| Identification |
|---|
| BMDB Protein ID
| BMDBP02063 |
| Secondary Accession Numbers
| None |
| Name
| C-type lectin domain family 7 member A |
| Synonyms
|
Not Available
|
| Gene Name
| CLEC7A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sugar binding |
| Specific Function
| Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| CLEC7A |
| Gene Sequence
|
>606 bp
ATGGAATATCAATCTTCAGTAGAAAATTTGGATGAAGATGGATATACTCAATTAGACTTC
AGCTCTCGCAACATCACCAGGAGATCTGTAGTCTCAGAGAAAGGGCTTTGTGCTGCATCC
TCTCATTGGCGTCTGATTGCTGTGACTCTGGGCATTTTATGCTCAGTGATGCTGGTGATA
ACTGTGGTCCTGAGTACCTCGGGAGTTTTCTCTAGCTCTTGTCCCCCTAACTGGATCACA
CATGAGGATAGCTGTTATCTATTTAGCACACTATTAGATTCCTGGGATGGAAGTAAAAGA
CAATGCTTTCAACTGGGCTCCCATCTCCTGAAGATAGACAGCTCAAAAGAGTTGGAGTTT
ATATCAAGGCAAGTGTCTTCCCAGCCTGATCATTCATTTTGGATAGGGCTTTCTCGCCGT
CAGACAGAAGAACCATGGCTCTGGGAGGATGGCTCCACCTTGTTGTCTAACCTGTTCCAA
ATCAGAAGTACAGTTACCGAAAAAGACTCATCTCACAACTGTGCATGGATCCATGTGTCA
GACATTTACGACCAACTTTGTAGTGCGCATTCATACAGTATTTGTGAGAAGAAGTTGTCA
GTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 247 |
| Molecular Weight
| 27760.0 |
| Theoretical pI
| 5.57 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>C-type lectin domain family 7 member A
MEYQSSVENLDEDGYTQLDFSSRNITRRSVVSEKGLCAASSHWRLIAVTLGILCSVMLVI
TVVLSTSGIWRSSSGNNLLKSDSFPSRNKDNQSQPTQSSLEDSVIPTKALTTTGVFSSSC
PPNWITHEDSCYLFSTLLDSWDGSKRQCFQLGSHLLKIDSSKELEFISRQVSSQPDHSFW
IGLSRRQTEEPWLWEDGSTLLSNLFQIRSTVTEKDSSHNCAWIHVSDIYDQLCSVHSYSI
CEKKLSV
|
| External Links |
|---|
| GenBank ID Protein
| AAY22120.1 |
| UniProtKB/Swiss-Prot ID
| Q49BZ4 |
| UniProtKB/Swiss-Prot Entry Name
| CLC7A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY937382 |
| GeneCard ID
| CLEC7A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
