| Identification |
|---|
| BMDB Protein ID
| BMDBP02025 |
| Secondary Accession Numbers
| None |
| Name
| Solute carrier family 2, facilitated glucose transporter member 4 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC2A4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| SLC2A4 |
| Gene Sequence
|
>1530 bp
ATGCCGTCGGGCTTCCAACAGATCGGCTCTGAAGATGGGGAGCCCCCTCGGCAGCGAGTC
ACTGGGACCTTGGTCCTTGGCGTATTCTCCGCTGTTCTTGGCTCCCTGCAGTTTGGCTAC
AACATTGGGGTCATCAATGCCCCCCAGAAGGTGATTGAACAGAGCTACAATGAGACCTGG
CTGGGGAGGCAGGGGCCTGAGGGACCCGGCTCCATCCCACCAGGCACACTTACCACACTC
TGGGCTCTCTCCGTGGCCATCTTCTCTGTGGGTGGCATGATCTCATCCTTCCTGATTGGC
ATCATCTCTCAGTGGCTGGGAAGGAAGAGGGCCATGCTGTTCAGCAACGCCCTGGCAGTG
CTGGGGGGCACCCTCATGGGCCTGGCCAAGGCAGCTGCCTCCTATGAGATGCTCATTCTT
GGACGGTTCTTCATTGGAGCCTACTCAGGACTGACGTCGGGACTGGTACCCATGTACGTG
GGGGAGATTGCCCCTACTCACCTGCGGGGCGCCCTGGGGACACTCAATCAACTAGCCATC
GTCACTGGCATCCTAATCGCCCAGGTGCTAGGTTTGGAGTCCATGCTGGGCACAGCCACC
TTATGGCCACTCCTCCTGGGCATCACCGTGCTGCCTGCCCTCCTGCAGATGGTCCTGCTG
CCCCTCTGCCCGGAAAGCCCCCGCTACCTCTACATCATCCGGAACCTGGAGGGGCCCGCC
AGAAAGAGTCTGAAGCGCCTGACGGGGTGGGCCGACGTGTCTGAGGTGTTGGCTGAGCTG
AAGGAGGAGAAGCGGAAGCTGGAGCGTGAGCGGTCCCTGTCCTTGCTCCAGCTCCTGGGC
AGCCACACCCATCGGCAGCCCCTCGTCATCGCCATTGTGCTGCAGCTGAGCCAGCAGCTC
TCAGGCATCAATGCGGTTTTCTATTATTCCACCAGCATCTTTGAGTCAGCGGGGGTAGAG
AAACCAGCCTATGCCACCATTGGAGCCGGCGTGGTCAACACAGTCTTCACCTTAGTCTCG
GTGTTCTTGGTGGAACGGGCTGGGCACCGGACCCTCCATCTCCTGGGCCTGGCAGGCATG
TGTGCCTGCGCCATCTTGATGACTGTGGCTCTGCTTCTGCTGGAGCGGGTTCCAGCCATG
AGCTATGTCTCCATTGTGGCCATCTTTGGCTTCGTGGCCTTCTTTGAAATTGGCCCTGGC
CCCATCCCCTGTTTCATCGTGGCCGAGCTCTTCAGCCAGGGGCCCCGCCCAGCGGCCATG
GCAGTGGCTGGGTTCTCCAACTGGACATGCAACTTCATCATCGGCATGGGTTTCCAGTAT
GTGGCGGATGCTATGGGTCCCTACGTCTTTCTTCTATTCGCGGTCCTCCTGCTTGGCTTC
TTCATCTTCACCTTCTTAAAAGTGCCTGAAACCCGAGGCAGGACGTTTGACCAGATCTCA
GCCGTTTTCCACCGGACACCTTCTCTTCTGGAGCAGGAAGTGAAACCCAGCACAGAACTG
GAGTACTTAGGGCCAGATGAGCATGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 509 |
| Molecular Weight
| 55084.0 |
| Theoretical pI
| 7.54 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 25-45
- 82-102
- 112-132
- 143-163
- 172-192
- 201-221
- 288-308
- 324-344
- 354-374
- 385-405
- 418-438
- 446-466
|
| Protein Sequence
|
>Solute carrier family 2, facilitated glucose transporter member 4
MPSGFQQIGSEDGEPPRQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETW
LGRQGPEGPGSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLFNNALAV
LGGTLMGLAKAAASYEMLILGRFFIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI
VTGILIAQVLGLESMLGTATLWPLLLGITVLPALLQMVLLPLCPESPRYLYIIRNLEGPA
RKSLKRLTGWADVSEVLAELKEEKRKLERERPLSLLQLLGSHTHRQPLVIAIVLQLSQQL
SGINAVFYYSTSIFESAGVEKPAYATIGAGVVNTVFTLVSVFLVERAGRRTLHLLGLAGM
CGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM
AVAGFSNWTCNFIIGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQIS
AVFHRTPSLLEQEVKPSTELEYLGPDEHD
|
| External Links |
|---|
| GenBank ID Protein
| BAA21105.1 |
| UniProtKB/Swiss-Prot ID
| Q27994 |
| UniProtKB/Swiss-Prot Entry Name
| GLUT4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D63150 |
| GeneCard ID
| SLC2A4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
