| Identification |
|---|
| BMDB Protein ID
| BMDBP02105 |
| Secondary Accession Numbers
| None |
| Name
| Protein lin-7 homolog B |
| Synonyms
|
Not Available
|
| Gene Name
| LIN7B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| LIN7B |
| Gene Sequence
|
>606 bp
ATGGCTGCGCTGGTGGAGCCGCTGGGGCTGGAGCGGGAAGTGTCCCGGGCGGTGGAGCTC
CTCGAGCGGCTCCAGCGCAGCGGGGAGCTGCCCCCGCAGAAGCTGCAGGCCCTCCAGCGA
GTCCTGCAGAGCCGCTTCTGCTCTGCCATCCGAGAGGTGTATGAGCAGCTCTACGACACG
CTGGACATCACCGGCAGTGCTGAGATCCGGGCCCACGCCACGGCCAAGGCCACGGTGGCC
GCCTTCACAGCCAGTGAGGGCCATGCACATCCCAGGGTAGTGGAACTGCCCAAGACGGAT
GAGGGCCTGGGCTTCAACATCATGGGGGGCAAGGAGCAGAATTCACCTATCTACATCTCC
CGTGTCATCCCTGGGGGTGTGGCTGACCGCCACGGAGGCCTGAAGCGTGGGGACCAGCTG
CTGTCAGTGAATGGTGTGAGCGTTGAGGGCGAGCAGCATGAGAAGGCAGTGGAGCTTCTG
AAGGCTGCCCAGGGCTCGGTGAAGCTGGTGGTACGCTACACACCTCGAGTGCTGGAGGAG
ATGGAAGCCCGCTTTGAGAAGATGCGCTCCGCCCGGCGGCGCCAGCAACATCAGAGCTAC
TCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 201 |
| Molecular Weight
| 22280.0 |
| Theoretical pI
| 9.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 770-795
- 807-825
- 831-855
- 876-896
- 916-939
- 976-998
- 1004-1027
|
| Protein Sequence
|
>Lin-7 homolog B
MAALVEPLGLEREVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDT
LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYIS
RVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEE
MEARFEKMRSARRRQQHQSYS
|
| External Links |
|---|
| GenBank ID Protein
| AAI12699.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIB6 |
| UniProtKB/Swiss-Prot Entry Name
| LIN7B_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC112698 |
| GeneCard ID
| LIN7B |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
