| Identification |
|---|
| BMDB Protein ID
| BMDBP01994 |
| Secondary Accession Numbers
| None |
| Name
| Cyclic AMP-responsive element-binding protein 3 |
| Synonyms
|
Not Available
|
| Gene Name
| CREB3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein dimerization activity |
| Specific Function
| Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death. Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Associates with chromatin to the HERPUD1 promoter. Also induces transcriptional activation of chemokine receptors. Functions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| CREB3 |
| Gene Sequence
|
>1131 bp
ATGTCTCATATGGAGCTGGCGTTGGACCCGGGTGACCACGACCTGCTAGGCTTTCTGCTA
GAAGAAAGCGGTGGTTTGGGTGCGGCGCCCGACGAGGCCTTGACGTCTCCGCCGGATTGG
GAGCTGCCACTTTCTGAGCCTGTTAATTTGAACCCTGTGCAGTCTCTGAGCGACTGGGAC
GTGGAGGATTTCCTGAGCTGCCTGCCGAGTCCCCCAGCAGTGTTGAACGTTTTCAGCAAC
TCTGACCCCTGTCTTGTCCAGCATGACCACACCTATTCTCTGTCACAAGAGCATGTCTCC
ATCGATCTCGATAATGAGAGCTATGAAAAAGAGAGGGCTCAGATGACTCCACTGCGTGTG
GAGGAGCCGGCAGATCAGGAGATTGCTAGGCTGATACTGACTGAGGAGGAGAAAAGGCTG
TTGGAGAAGGAGGGGCTTACTTTGCCTGGGATGCTTCCGCTCACTAAGATGGAGGAACAA
GTTCTGAAACGGGTGCGGAGGAAGATTCGAAACAAAAAGTCTGCTCAAGAGAGCCGCAGG
AAGAAGAAGGTGTATGTGGGGGGTTTAGAAAGCAGGGTCCTGAAATACACAGCCCAGAAT
CTGGAGCTACAGAACAAAGTACAGCTCCTGGAGGAACAGAATCTGTCCCTTTTGGATCAG
CTGAGGAGACTCCAGGCCATGGTGATTCAGACAGCAAACAAAGCCAGCAGCAGCAGCACC
TGTGTCTTGGTTCTACTGTTCTCCTTCTGTCTCCTCCTCGTACCTGCTATGTACTCCTCG
GACACAAGGGGGAGCCTGCCGGCTGAGCACAGAGTGTTGTCCCGTCAGCTTCGTGCCCTC
CCCAGCGAGGACCCCCCGCAGCTGGAGCCACCTGCCCTGCAGTCAGAGGTACCAAAGGAC
AGCTTGAACCCTGAGCTCCAGGCTGCTAGCAACTCTTGCTGCCTCTTCCATCTCATGCCC
CAGGCTCCTAGAGCAGAGCCTCCCCTGCAATTGCCACTGCCTGATGGTTTCTCAGGGTGC
TCCTGCCCAGATTCCATATCTCCCCTGCATGCAAATCTCACAAGAGAGGAAGGATGGCTC
CCTACTCCCAGCCCCACATCTGTTATCTTGCAGGGCAGATACTCAGGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 368 |
| Molecular Weight
| 40912.0 |
| Theoretical pI
| 4.67 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cyclic AMP-responsive element-binding protein 3
MSHMELALDPGDHDLLGFLLEESGGLGAAPDEALTSPPDWELPLSESLSDWDVEDFLSCL
PSPPAVLNVFSNSDPCLVQHDHTYSLSQEHVSIDLDNESYEKERAQMTPLRVEEPADQEI
ARLILTEEEKRLLEKEGLTLPGMLPLTKMEEQVLKRVRRKIRNKKSAQESRRKKKVYVGG
LESRVLKYTAQNLELQNKVQLLEEQNLSLLDQLRRLQAMVIQTANKASSSSTCVLVLLFS
FCLLLVPAMYSSDTRGSLPAEHRVLSRQLRALPSEDPPQLEPPALQSEVPKDSLNPELQA
ASNSCCLFHLMPQAPRAEPPLQLPLPDGFSGCSCPDSISPLHANLTREEGWLPTPSPTSV
ILQGRYSG
|
| External Links |
|---|
| GenBank ID Protein
| AAX08756.1 |
| UniProtKB/Swiss-Prot ID
| Q8SQ19 |
| UniProtKB/Swiss-Prot Entry Name
| CREB3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020739 |
| GeneCard ID
| CREB3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
