| Identification |
|---|
| BMDB Protein ID
| BMDBP02060 |
| Secondary Accession Numbers
| None |
| Name
| Aggrecan core protein |
| Synonyms
|
Not Available
|
| Gene Name
| ACAN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| ACAN |
| Gene Sequence
|
>6984 bp
ATGACCACTTTACTCTTGGTGTTTGTGACTCTGAGGGTCATCACAGCAGCCATCTCAGTA
GAAGTTTCAGAACCTGACAACTCGCTGAGTGTCAGCATCCCTGAACCGTCCCCACTTCGG
GTCCTCCTGGGGAGCTCCCTCACCATCCCCTGCTACTTCATCGACCCCATGCACCCCGTG
ACCACCGCCCCCTCCACCGCCCCCCTTGCCCCAAGAATCAAGTGGAGCCGCATTTCCAAG
GAGAAGGAGGTGGTGCTGCTGGTGGCCACTGAAGGGCGGGTGCGGGTCAACAGCGCCTAC
CAAGACAAGGTCACGCTGCCCAACTACCCCGCCATCCCCAGCGACGCCACCCTGGAAATC
CAGAACATGCGCTCCAATGACTCCGGGATTCTACGCTGCGAGGTGATGCACGGCATCGAG
GACAGCCAGGCCACCCTAGAGGTCGTGGTAAAAGGCATCGTGTTCCATTACAGAGCCATC
TCCACGCGCTACACCCTGGACTTTGACAGGGCGCAGCGGGCCTGCCTGCAGAACAGCGCC
ATCATCGCCACGCCCGAGCAGCTGCAGGCTGCCTATGAGGACGGCTTCCACCAGTGCGAC
GCCGGCTGGCTGGCCGATCAGACTGTGAGGTATCCCATCCACACGCCGAGGGAAGGTTGC
TATGGAGACAAGGACGAGTTTCCCGGCGTGAGAACCTACGGCATCCGGGACACCAACGAA
ACCTATGACGTGTACTGCTTCGCGGAGGAGATGGAGGGCGAGGTCTTCTATGCAACATCC
CCGGAGAAGTTCACCTTCCAAGAGGCAGCCAACGAGTGCCGGCGGCTGGGCGCCCGGCTG
GCCACCACGGGCCAACTCTACCTGGCCTGGCAGGGTGGCATGGACATGTGCAGCGCCGGC
TGGCTGGCTGACCGCAGCGTGCGATACCCCATCTCCAAGGCCCGGCCTAACTGCGGGGGC
AACCTCCTGGGAGTGAGGACCGTCTACCTGCACGCCAACCAGACGGGCTACCCTGACCCT
TCATCCCGCTATGACGCCATCTGCTACACAGGTGAAGACTTTGTGGACATCCCAGAAAGC
TTTTTCGGGGTGGGCGGTGAGGAGGACATCACCATCCAGACGGTGACCTGGCCTGACGTG
GAGCTGCCCCTGCCCCGAAATATCACTGAGGGTGAAGCCCGAGGCAGCGTGATCCTCACG
GCAAAGCCCGACTTTGAAGTCTCCCCCACCGCCCCGGAACCCGAGGAGCCTTTCACGTTT
GTCCCTGAAGTAAGGGCCACTGCATTCCCCGAAGTAGAGAACAGGACTGAAGAGGCCACC
CGGCCCTGGGCCTTTCCCAGAGAGTCCACCCCCGGCCTGGGAGCCCCCACGGCCTTCACC
AGCGAGGACCTCGTCGTGCAGGTGACCTTAGCCCCAGGTGCGGCTGAGGTCCCTGGGCAG
CCACGACTGCCAGGGGGAGTCGTGTTCCACTACCGCCCGGGCTCCTCCCGCTACTCGCTG
ACCTTTGAGGAGGCCAAGCAGGCCTGCCTGCGCACCGGGGCCATCATCGCCTCGCCCGAG
CAGCTCCAGGCCGCCTATGAAGCAGGCTACGAGCAGTGTGACGCCGGCTGGCTGCAGGAC
CAGACAGTCAGATACCCCATTGTGAGCCCGCGGACCCCCTGTGTGGGTGACAAGGACAGC
AGCCCGGGGGTCCGGACCTACGGCGTGCGGCCACCATCAGAAACCTACGATGTCTACTGC
TACGTGGACAGACTCGAGGGGGAGGTGTTCTTCGCCACACGCCTGGAGCAGTTCACCTTC
