| Identification |
|---|
| BMDB Protein ID
| BMDBP02011 |
| Secondary Accession Numbers
| None |
| Name
| Chitinase-3-like protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| CHI3L1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cation binding |
| Specific Function
| Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CHI3L1 |
| Gene Sequence
|
>1176 bp
ATGCCCTCCTCTGCTGCAGCCAGGATGGGGCTGAGGGCGGCTCATACAGGTTTTGTGGTC
CTGGTGCTGCTCCAGAGCTGTGCTGCATACAAGCTGATCTGCTACTACACCAGCTGGTCC
CAGTACCGGGAGGGTGATGGGAGCTGCTTCCCAGACGCCATCGACCCCTTCCTGTGCACC
CATGTCATCTACAGCTTTGCCAACATAAGCAACAATGAGATCGACACCTGGGAGTGGAAT
GACGTGACGCTCTATGACACACTGAACACACTCAAGAACAGGAACCCCAACCTGAAGACC
CTCCTATCTGTTGGAGGATGGAACTTCGGTTCTCAAAGATTTTCCAAGATAGCTTCCAAG
ACCCAGAGTCGCAGGACTTTCATCAAGTCGGTGCCACCATTTCTGCGGACCCATGGCTTT
GATGGACTGGACCTAGCATGGCTCTACCCCGGGTGGAGAGACAAGCGGCATCTCACCACT
CTGGTCAAGGAAATGAAGGCTGAGTTTGTAAGGGAAGCCCAAGCAGGCACAGAGCAGCTC
CTGCTCAGCGCAGCAGTGCCTGCAGGGAAGATTGCTATTGACAGAGGCTATGACATCGCC
CAGATATCCCGACACCTGGACTTCATCAGCCTTTTGACCTATGACTTTCACGGAGCCTGG
CGCCAGACAGTCGGACATCACAGCCCCCTGTTTCGAGGCCAGGAAGATGCAAGTTCTGAC
AGATTCAGTAACGCTGACTACGCTGTGAGCTACATGCTGAGGCTGGGGGCTCCAGCCAAT
AAGCTGGTGATGGGTATCCCCACTTTTGGGAGGAGCTACACTCTGGCCTCTTCCAAGACA
GATGTGGGAGCCCCCATCTCAGGGCCAGGAATTCCAGGCCAGTTCACCAAGGAGAAAGGG
ATCCTTGCCTATTATGAGATCTGTGACTTCCTCCACGGAGCCATCACCCACAGATTCCGT
GACCAGCAGGTCCCCTATGCCACCAAGGGCAACCAGTGGGTGGCGTATGACGACCAGGAG
AGTGTCAAAAACAAGGCACGGTACCTGAAGAACAGGCAGCTGGCTGGCGCCATGGTGTGG
GCCCTGGACTTGGATGACTTCCGGGGCACCTTCTGTGGGCAGAACCTGGCCTTTCCTCTC
ACAAGTGCCATCAAAGATGTGCTTGCTGAGGTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 383 |
| Molecular Weight
| 43032.0 |
| Theoretical pI
| 8.87 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Chitinase-3-like protein 1
MGLRAAHTGFVVLVLLQSCAAYKLICYYTSWSQYREGDGSCFPDAIDPFLCTHVIYSFAN
ISNNEIDTWEWNDVTLYDTLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASKTQSRRTFI
KSVPPFLRTHGFDGLDLAWLYPGWRDKRHLTTLVKEMKAEFVREAQAGTEQLLLSAAVPA
GKIAIDRGYDIAQISRHLDFISLLTYDFHGAWRQTVGHHSPLFRGQEDASSDRFSNADYA
VSYMLRLGAPANKLVMGIPTFGRSYTLASSKTDVGAPISGPGIPGQFTKEKGILAYYEIC
DFLHGATTHRFRDQQVPYATKGNQWVAYDDQESVKNKARYLKNRQLAGAMVWALDLDDFR
GTFCGQNLTFPLTSAIKDVLARV
|
| External Links |
|---|
| GenBank ID Protein
| AAX46682.1 |
| UniProtKB/Swiss-Prot ID
| P30922 |
| UniProtKB/Swiss-Prot Entry Name
| CH3L1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT021835 |
| GeneCard ID
| CHI3L1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
