Showing Protein CREB-regulated transcription coactivator 2 (BMDBP01998)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP01998 |
| Secondary Accession Numbers | None |
| Name | CREB-regulated transcription coactivator 2 |
| Synonyms | Not Available |
| Gene Name | CRTC2 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Not Available |
| Specific Function | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 3 |
| Locus | Not Available |
| SNPs | CRTC2 |
| Gene Sequence |
>2082 bp ATGGCGACGTCGGGAGCGAATGGGCCCGGTTCGGCCACGGCCTCAGCTTCCAATCCGCGT AAGTTTAGTGAGAAGATCGCGCTGCAGAAGCAGCGTCAGGCCGAGGAGACGGCGGCCTTC GAGGAGGTGATGATGGACATCGGCTCCACCCGGTTACAGGCCCAAAAACTTCGGCTGGCA TACACAAGGAGCTCCCACTATGGTGGCTCTCTGCCCAATGTGAACCAGATTGGCTGTGGC CTAGCCGAGTTCCAGAGCCCCCTCCACTCCCCTCTGGATTCATCTCGGAGCACTCGACAT CACGGGCTGGTGGAACGGGTGCAGCGAGATCCCCGAAGAATGGTGTCCCCGCTTCGCCGC TACGCCCGCCACATTGACAGCTCTCCCTATAGTCCTGCCTATTTATCTCCTCCCCCGGAG TCCAGCTGGCGGAGGACAATGCCCTGGGGCAGTTTCCCTGCAGAGAAGGGACAGTTGTTT CGACTACCATCTGCACTTAACAGGACAAGCTCTGACTCTGCCCTTCACACAAGCGTGATG AACCCCAGCCCTCAGGACACGTATCCAAGCCCTGCAGCCCCCAGCGTCCTGCCGAGCCGC CGTGGAGGTTGTCTGGACGGCGAGACGGACTCCAAAGTCCCTGCTATTGAGGAGAACTTG CTAGATGATAAGCACTTGTTGAAACCATGGGATGCTAAGAAGCTGTCCTCGTCCTCCTCC CGACCTCGGTCCTGTGAAGTCCCTGGAATTAACATCTTCCCGTCTCCTGACCAGCCTGCC ACTGTGCCTGTCCTCCCACCTGCCATGAACACGGGAGGCTCCCTACCTGACCTCACCAAC CTGCACTTTCCCCCACCGCTACCCACCCCCCTGGACCCAGAGGAGACAGCCTATCCCAGC CTGAGTGGGGGCAGCAGTACCTCCAATTTGACCCACACCATGACCCACCTGGGCATCAGC GGGGGCCTGGCCCTGGGCCCGGGCTATGATGCGCCAGGACTTCATTCACCTCTCAGCCAC CCATCCTTTCAGTCCTCCCTAAGCAATCCCAACCTCCAGGCTTCCCTGAGCAGTCCTCAG CCCCAGCTCCAGGGCTCCCACAGTCACCCCTCACTGCCTGCTTCCTCCTTGGCTCGCCAC GCACTGCCCACCACCTCCCTGGGCCACCCCTCGCTCAGTGCCCCGGCCCTCTCCTCCTCC TCTTCCTCCTCTTCCGCTTCCTCTCCGGTGCTGGGGGCCCCCGCTTACCCAGCTTCTGCC CCTGGGGCCTCCCCCCGCCACCGCCGTGTGCCCCTCAGTCCCCTGAGTTTGCCCGCGGGC CCAGCCGACGCCAGAAGGTCCCAACAGCAACTGCCCAAACAGTTTTCGCCAACAATGTCA CCCACCTTGTCTTCCATCACTCAGGGCGTCGCCCTGGATACCAGTAAGCTGCCCACCGAC CAGCGGCTGCCTCCATACCCATACAGCCCCCCAAGTCTGGTTCTGCCCACCCAGCAACCC ACCCCAAAGCCTCTGCAGCAGCCAGGGCTGCCCTCTCAGGCCTGCTCAGTGCAGCCCTCA GGGGGCCAGCCCCCAGGCAGGCAGCTGCAGTATGGGACACTGTACCCGCCCGGACCCAGT GGGCACGGGCAACAGTCTTACCACCGGTCGATGAGTGACTTCAGCCTGGGGAACCTGGAG CAGTTCAACATGGAGAACCCATCGACCAGCCTGGCGCTGGATCCCCCTGGCTTTTCCGAA GGGCCTGGCTTCTTAGGGGGTGAGGGACCAGTGAGTGGCCCCCAGGACCCTCACGCCCTC AACCACCAGAACGTAACCCACTGTTCCCGCCACGGCTCAGGGCCTAACGTCATCCTCACA GGAGACGCCTCCCCAGGCTTCTCCAAGGAGATTGCAGCGGCCCTGGCCGGAGTGCCGGGC TTCGAGGTGTCAGCAGCTGGGCTGGGGCTGGGGCTGGGGCTGGAGGAGGAGCTGCGCATG GAGCCACTGGGCCTGGAGGGGCTCAGCATGCTGAGTGACCCCTGCGCCCTGCTGCCTGAT CCGGCTGTGGAGGACTCGTTCCGCAGTGACCGGCTGCAGTGA |
| Protein Properties | |
| Number of Residues | 693 |
| Molecular Weight | 72818.0 |
| Theoretical pI | 7.14 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>CREB-regulated transcription coactivator 2 MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLA YTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDPRRMVSPLRR YARHIDSSPYSPAYLSPPPESSWRRTMPWGSFPAEKGQLFRLPSALNRTSSDSALHTSVM NPSPQDTYPSPAAPSVLPSRRGGCLDGETDSKVPAIEENLLDDKHLLKPWDAKKLSSSSS RPRSCEVPGINIFPSPDQPATVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETAYPS LSGGSSTSNLTHTMTHLGISGGLALGPGYDAPGLHSPLSHPSFQSSLSNPNLQASLSSPQ PQLQGSHSHPSLPASSLARHALPTTSLGHPSLSAPALSSSSSSSSASSPVLGAPAYPASA PGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVALDTSKLPTD QRLPPYPYSPPSLVLPTQQPTPKPLQQPGLPSQACSVQPSGGQPPGRQLQYGTLYPPGPS GHGQQSYHRSMSDFSLGNLEQFNMENPSTSLALDPPGFSEGPGFLGGEGPVSGPQDPHAL NHQNVTHCSRHGSGPNVILTGDASPGFSKEIAAALAGVPGFEVSAAGLGLGLGLEEELRM EPLGLEGLSMLSDPCALLPDPAVEDSFRSDRLQ |
| External Links | |
| GenBank ID Protein | AAI23455.1 |
| UniProtKB/Swiss-Prot ID | Q08E26 |
| UniProtKB/Swiss-Prot Entry Name | CRTC2_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | BC123454 |
| GeneCard ID | CRTC2 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |