| Identification |
|---|
| BMDB Protein ID
| BMDBP01993 |
| Secondary Accession Numbers
| None |
| Name
| Cyclic AMP-dependent transcription factor ATF-4 |
| Synonyms
|
Not Available
|
| Gene Name
| ATF4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein dimerization activity |
| Specific Function
| Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| ATF4 |
| Gene Sequence
|
>1047 bp
ATGGCCGAGATGAGCTTTCTGAGCAGCGAGGTGTTAGGGGGGGACTTCGTGTCCCCCTTC
GACCAGTTGGGTTTGGGGGCTGAAGAGAGCCTAGGTCTCCTAGATGACAACCTGGAGGTG
GCCAAGCACTTCAAACATCATGGGTTCTCCTGCGACAAGGCTAAGGCAGGCTCCTCCGAA
TGGCTGGCTGTGGATTGGTTGGTCTCAGACAACAGCAAGGAGGATGCTTTCTCCGGGACA
GATTGGATGGTGGAGAAAATGGATTTGAAGGAGTTTGATTTTGATATCCTGTTCAGTAAA
GATGACCTGGAAACCATGCCAGATGAGCTCTTGGCCACGTTGGATGACACGTGTGATCTC
TTTCAGCCCCTAGTCCAGGAGACTAACAAGGAGCCCCCCCAGATAGTAAACCCAATTGGC
CATCTTCCAGAAGGTTTACCAACAATTGACCAGGGTGCCCCCTTCACTTTCTTTCAACCT
CTTCCCCCTTCCCCAGGGACCCTGTCTTCCACTCCAGATCATTCCTTTAGTTTAGAGCTA
TGCAGTGAAGTGGTTATCCCTGAAGGAGATAGCAAGCCAGACTCCACCACTACTGGGTTT
CCTCAATGCATAAAAGAGGAGGATGCCCCCTCAGATAATGATAGTGGCATCTGTATGAGC
CCTGACTCCTCTCTGGGCTCTCCCCAGGATAGCCCTTCCACCTCCAGGGGCTCTCCAAAT
AAGAGCCTGCTATCTCCAGGTGCCCTCAGTGGCTCTTCCCGCCCCAAACCCTACGACCCT
CCTGGAGAGAAGATGGTAGCAGCAAAAGTCAAGGGTGAGAAGCTAGACAAGAAGCTGAAG
AAAATGGAGCAGAACAAGACAGCAGCTACTAGGTACCGCCAGAAGAAGAGGGCGGAACAG
GAGGCCCTCACTGGTGAATGTAAAGAGCTAGAAAAAAAGAATGAGGCTCTGAAAGAGAAG
GCAGATTCCTTGGCCAAGGAGATCCAGTATCTTAAAGATCAGATAGAAGAGGTTCGCAAA
GCAAGGGAGAAGAAAAGGGTCCTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 348 |
| Molecular Weight
| 38245.0 |
| Theoretical pI
| 4.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cyclic AMP-dependent transcription factor ATF-4
MAEMSFLSSEVLGGDFVSPFDQLGLGAEESLGLLDDNLEVAKHFKHHGFSCDKAKAGSSE
WLAVDWLVSDNSKEDAFSGTDWMVEKMDLKEFDFDILFSKDDLETMPDELLATLDDTCDL
FQPLVQETNKEPPQIVNPIGHLPEGLPTIDQGAPFTFFQPLPPSPGTLSSTPDHSFSLEL
CSEVVIPEGDSKPDSTTTGFPQCIKEEDAPSDNDSGICMSPDSSLGSPQDSPSTSRGSPN
KSLLSPGALSGSSRPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKRAEQ
EALTGECKELEKKNEALKEKADSLAKEIQYLKDQIEEVRKAREKKRVL
|
| External Links |
|---|
| GenBank ID Protein
| AAI02237.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZCH6 |
| UniProtKB/Swiss-Prot Entry Name
| ATF4_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102236 |
| GeneCard ID
| ATF4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
