| Identification |
|---|
| BMDB Protein ID
| BMDBP02062 |
| Secondary Accession Numbers
| None |
| Name
| Galectin-9 |
| Synonyms
|
Not Available
|
| Gene Name
| LGALS9 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sugar binding |
| Specific Function
| Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth. Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function. Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation. Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection. Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells. Inhibits degranulation and induces apoptosis of mast cells. Induces maturation and migration of dendritic cells. Inhibits natural killer (NK) cell function. Can transform NK cell phenotype from peripheral to decidual during pregnancy. Astrocyte derived galectin-9 enhances microglial TNF production. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| LGALS9 |
| Gene Sequence
|
>1068 bp
ATGGCCTTCGGTGGTGCCCAGGCTTCCTACATAAACCCAGTTGTCCCCTTCACTGGGATG
ATCCAAGGGGGTCTCCAGGATGGACACAAGATCACCATCATTGGGGCCGTTCTTCCCTCA
GGCGGGAACAGGTTTGCTGTGAACCTTCAGACCGGCTATAACGACAGTGACATTGCCTTC
CACTTCAATCCTCGGTTTGAAGAGGGTGGGTATGTGGTCTGCAACACGAAGCAGAGAGGA
AGCTGGGGGACGGAGGAGAGGAAGATGCATATGCCCTTCCAGAGGGGGTGTTCATTTGAG
CTCTGCTTCCAGGTACAGAGCTCAGATTTCAGGGTGATGGTGAACGGGAACCTCTTCACG
CAGTATGCCCACCGCGTGCCCTTCCACCGCATCGATGCCATCAGCATCACGGGTGTCGTG
CAGCTGTCCTCCATCAGCTTCCAGAACATCCGCGCAGCTCCCAAGCAGCCCGCCTGCTCC
AAGGTGCAGTTCTCCCAGGCTGTCTGTCTCCCACCCAGGCCCAGGGGGCGCAAATCAAAT
CCTCCAGGGATCTGGCCAGCCAACTCGGCTCCCATTGCTCAGACCTTCGTCCACACCATA
CACAGCGCCCCTGGACAGATGTTCCCTAATCCCGTGATCCCACCCGCGGTGTATCCCAAC
CCGGTTTACCAGCTACCTTTCTTCACCTCCATCCTGGGTGGGCTGTACCCCTCCAAGAGC
ATCCTGGTGTCGGGCACCATCCTGCCCAGCGCTCAGAGGTTCTACATCAACCTGCGTTCA
GGGAGTGACATCGCCTTCCACCTGAACCCCCGCTTCAACGAGAATGCGGTGGTCCGCAAC
ACGCAGATCAACGGCTCCTGGGGGTCTGAGGAGCGAAGCCTGCCACGAGGGATGCCCTTC
TTCCGAGGCCAGAGCTTCTCGGTGTGGATCATGTGTGAAGGGCACTGCTTCAAGGTGGCC
GTGGACAGTCAGCACCTGTTTGAATACCACCACCGCCTGAAGAACCTGCCCGCCATCAAC
AACCTGGAGGTGGGGGGCGACATCCAGCTGACCCACGTGCAGACATAG
|
| Protein Properties |
|---|
| Number of Residues
| 355 |
| Molecular Weight
| 39334.0 |
| Theoretical pI
| 9.58 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Galectin-9
MAFGGAQASYINPVVPFTGMIQGGLQDGHKITIIGAVLPSGGNRFAVNLQTGYNDSDIAF
HFNPRFEEGGYVVCNTKQRGSWGTEERKMHMPFQRGCSFELCFQVQSSDFRVMVNGNLFT
QYAHRVPFHRIDAISITGVVQLSSISFQNIRAAPKQPACSKVQFSQAVCLPPRPRGRKSN
PPGIWPANSAPIAQTFVHTIHSAPGQMFPNPVIPPAVYPNPVYQLPFFTSILGGLYPSKS
ILVSGTILPSAQRFYINLRSGSDIAFHLNPRFNENAVVRNTQINGSWGSEERSLPRGMPF
FRGQSFSVWIMCEGHCFKVAVDSQHLFEYHHRLKNLPAINNLEVGGDIQLTHVQT
|
| External Links |
|---|
| GenBank ID Protein
| AAI04506.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHZ8 |
| UniProtKB/Swiss-Prot Entry Name
| LEG9_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC104505 |
| GeneCard ID
| LGALS9 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