TGGGAAGCCCAGGAGTTCTGTGAATCCCAAAACGCCACTCTGGCCACCACAGGCCAGCTC
TATGCTGCCTGGAGCCGTGGTCTGGACAAGTGCTACGCCGGCTGGCTGGCTGACGGCAGC
CTCCGCTACCCCATCGTCACCCCAAGGCCCGCCTGTGGCGGGGACAAACCGGGCGTGAGA
ACCGTCTACCTCTACCCCAACCAGACGGGCCTCCTGGATCCGCTGTCCCGGCACCACGCC
TTCTGCTTCCGAGGTGTTTCAGCGGCGCCCTCTCCAGAAGAAGAGGAGGGTAGTGCACCC
ACAGCAGGCCCTGACGTGGAGGAGTGGATGGTGACACAAGTGGGGCCTGGCGTGGCTGCT
GTCCCCATCGGGGAGGAGACGACTGCAATCCCAGGCTTCACCGTTGAGCCAGAAAACAAG
ACGGAATGGGAACTTGCCTACACCCCAGCGGGCACTTTGCCACTACCAGGGATCCCTCCT
ACATGGCCTCCCACTGGAGAAGCAACAGAGGAGCACACAGAAGGCCCTTCTGCAACGGAA
GTGCCCTCAGCCTCAGAGAAGCCGTTCCCTTCAGAGGAACCATTCCCCCCAGAGGAACCA
TTCCCCTCAGAGAAACCATTCCCCCCAGAGGAACTGTTCCCCTCAGAGAAGCCATTCCCC
TCAGAAAAGCCGTTCCCCTCAGAGGAACCGTTCCCCTCAGAAAAACCATTCCCCCCAGAG
GAACTGTTCCCCTCAGAGAAGCCAATCCCCTCAGAGGAGCCATTCCCCTCAGAGGAGCCA
TTCCCCTCAGAGAAGCCATTCCCCCCAGAGGAACCATTCCCCTCAGAGAAACCAATCCCC
TCAGAGGAGCCTTTCCCCTCAGAGAAGCCATTCCCTTCAGAGGAGCCATTCCCCTCAGAG
GAGCCATCCACACTTTCAGCCCCAGTGCCCAGCAGGACTGAGCTGCCAAGCTCTGGGGAG
GTGTCTGGGGTGCCCGAAATCAGTGGTGACTTCACAGGCAGTGGAGAAATTTCAGGACAC
CTAGACTTCAGTGGGCAGCCCTCAGGGGAAAGTGCAAGTGGACTGCCCTCTGAAGACCTT
GACTCCAGTGGGCTCACCTCTACAGTGGGCTCAGGCCTGCCTGTGGAAAGTGGACTGCCT
TCAGGGGAAGAAGAGAGAATTACATGGACCAGTGCTCCTAAAGTTGACAGGTTGCCCTCT
GGGGGTGAGGGCCCAGAAGTTTCTGGAGTAGAGGATATCAGTGGACTTCCTTCTGGAGGA
GAGGTTCATCTAGAGATCTCTGCCTCTGGAGTAGAGGACATCAGTGGACTTCCTTCTGGA
GGAGAGGTTCATCTAGAGATCTCTGCCTCTGGAGTAGAGGACCTAAGTAGAATTCCTTCT
GGAGAAGGTCCAGAAATCTCTGCCTCTGGAGTAGAGGACATCAGTGGACTTCCTTCTGGA
GAGGAAGGTCATCTAGAGATCTCTGCCTCTGGAGTAGAAGACCTCAGTGGAATTCCTTCT
GGAGAAGGTCCAGAAGTCTCTGCTTCTGGAGTAGAGGACCTTATTGGACTTCCTTCTGGA
GAAGGTCCAGAAGTCTCTGCTTCTGGAGTAGAGGACCTCAGTAGACTTCCTTCTGGAGAA
GGTCCAGAAGTCTCTGCTTCTGGGGTAGAGGACCTTAGTGGACTTCCTTCTGGAGAAGGT
CCAGAAGTCTCTGTTTCTGGAGTAGAGGATCTCAGCAGACTTCCTTCTGGAGAAGGTCCA
GAAGTCTCTGCTTCTGGAGTAGAGGACCTCAGTAGACTTCCTTCTGGAGAAGGTCCAGAA
ATCTCTGTGTCTGGAGTAGAGGACATCAGTATACTTCCTTCTGGAGAAGGTCCAGAAGTC
TCTGCCTCTGGAGTAGAGGACCTCAGTGTTCTTCCTTCTGGAGAAGGTCATCTAGAGATC
TCTACCTCTGGAGTAGAGGACCTCAGTGTTCTTCCTTCTGGTGAAGGTCATCTAGAGACT
TCCTCTGGAGTAGAGGACATCAGTAGACTTCCTTCTGGAGAAGGTCCAGAAGTCTCTGCC
TCTGGAGTAGAGGACCTCAGTGTTCTTCCTTCTGGAGAAGATCATCTAGAGATCTCTGCC
