| Identification |
|---|
| BMDB Protein ID
| BMDBP02050 |
| Secondary Accession Numbers
| None |
| Name
| Adhesion G protein-coupled receptor L1 |
| Synonyms
|
Not Available
|
| Gene Name
| ADGRL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor activity |
| Specific Function
| Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| ADGRL1 |
| Gene Sequence
|
>4404 bp
ATGGCCCGCCTGGCCGCCGTGCTCTGGAGTCTCTGCGTCACAGCCATCCTCGTCACCTCA
GCCACCCAAGGCCTGAGCCGGGCTGGGCTCCCATTTGGGCTGATGCGCCGGGAGCTGGCA
TGTGAAGGCTACCCCATCGAGCTGCGGTGCCCGGGCAGCGACGTTATCATGGTGGAGAAT
GCCAACTATGGGCGCACAGATGACAAGATCTGCGACGCCGACCCTTTCCAGATGGAGAAC
GTGCAGTGCTACCTGCCGGATGCCTTCAAGATCATGTCCCAGAGGTGTAACAACCGCACC
CAGTGTGTGGTGGTCGCTGGCTCCGACGCCTTTCCGGACCCCTGCCCTGGGACCTACAAG
TACCTGGAGGTGCAGTACGACTGTGTCCCCTACATCTTCGTGTGCCCAGGGACCCTGCAG
AAGGTGCTGGAGCCCACCTCAACCCACGAGTCGGAGCACCAGTCTGGTGCATGGTGCAAG
GACCCGCTGCAGGCAGGTGACCGCATCTACGTCATGCCGTGGATCCCCTACCGCACGGAC
ACGCTGACCGAGTACGCCTCGTGGGAGGACTACGTGGCAGCGCGCCACACCACCACCTAT
CGCCTGCCCAACCGCGTAGACGGCACGGGCTTCGTGGTCTACGACGGCGCCGTCTTCTAC
AACAAGGAGCGCACGCGCAACATCGTCAAGTACGACTTGCGCACGCGCATCAAGAGCGGG
GAGACGGTYATCAACACAGCCAATTACCACGACACCTCGCCCTACCGCTGGGGGGGCAAG
ACCGACATCGACCTGGCAGTGGATGAGAACGGGCTGTGGGTCATCTATGCTACTGAGGGC
AACAACGGGCGGCTGGTGGTGAGCCAACTCAACCCCTACACGCTGCGCTTCGAGGGCACG
TGGGAGACCGGCTACGACAAGCGCTCCGCGTCCAACGCCTTCATGGTGTGCGGCGTCCTG
TACGTGCTGCGCTCCGTGTACGTGGACGACGACAGCGAGGCAGCCGGCAACCGCGTGGAC
TACGCCTTCAACACCAACGCCAACCGTGAGGAGCCTGTGAGCCTGGCCTTTCCCAACCCC
TACCAGTTCGTCTCCTCTGTCGACTATAACCCTCGCGACAACCAGCTCTATGTCTGGAAC
AACTACTTTGTGGTGCGCTATAGCCTGGAGTTTGGGCCGCCCGACCCTAGTGCGGGCCCA
GCCACTTCCCCACCCCTCAGCACAACCACCACAGCCCGGCCCACACCCCTGACGAGCACA
GCCTCGCCAGCAGCCACCACCCCGCTCCGCCGAGCACCCCTCACCACGCACCCCGTGGGT
GCCATCAACCAGCTGGGACCTGACCTACCTCCAGCCACTGCCCCGGCCCCCAGCACCCGG
CGGCCCCCTGCCCCCAATCTGCACGTGTCCCCAGAACTCTTTTGTGAACCTCGAGAGGTG
CGGCGGGTCCAATGGCCGGCCACCCAGCAGGGCATGCTGGTGGAGAGGCCCTGCCCCAAG
GGGACTCGAGGAATTGCCTCCTTCCAGTGTCTACCAGCCCTGGGGCTCTGGAATCCCCGG
GGCCCTGACCTCAGCAACTGCACCTCCCCCTGGGTCAACCAGGTGGCCCAGAAGATCAAG
AGTGGGGAGAACGCAGCCAACATTGCCAGCGAGCTGGCCCGCCACACCCGGGGCTCCATC
TATGCGGGTGATGTGTCCTCCTCTGTGAAGCTGATGGAGCAATTGCTGGACATTCTGGAT
GCCCAGCTGCAGGCGCTGCGGCCCATTGAGCGCGAGTCGGCCGGCAAGAACTACAACAAG
ATGCACAAGCGGGAGAGAACTTGCAAGGACTACATCAAGGCTGTGGTGGAGACAGTGGAC
AACCTGCTGCGGCCGGAGGCCCTCGAGTCCTGGAAAGACATGAACGCCACCGAGCAGGCG
