| Identification |
|---|
| BMDB Protein ID
| BMDBP01934 |
| Secondary Accession Numbers
| None |
| Name
| Cytosolic iron-sulfur assembly component 3 |
| Synonyms
|
Not Available
|
| Gene Name
| CIAO3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in iron-sulfur cluster assembly |
| Specific Function
| Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| CIAO3 |
| Gene Sequence
|
>1089 bp
ATGGCGTCGCCCTTCAGCGGGGCCCTGCAGCTGACGGACTTGGACGACTTCATCGCGCCG
TCTCAGGACTGCATCAAGCCCATGAAGGTGGATAGGAGGCCTGGAAGCGGCGTGGCCAAG
ATCCACATCGAAGATGACGGGAGTTACTTCCAAGTCAGTCAGGATGGAGGGATGAAGAAG
CTGGAGAAGGCCAAGATCTCGCTGGACGACTGCCTGGCGTGCAGTGGCTGTGTCACCTCA
GCGGAGACTGTGCTTATCACTCAGCAGAGCCACGAGGAGCTGCGGAAGGTTCTAGGTGCC
AATAAGACGGCAGCACCTGATCAGCAGAAGCTGGTTGTCATCTCGGTCTCGCCCCAGTCC
AGAGCGTCACTGGCTGTGAGGTTTCAGCTGAATCCTACGGACACCGCCAGGAAATTAACA
GCATTCTTTAAAAAAATAGGCGCACACTACGTGTTCGACACTGCCTTCTCAAGGAACTTC
AGCCTCCTCGAGAGCCAGCGGGAGTTTGTGCGGCGGTTCCGAGGACAGGCCGACCCCGAG
CAGGCCCTGCCCGTGCTGACTTCTGCCTGCCCAGGCTGGATCTGCTACGCGGAGAAGACC
CACGGGAGCACCCTCCTCCCCCACATCAGCACGGCACGGTCCCCGCAGCAGGTCATGGGC
TCCCTGGTCAAGGACTTCTTCGCCCAGCAGCAGCATCTGACCCCCGACAAGGTCTACCAC
GCGACAGTAATGCCCTGCTACGACAAAAAGCTGGAAGCCTCCAGACCCGACTTCTTCAGC
CAGGAGCACCAGACACGCGACGTGGACTGTGTCATCACCACAGGCGAAGTCTTCAAGCTG
CTGGAAGAAGAAGGGGTCTCGCTGTCAGAGCTGGAGCCGGCTCCTCTGGACAGTCTGTAC
GTCATCACCGGCCCTGTTGGAGGAGCTGTAAGCTCACCCAGCACTGGGTGCTCTCCACCC
GGGGGGTCTCGCAGGTCTGGGCAGGCGGCAGGAGGGGCCGTGGCCCTCAACGCAGGCACT
GGCCTCCTCCCTTTTCTCTGGCCTGGCCTCCCTCGGCCCCTCGTGTGTCTCAGTGTCCAA
GATACTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 476 |
| Molecular Weight
| 52606.0 |
| Theoretical pI
| 6.82 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytosolic Fe-S cluster assembly factor NARFL
MASPFSGALQLTDLDDFIAPSQDCIKPMKVDRRPGSGVAKIHIEDDGSYFQVSQDGGMKK
LEKAKISLDDCLACSGCVTSAETVLITQQSHEELRKVLGANKTAAPDQQKLVVISVSPQS
RASLAVRFQLNPTDTARKLTAFFKKIGAHYVFDTAFSRNFSLLESQREFVRRFRGQADPE
QALPVLTSACPGWICYAEKTHGSTLLPHISTARSPQQVMGSLVKDFFAQQQHLTPDKVYH
ATVMPCYDKKLEASRPDFFSQEHQTRDVDCVITTGEVFKLLEEEGVSLSELEPAPLDSLC
SSASAQEPTSHQGGGSGGYLEHVFRHAAQELFGIHVTEVTYRPLRNKDLQEVILEREGQV
LLHFAAAYGFRNIQNLVQKLKRGRCPYHYVEVMACPAGCLNGGGQLKAPDMPGKELLQQV
ERLYGLVRTEAPEDAPGIQELYERWLQGAGSERAGRLLHTSYHAVEKAGSGLSIRW
|
| External Links |
|---|
| GenBank ID Protein
| AAI23769.1 |
| UniProtKB/Swiss-Prot ID
| A4FV58 |
| UniProtKB/Swiss-Prot Entry Name
| CIAO3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123768 |
| GeneCard ID
| CIAO3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