TCTGGAGTAGAGGACCTCGGTGTTCTTCCTTCTGGAGAAGATCATCTAGAGATCTCTGCC
TCTGGAGTAGAGGACATCAGTAGACTTCCTTCTGGAGAAGGTCCAGAAGTCTCTGCCTCT
GGAGTAGAGGACCTCAGTGTTCTTCCTTCTGGAGAAGGTCATCTAGAGATCTCTGCCTCT
GGAGTAGAGGACCTCAGTAGACTTCCTTCTGGAGGAGAGGATCATCTAGAGACTTCTGCT
TCTGGAGTAGGGGACCTTAGTGGACTTCCTTCTGGAAGGGAAGGTCTGGAGATCTCTGCT
TCTGGAGCTGGGGATCTTAGTGGGTTGACTTCTGGAAAAGAAGACTTGACTGGGTCAGCT
TCTGGAGCCTTGGACCTTGGCAGAATACCTTCTGTAACTCTAGGAAGTGGGCAAGCTCCA
GAAGCAAGTGGTCTTCCTTCTGGATTTAGTGGTGAGTATTCTGGGGTGGACCTTGAAAGT
GGCCCATCCTCTGGCCTTCCTGATTTCAGTGGACTTCCATCTGGGTTCCCAACTGTCTCC
CTAGTGGATACTACATTGGTGGAAGTCGTCACAGCCACCACAGCAGGTGAACTAGAAGGA
AGGGGAACCATTGACATCAGCGGTGCTGGAGAAACATCTGGGCTGCCCTTCAGTGAGTTG
GACATTAGTGGAGGAGCAAGCGGACTCTCTTCAGGAGCTGAACTCAGTGGCCAAGCATCT
GGGTCTCCTGACATCAGTGGGGAAACCTCTGGACTCTTTGGTGTCAGTGGACAGCCCTCA
GGGTTTCCTGACATTAGTGGGGAAACTTCCGGGCTTCTTGAGGTCAGTGGGCAGCCATCA
GGGTTTTATGGAGAAATATCTGGCGTGACTGAGCTTAGCGGACTGGCCTCTGGACAACCA
GAAATCAGTGGAGAAGCTTCTGGAATTCTTTCTGGCCTTGGTCCACCATTCGGCATAACC
GACCTGAGCGGAGAAGCACCCGGGATCCCTGATCTCAGTGGGCAACCATCGGGCTTGCCA
GAGTTCAGTGGGACAGCATCCGGGATCCCTGACCTGGTTTCCAGTGCTGTGAGTGGCAGT
GGTGAATCTTCTGGCATTACGTTCGTGGACACCAGTTTGGTTGAAGTGACCCCAACGACA
TTTAAAGAAGAAGAAGGCTTAGGATCTGTGGAACTCAGTGGCCTCCCTTCAGGAGAGCTG
GGTGTCTCAGGCACATCTGGGCTAGCGGATGTCAGTGGACTGTCTTCTGGAGCAATTGAC
TCCAGTGGGTTTACGTCCCAGCCTCCAGAATTCAGTGGCCTGCCAAGCGGAGTAACTGAG
GTCAGTGGAGAAGCCTCCGGAGCTGAAAGTGGGAGCAGCCTGCCCTCCGGAGCATATGAC
AGCAGTGGACTTCCGTCTGGTTTCCCCACTGTCTCTTTTGTAGACAGGACTTTGGTGGAA
TCTGTAACCCAGGCTCCAACTGCTCAAGAAGCAGGAGAAGGGCCTTCAGGCATTCTGGAA
CTTAGCGGTGCGCCTTCTGGAGCACCAGACATGTCTGGAGACCATTTGGGATCTTTGGAC
CAAAGTGGGCTTCAGTCTGGACTAGTGGAGCCCAGTGGGGAGCCCGCAAGTACTCCATAT
TTTAGTGGGGACTTTTCTGGCACCACTGATGTAAGTGGGGAATCCTCTGCAGCCACGAGC
ACCAGTGGGGAGGCCTCCGGACTTCCAGAAGTTACGTTAATCACATCTGAGTTGGTGGAG
GGAGTTACTGAACCAACCGTTTCCCAGGAACTGGGCCAGAGACCCCCCGTAACATACACC
CCCCAGCTTTTTGAATCCAGTGGTGAAGCCTCTGCATCTGGGGATGTGCCAAGGTTCCCT
GGATCGGGGGTAGAAGTGTCATCAGTCCCAGAATCCAGCGGTGAGACGTCAGCCTATCCC
GAGGCTGAGGTGGGAGCATCTGCTGCCCCCGAGGCAAGCGGAGGAGCTTCCGGGTCCCCT
AACCTGAGTGAAACCACCTCCACCTTCCATGAAGCTGATCTGGAGGGAACCTCAGGCCTG
