| Identification |
|---|
| BMDB Protein ID
| BMDBP01930 |
| Secondary Accession Numbers
| None |
| Name
| SPARC |
| Synonyms
|
Not Available
|
| Gene Name
| SPARC |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| SPARC |
| Gene Sequence
|
>915 bp
ATGAGGGCCTGGATCTTCTTTCTCCTTTGCCTGGCCGGGAGGGCCTTGGCAGCCCCTCAA
CAGGAAGCCTTGCCTGATGAGACAGAAGTGGTGGAAGAAACCGTGGCCGAGGTGGCCGAG
GTACCCGTGGGAGCCAACCCCGTCCAGGTGGAAGTAGGAGAATTCGATGATGGTGCTGAG
GAAACCGAAGAGGAGGTGGTGGCCGAGAACCCCTGCCAGAACCACCACTGCAAACACGGC
AAGGTGTGCGAACTGGACGAGAACAACACCCCCATGTGTGTGTGCCAGGACCCCACCAGC
TGCCCTGCCCCCATCGGCGAGTTTGAGAAGGTGTGCAGCAACGACAACAAGACCTTCGAC
TCTTCCTGCCACTTCTTTGCCACCAAGTGCACACTGGAGGGCACCAAGAAGGGCCACAAA
CTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCCTGCCTGGACTCCGAGCTG
ACTGAATTCCCCTTGCGCATGCGGGACTGGCTTAAGAACGTCCTGGTCACGCTGTACGAG
AGGGACGAGGACAACAACCTCCTGACCGAGAAGCAGAAGCTGCGAGTGAAAAAGATCCAC
GAGAATGAGAAGCGCCTGGAGGCTGGCTGCGACCATCCTGTGGAACTGCTGGCCCGGGAC
TTCGAGAAGAACTACAACATGTACATCTTCCCTGTGCACTGGCAGTTCGGGCAGCTGGAT
CAGCACCCCATTGACGGGTACCTGTCTCACACCGAGCTGGCCCCACTGCGCGCCCCCCTT
ATCCCCATGGAACACTGCACCACCCGCTTTTTCGAGACATGTGACCTGGACAACGACAAG
TACATCGCCCTGGACGAGTGGGCCGGCTGCTTCGGCATCAAGGAGAAGGACATCGACAAG
GACCTCGTGATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 303 |
| Molecular Weight
| 34613.0 |
| Theoretical pI
| 4.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 44-64
- 89-109
- 215-235
- 241-261
- 391-411
|
| Protein Sequence
|
>SPARC
MRAWIFFLLCLAGRALAAPQQEALPDETEVVEETVAEVAEVPVGANPVQVEVGEFDDGAE
ETEEEVVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAPIGEFEKVCSNDNKTFD
SSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYE
RDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQ
HPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKEKDIDKD
LVI
|
| External Links |
|---|
| GenBank ID Protein
| AAA30678.1 |
| UniProtKB/Swiss-Prot ID
| P13213 |
| UniProtKB/Swiss-Prot Entry Name
| SPRC_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| J03233 |
| GeneCard ID
| SPARC |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
