCEYVFLWRTVEACPVVRAEGDYCEVRDPRHGNLYNLIPLGLNDTVVR
AGEYTYYFRVCGELTSGVCPTSDKSKVISSCQEKRGPQGFQKVAGLFNQKLTYENGVLKM
NYTGGDTCHKVYQRSTTIFFYCDRSTQAPVFLQETSDCSYLFEWRTQYACPPYDLTECSF
KNEAGETYDLSSLSRYSDNWEAVTGTGSTEHYLINVCKSLSPQAGSDPCPPEAAVCLLGG
PKPVNLGRVRDSPQWSQGLTLLKYVDGDLCPDQIRKKSTTIRFTCSESHVNSRPMFISAV
EDCEYTFSWPTAAACAVKSNVHDDCQVTNPATGHLFDLSSLSGRAGFTAAYSEKGLVYLS
VCGDNENCANGVGACFGQTRISVGKASKRLTYVDQVLQLVYEGGSPCPSKTGLSYKSVIS
FVCRPEVGPTNRPMLISLDKRTCTLFFSWHTPLACEQTTECSVRNGSSLIDLSPLIHRTG
GYEAYDESEDDGSDTSPDFYINICQPLNPMHGLACPAGTAVCKVPVDGPPIDIGRVAGPP
ILNPIANEVYLNFESSTPCLADRHFNYTSLITFHCKRGVSMGTPKLLRTSVCDFVFEWET
PLVCPDEVKTDGCSLTDEQLYYSFNLSSLSKSTFKVTRGPHTYSVGVCTAAAGLDEGGCK
DGAVCLLSGSKGASFGRLASMKLDYRHQDEAVILSYANGDTCPPETEDGEPCVFPFVFNG
KSYEECVVESRARLWCATTANYDRDHEWGFCKHSTSHRTSVIIFKCDEDADVGRPQVFSE
VRGCEVTFEWKTKVVCPPKKMECKFVQKHRTYDLRLLSSLTGSWSFVHNGASYYINLCQK
IYKGPQDCSERASVCKKSTSGEVQVLGLVHTQKLDVVDDRVIVTYSKGHYCGDNKTASAV
IELTCAKTVGRPSFTRFDVDSCTYHFSWDSRAACAVKPQEVQMVNGTITNPANGRSFSLG
DIYFKRFSASGDVRTNGDRYIYEIQLSSITGSSSPACSGASICQRKANDQHFSRKVGTSN
QTRYYVQDGDLDVVFTSSSKCGKDKTKSVSSTIFFHCDPLVKDGIPEFSHETADCQYLFS
WHTSAVCPLGAGFDEEIAGDDAQEHKGLSERSQAVGAVLSLLLVALTACLLTLLLYKKER
REMVMSRLTNCCRRSANVSYKYSKVNKEEEADENETEWLMEEIQPPAPRPGKEGQENGHV
AAKSVRAADTLSALHGDEQDSEDEVLTLPEVKVRPPGRAPGAEGGPPLRPLPRKAPPPLR
ADDRVGLVRGEPARRGRPRAAATPISTFHDDSDEDLLHV
|
| External Links |
|---|
| GenBank ID Protein
| AAA30455.1 |
| UniProtKB/Swiss-Prot ID
| P08169 |
| UniProtKB/Swiss-Prot Entry Name
| MPRI_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| J03527 |
| GeneCard ID
| IGF2R |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