GGAGTGAGTGGCAGCCCCTCAGCCTTTCCAGAAGGCCCCACGGAGGGCTTGGCCACCCCG
GAAGTGAGTGGAGAGTCAACCACTGCCTTTGACGTGAGCGTAGAGGCATCAGGCTCACCT
TCTGCCACTCCCCTGGCTTCTGGAGACAGGACTGACACCAGCGGAGATCTGTCTGGCCAC
ACCTCGGGGCTGGATATTGTCATCAGCACCACCATCCCAGAATCCGAGTGGACTCAGCAG
ACCCAGCGCCCTGCAGAGGCGCGTCTAGAAATCGAATCCTCAAGCCCTGTGCACTCAGGA
GAAGAGAGCCAAACAGCCGACACAGCCACCTCCCCGACTGATGCTTCTATCCCAGCCTCC
GCAGGAGGGACAGATGATTCAGAGGCAACCACAACAGACCAGAAGCTGTGCGAGGAGGGC
TGGACCAAGTTCCAGGGCCACTGTTACCGCCACTTCCCGGACCGGGCAACCTGGGTGGAC
GCTGAGAGCCAGTGCCGGAAGCAGCAGTCACACCTGAGCAGCATCGTCACCCCCGAGGAG
CAGGAGTTTGTCAACAACAATGCCCAGGACTACCAGTGGATCGGCCTGAACGACAAGACC
ATCGAAGGGGACTTCCGCTGGTCAGATGGACACTCCTTGCAATTTGAGAACTGGCGCCCC
AACCAGCCTGACAACTTCTTTGCCACTGGGGAGGACTGTGTGGTGATGATCTGGCATGAG
AAGGGCGAGTGGAACGATGTCCCATGTAATTACCAGCTACCCTTCACCTGTAAAAAGGGC
ACAGTGGCCTGCGGAGAGCCCCCCGTGGTGGAGCATGCCAGAATCTTCGGACAGAAGAAG
GACCGATACGAGATCAATGCCCTGGTGCGGTACCAGTGCACCGAGGGCTTCATCCAGGGC
CATGTGCCCACCATCCGGTGCCAGCCCAGCGGGCACTGGGAGGAGCCTCGGATCACCTGC
ACAGACCCCGCTACCTACAAGCGCAGACTACAGAAGCGGAGCTCACGGCCCCTGAGGAGG
AGCCACCCCAGCACGGCCCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2364 |
| Molecular Weight
| 246362.0 |
| Theoretical pI
| 3.88 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 20-40
- 53-73
- 86-106
- 126-146
- 166-186
- 231-251
- 262-282
|
| Protein Sequence
|
>Aggrecan core protein
MTTLLLVFVTLRVITAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPV
TTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEI
QNMRSNDSGILRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSA
IIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNE
TYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAG
WLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPES
FFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGSVILTAKPDFEVSPTAPEPEEPFTF
VPEVRATAFPEVENRTEEATRPWAFPRESTPGLGAPTAFTSEDLVVQVTLAPGAAEVPGQ
PRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAIIASPEQLQAAYEAGYEQCDAGWLQD
QTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTF
WEAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVR
TVYLYPNQTGLLDPLSRHHAFCFRGVSAAPSPEEEEGSAPTAGPDVEEWMVTQVGPGVAA