CACACGGCCACCATGCTGCTAGACGTCCTGGAAGAGGGCGCCTTCCTACTGGCAGACAAT
GTCAGGGAGCCGGCCCGCTTCCTGGCCGCCAAGCAGAACGTGGTCCTCGAGGTCACAGTC
CTGAACACTGAGGGCCAAGTGCAGGAGCTGGTGTTCCCCCAGGAGTACCCGAGCGAGAAC
TCAATCCAGCTGTCTGCCAACACCATCAAGCAGAACAGCCGCAACGGAGTGGTCAAGGTT
GTCTTCATTCTCTACAACAACCTGGGCCTCTTCCTGTCCACCGAGAACGCCACGGTGAAG
CTGGCGGGTGAAGCAGGCTCGGGGGGCCCAGGGGGCGCCTCCCTGGTGGTGAACTCGCAG
GTCATCGCAGCGTCCATCAACAAGGAGTCCAGCCGAGTCTTCCTGATGGACCCTGTCATC
TTCACTGTGGCCCACCTGGAGGCCAAGAACCACTTCAACGCTAACTGCTCCTTCTGGAAC
TACTCAGAGCGCTCCATGCTGGGCTACTGGTCAACCCAGGGCTGCCGCCTGGTGGAGTCC
AATAAGACCCATACCACATGTGCCTGCAGCCACCTCACCAACTTTGCTGTGCTCATGGCG
CATCGCGAGATCTACCAGGGCCGCATCAATGAGCTGCTGCTGTCGGTCATCACTTGGGTG
GGCATTGTCATCTCCCTGGTCTGCCTGGCCATCTGTATCTCCACCTTCTGCTTCCTGCGG
GGGCTACAGACCGACCGGAACACCATCCACAAGAACCTCTGCATCAACCTCTTCTTGGCG
GAGCTGCTCTTCCTTGTCGGGATAGACAAGACTCAGTATGAGATCGCCTGCCCCATCTTC
GCGGGCTTGCTGCACTATTTCTTCCTGGCCGCCTTCTCCTGGCTGTGCCTGGAGGGTGTG
CATCTCTACCTGCTGCTGGTGGAGGTGTTTGAGAGCGAGTACTCCCGCACCAAGTACTAC
TACCTGGGCGGGTACTGCTTCCCTGCCCTGGTGGTGGGCATTGCGGCCGCCATCGACTAC
CGCAGCTATGGCACCGAGAAGGCGTGTTGGCTCCGAGTGGACAATTACTTCATCTGGAGC
TTCATTGGGCCCGTCTCCTTTGTTATTGTGGTGAACCTGGTGTTCCTCATGGTGACTCTG
CACAAGATGGTCCGGAGCTCATCCGTGCTCAAGCCTGACTCCAGTCGCCTCGACAACATT
AAATCCTGGGCCCTGGGAGCCATTGCGCTGCTCTTCCTGCTGGGCCTCACGTGGGCTTTC
GGCCTCCTCTTTATCAACAAGGAGTCCGTGGTCATGGCCTATCTCTTCACCACCTTCAAC
GCCTTCCAGGGGGTCTTCATCTTTGTCTTTCACTGCGCCTTACAGAAGAAGGTGCATAAG
GAGTACAGCAAGTGCCTGCGGCACTCCTACTGCTGCATCCGCTCCCCACCCGGGGGTGCG
CACGGCTCACTCAAGACCTCAGCCATGCGGAGCAATGCCCGCTACTACACAGGGACCCAG
AGCCGAATCCGGAGGATGTGGAACGACACCGTGAGGAAGCAGACGGAATCCTCCTTCATG
GCGGGCGACATCAACAGCACCCCTACCCTGAACCGAGGTACCATGGGGAACCACCTGCTG
ACCAACCCTGTGCTGCAGCCCCGTGGGGGCACCAGCCCCTACAACACCCTCATTGCTGAG
TCAGTGGGCTTCAACCCCTCCTCGCCCCCAGTCTTCAACTCCCCAGGGAGCTACCGGGAA
CCCAAGCACCCCTTGGGAGGCCGGGAAGCCTGCGGCATGGACACGCTACCCCTCAACGGC
AACTTCAACAACAGCTACTCCTTGCGAAGCGGGGATTTCCCTCCTGGGGACGGGGCCCCT
GAGCCCCCTCGAGGCCGGAACCTGGCCGACGCCGCTGCCTTCGAGAAGATGATCATCTCG
GAGCTGGTGCACAACAACCTGCGCGGGGGCAGCAGCGGAGCCAAGGGTCCTCCACCGCCG
GAGCCCCCTGTGCCTCCAGTGCCAGGGGGCAGCGGGGAGGAAGAGGCTGGCGGGCCCGGG
GCTGACCGGGCAGAGATCGAACTTCTCTACAAGGCCCTGGAGGAGCCACTGCTGCTGCCC
CGGGCCCAGTCGGTGCTGTACCAGAGCGATCTGGACGAGTCGGAGAGCTGCACGGCGGAG
GATGGAGCCACCAGCCGGCCCCTCTCCTCGCCTCCAGGCCGGGACTCCCTCTACGCCAGC
GGGGCCAACCTGCGGGACTCGCCCTCCTACCCGGACAGCAGCCCCGAGGGGCCCAGTGAG
