Showing Protein Calreticulin (BMDBP02020)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02020 |
| Secondary Accession Numbers | None |
| Name | Calreticulin |
| Synonyms | Not Available |
| Gene Name | CALR |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in calcium ion binding |
| Specific Function | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | CALR |
| Gene Sequence |
>1266 bp ATGTGTCTCAATCATTTTTTGCTTTCCTTAGTACTTTCAATTGTACTTCTATTTCATTTT GTCTTTTATATCTGTCTCCACCATATTGTAACCTTCTTGAGGGAGGAAACAGTTTTCTTT TCTGAACAGTTTCTTACCCTAGATCTGAAGTATAAAGCTTCCAAATTGAGCTCAATTAGA GAAGCCCTTAGCATGTCCAAAGTGGGAATAATAGAGAACTTCTGTTTTTCTGAAATTTCT TTTTTACAGGAATCTATAAAATCCCATGGACGGAGGACGCTGGTAGGCTGCAGTCCATGG GGTCATGAAGAGCAGAACATCGACTGTGGGGGCGGCTATGTGAACGTGTTTCCAGCTGGT TTGGATCAGACAGACATGCACGGAGACTCCGAATACAACATAATGTTTGGCCCGGACATC TGTGGCCCTGGCACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAATGTGCTG ATCAACAAGGATATCCGGTGTAAGGATGATGAATTCACCCACCTGTACACGCTGATTGTG CGGCCTAATAATACCTATGAGGTGAAGATTGACAACAGCCAGGTGGAGTCAGGCTCCTTG GAGGACGATTGGGATTTCTTGCCACCCAAGAAGATAAAGGATCCTGATGCCGCTAAGCCT GAAGACTGGGACGATCGCGCCAAGATCGATGACCCTACAGACTCCAAGCCTGAGGATTGG GACAAGCCTGAGCACATTCCTGACCCTGATGCTAAGAAACCTGAGGACTGGGATGAAGAG ATGGACGGAGAGTGGGAACCACCTCTTATTCAGAACCCAGAGTACAAGGGGGAGTGGAAA CCCAGGCAGATCGACAACCCAGAGTACAAGGGCATTTGGATCCATCCAGAGATTGACAAC CCTGAGTATTCCCCTGACAGCAACATCTATGCCTATGAAAACTTCGCTGTTCTAGGCTTG GATCTTTGGCAGGTCAAGTCTGGCACCATCTTTGACAACTTCCTCATCACCAACGATGAA GCGTATGCTGAGGAGTTTGGCAACGAGACGTGGGGTGTTACAAAGGCAGCAGAAAAGCAA ATGAAGGACAAGCAAGATGAAGAGCAGAGGCTACATGAGGAGGAGGAGGAGAAGAAAGGC AAGGAGGAGGAAGAGGCAGAGAAAGATGATGACGAAGACAAGGATGAGGATGAGGAGGAT GAAGATGAGAAGGAAGAGGAGGAGGAAGAAGATGCTGCCGCTGCGCAGGCCAAGGATGAG CTGTAG |
| Protein Properties | |
| Number of Residues | 417 |
| Molecular Weight | 48039.0 |
| Theoretical pI | 4.06 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Calreticulin MLLPVPLLLGLLGLAAADPTVYFKEQFLDGDGWTERWIESKHKPDFGKFVLSSGKFYGDQ EKDKGLQTSQDARFYALSARFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPAGLDQT DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPNN TYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDDRAKIDDPTDSKPEDWDKPE HIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPEYKGIWIHPEIDNPEYS PDSNIYAYENFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK QDEEQRLHEEEEEKKGKEEEEADKDDDEDKDEDEEDEDEKEEEEEEDAAAGQAKDEL |
| External Links | |
| GenBank ID Protein | AAC37307.1 |
| UniProtKB/Swiss-Prot ID | P52193 |
| UniProtKB/Swiss-Prot Entry Name | CALR_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | L13462 |
| GeneCard ID | CALR |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |