| Identification |
|---|
| BMDB Protein ID
| BMDBP02016 |
| Secondary Accession Numbers
| |
| Name
| C-type lectin domain family 6 member A |
| Synonyms
|
Not Available
|
| Gene Name
| CLEC6A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sugar binding |
| Specific Function
| Binds high-mannose carbohydrates in a Ca(2+)-dependent manner (By similarity). Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| CLEC6A |
| Gene Sequence
|
>621 bp
ATGGTGCGGGAAGGGAATGCAGAATCCTGCTTCCGGATGAGGCTCTGGTGTATTGCAGTA
CTTGGCTTAGCCCTCCTCAGTGCATGTTTCATTGTGAGCTGTGTGGTGACTTATTATTTT
ACACATGGCAACACTGGCAAGAGGCTGTCTGAACTGCACACACACCATTCAAATCTAACC
TGCTTCAGTGAAGGGACAAGGGTGACAGAAAAGATTTGGGGATGTTGCCCAGGTACCTGG
AAGCCGTTTGGTTCCAGCTGCTACTTTATTTCTTCTGAAGAGAATTTCTGGGCTAAGAGT
GAGCAGAACTGCATTGGGATGGGAGCTCACTTGGTGGTGATCAACACAGAAACAGAGCAG
GATTTCATTATCCAGCAGCTGAATAAAACATTTTCTTATTTTCTGGGACTCTCAGACCCA
CAAGGGAATGGCAACTGGCAATGGATTGATCAGACACCTTACAAGGAAAATGTCAGATTT
TGGCACCAAAATGAACCCAACTTTTCTGCAGAGGAATGTGCTTCAGTTGTTTTCTGGGAT
GGGAGAGGATGGGGCTGGAATGATGTTTTCTGTGATTCTAAAAGGAAATCAATATGTGAG
ATGAAGAAGATTTACCTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 206 |
| Molecular Weight
| 23738.0 |
| Theoretical pI
| 6.49 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dectin-2 alpha isoform
MVREGNAESCFRMRLWCIAVLGLALLSACFIVSCVVTYYFTHGNTGKRLSELHTHHSNLT
CFSEGTRVTEKIWGCCPGTWKPFGSSCYFISSEENFWAKSEQNCIGMGAHLVVINTETEQ
DFIIQQLNKTFSYFLGLSDPQGNGNWQWIDQTPYKENVRFWHQNEPNFSAEECASVVFWD
GRGWGWNDVFCDSKRKSICEMKKIYL
|
| External Links |
|---|
| GenBank ID Protein
| ABA08411.1 |
| UniProtKB/Swiss-Prot ID
| Q3LUH2 |
| UniProtKB/Swiss-Prot Entry Name
| CLC6A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ176046 |
| GeneCard ID
| CLEC6A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
