| Identification |
|---|
| BMDB Protein ID
| BMDBP02104 |
| Secondary Accession Numbers
| None |
| Name
| Protein lin-7 homolog C |
| Synonyms
|
Not Available
|
| Gene Name
| LIN7C |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in exocytosis |
| Specific Function
| Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| LIN7C |
| Gene Sequence
|
>594 bp
ATGGCGGCCCTGGGGGAGCCCGTGCGACTGGAGAGGGATATTTGTAGAGCAATTGAATTG
TTGGAAAAACTGCAAAGAAGTGGCGAGGTACCACCACAGAAACTTCAGGCTCTACAAAGA
GTCCTTCAGAGTGAATTCTGCAATGCTGTAAGAGAGGTATATGAACATGTCTACGAGACT
GTGGACATCAGTAGCAGTCCTGAAGTGAGAGCTAATGCAACTGCAAAGGCTACTGTTGCT
GCATTTGCTGCCAGCGAAGGGCATTCTCATCCTCGAGTTGTTGAGCTGCCAAAAACAGAA
GAAGGCCTTGGATTCAATATTATGGGAGGCAAAGAACAAAACTCTCCAATCTATATCTCT
CGAATAATTCCAGGTGGAATTGCTGATAGACATGGGGGCCTCAAGCGAGGAGATCAGCTC
CTTTCTGTTAATGGAGTGAGTGTTGAAGGAGAGCATCATGAAAAAGCTGTAGAGCTGCTG
AAAGCAGCGCAGGGAAAGGTTAAATTAGTAGTGCGGTATACACCCAAGGTCTTGGAAGAG
ATGGAGTCGCGCTTTGAAAAAATGCGATCAGCAAAACGCAGGCAACAGACCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 197 |
| Molecular Weight
| 21834.0 |
| Theoretical pI
| 8.7 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 8-28
- 53-73
- 93-115
- 120-142
- 148-168
- 229-249
- 264-284
- 304-324
- 331-351
- 355-375
|
| Protein Sequence
|
>Lin-7 homolog C
MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET
VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS
RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE
MESRFEKMRSAKRRQQT
|
| External Links |
|---|
| GenBank ID Protein
| AAI20125.1 |
| UniProtKB/Swiss-Prot ID
| Q0P5F3 |
| UniProtKB/Swiss-Prot Entry Name
| LIN7C_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120124 |
| GeneCard ID
| LIN7C |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