VPIGEETTAIPGFTVEPENKTEWELAYTPAGTLPLPGIPPTWPPTGEATEEHTEGPSATE
VPSASEKPFPSEEPFPPEEPFPSEKPFPPEELFPSEKPFPSEKPFPSEEPFPSEKPFPPE
ELFPSEKPIPSEEPFPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFPSEKPFPSEEPFPSE
EPSTLSAPVPSRTELPSSGEVSGVPEISGDFTGSGEISGHLDFSGQPSGESASGLPSEDL
DSSGLTSTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEVSGVEDISGLPSGG
EVHLEISASGVEDISGLPSGGEVHLEISASGVEDLSRIPSGEGPEISASGVEDISGLPSG
EEGHLEISASGVEDLSGIPSGEGPEVSASGVEDLIGLPSGEGPEVSASGVEDLSRLPSGE
GPEVSASGVEDLSGLPSGEGPEVSVSGVEDLSRLPSGEGPEVSASGVEDLSRLPSGEGPE
ISVSGVEDISILPSGEGPEVSASGVEDLSVLPSGEGHLEISTSGVEDLSVLPSGEGHLET
SSGVEDISRLPSGEGPEVSASGVEDLSVLPSGEDHLEISASGVEDLGVLPSGEDHLEISA
SGVEDISRLPSGEGPEVSASGVEDLSVLPSGEGHLEISASGVEDLSRLPSGGEDHLETSA
SGVGDLSGLPSGREGLEISASGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAP
EASGLPSGFSGEYSGVDLESGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEG
RGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPS
GFPDISGETSGLLEVSGQPSGFYGEISGVTELSGLASGQPEISGEASGILSGLGPPFGIT
DLSGEAPGIPDLSGQPSGLPEFSGTASGIPDLVSSAVSGSGESSGITFVDTSLVEVTPTT
FKEEEGLGSVELSGLPSGELGVSGTSGLADVSGLSSGAIDSSGFTSQPPEFSGLPSGVTE
VSGEASGAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILE
LSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSGEPASTPYFSGDFSGTTDVSGESSAATS
TSGEASGLPEVTLITSELVEGVTEPTVSQELGQRPPVTYTPQLFESSGEASASGDVPRFP
GSGVEVSSVPESSGETSAYPEAEVGASAAPEASGGASGSPNLSETTSTFHEADLEGTSGL
GVSGSPSAFPEGPTEGLATPEVSGESTTAFDVSVEASGSPSATPLASGDRTDTSGDLSGH
TSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTDASIPAS
AGGTDDSEATTTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDVCEIQKLCEEGWTK
FQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEG
DFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVA
CGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQGHVPTIRCQPSGHWEEPRITCTDP
ATYKRRLQKRSSRPLRRSHPSTAH
|
| External Links |
|---|
| GenBank ID Protein
| AAB38524.1 |
| UniProtKB/Swiss-Prot ID
| P13608 |
| UniProtKB/Swiss-Prot Entry Name
| PGCA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| U76615 |
| GeneCard ID
| ACAN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