GCCCTGCCCCCACCCCCACCCGCACCCCCTGGCCCCCCCGAAATCTACTACACCTCGCGC
CCGCCAGCCCTGGTGGCCCGGAACCCCCTGCAGGGCTACTACCAGGTCCGGCGGCCCAGC
CACGAGGGCTACCTGGCGGCCCCGGGCCTTGAAGGGCCAGGGCCCGACGGGGATGGGCAG
ATGCAACTGGTTACCAGTCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1472 |
| Molecular Weight
| 162205.0 |
| Theoretical pI
| 6.63 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 858-878
- 893-913
- 920-940
- 964-984
- 1002-1022
- 1050-1070
- 1075-1095
|
| Protein Sequence
|
>Latrophilin-1
MARLAAVLWSLCVTAILVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVEN
ANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYK
YLEVQYDCVPYKVKQKVFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWI
PYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRT
RIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTL
RFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSL
AFPNPYQFVSSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPT
PLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPAPSTRRPPAPNLHVSPELFC
EPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQV
AQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAG
KNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQAHTATMLLDVLEEGAF
LLADNVREPARFLAAKQNVVLEVTVLNTEGQVQELVFPQEYPSENSIQLSANTIKQNSRN
GVVKVVFILYNNLGLFLSTENATVKLAGEAGSGGPGGASLVVNSQVIAASINKESSRVFL
MDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNF
AVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCI
NLFLAELLFLVGIDKTQYEIACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYS
RTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVF
LMVTLHKMVRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYL
FTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGAHGSLKTSAMRSNARY
YTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYN
TLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPP
GDGAPEPPRGRNLADAAAFEKMIISELVHNNLRGGSSGAKGPPPPEPPVPPVPGGSGEEE
AGGPGADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRD
SLYASGANLRDSPSYPDSSPEGPSEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQ
VRRPSHEGYLAAPGLEGPGPDGDGQMQLVTSL
|
| External Links |
|---|
| GenBank ID Protein
| AAD09191.1 |
| UniProtKB/Swiss-Prot ID
| O97831 |
| UniProtKB/Swiss-Prot Entry Name
| AGRL1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF111097 |
| GeneCard ID
| ADGRL1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
