| Identification |
|---|
| BMDB Protein ID
| BMDBP02015 |
| Secondary Accession Numbers
| None |
| Name
| Pulmonary surfactant-associated protein A |
| Synonyms
|
Not Available
|
| Gene Name
| SFTPA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| SFTPA1 |
| Gene Sequence
|
>747 bp
ATGCTGCTGTGCTCTTTGACCCTTACCCTCCTCTGGATGGTGGCTTCTGGCCTCGAGTGC
GATGTCAAGGAAGTTTGTCTTGGAAGCCCTGGCATTCCTGGCACTCCTGGATCCCATGGC
CTGCCAGGAAGAGATGGGAGAGATGGTATCAAAGGAGACCCTGGGCCTCCAGGCCCCATG
GGCCCCCCTGGAGGAATGCCAGGCCTCCCTGGGCGTGATGGGATGACTGGAGCCCCTGGC
CTCCCTGGAGAGCGTGGAGAAAAGGGAGAGCCTGGCGAGAGAGGTCCTCCAGGGTTTCCA
GCATATCTAGATGAAGAGCTCCAGGGCACACTCCATGAGATCAGACATCAAGTCCTGCAG
TCACAGGGCGTCCTCCGTTTGCAGGGGTCCGTGCTGGCGGTGGGAGAGAAGGTCTTCTCT
ACCAATGGGCAGTCAGTCAATTTTGATGCCATTAAAGAGTTATGTGCCAGAGTAGGTGGA
CATATTGCTGCCCCGAGGAGTCCAGAGGAGAATGAAGCCATTGTGAGCATCGTGAAGAAG
TACAACACTTATGCTTACCTGGGCCTGGTCGAAGGCCCCACCGCTGGAGACTTCTATTAC
CTGGATGGAGCCCCTGTGAATTATACCAATTGGTACCCAGGGGAGCCCAGGGGCCGGGGT
AAAGAGAAGTGTGTAGAAATATACACAGATGGTCAGTGGAATGACAAGAACTGCCTGCAG
TACCGACTGGCCATCTGTGAGTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 248 |
| Molecular Weight
| 26381.0 |
| Theoretical pI
| 4.84 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pulmonary surfactant-associated protein A
MLLCSLTLTLLWMVASGLECDVKEVCLGSPGIPGTPGSHGLPGRDGRDGIKGDPGPPGPM
GPPGGMPGLPGRDGMTGAPGLPGERGEKGEPGERGPPGFPAYLDEELQGTLHEIRHQVLQ
SQGVLRLQGSVLAVGEKVFSTNGQSVNFDAIKELCARVGGHIAAPRSPEENEAIVSIVKK
YNTYAYLGLVEGPTAGDFYYLDGAPVNYTNWYPGEPRGRGKEKCVEIYTDGQWNDKNCLQ
YRLAICEF
|
| External Links |
|---|
| GenBank ID Protein
| AAI23547.1 |
| UniProtKB/Swiss-Prot ID
| Q6RXL1 |
| UniProtKB/Swiss-Prot Entry Name
| SFTPA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123546 |
| GeneCard ID
| SFTPA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
