| Identification |
|---|
| BMDB Protein ID
| BMDBP02128 |
| Secondary Accession Numbers
| None |
| Name
| Sterol regulatory element-binding protein cleavage-activating protein |
| Synonyms
|
Not Available
|
| Gene Name
| SCAP |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, release of the transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| SCAP |
| Gene Sequence
|
>3837 bp
ATGACCCTGACTGAAAGGCTGCGTGAGAAGATATCCCAGGCCTTCTACAACCATGGGCTG
TTCTGTGCGTCCTACCCCATCCCCATCATTCTCTTCACGGGGCTCTGCATCTTAGCCTGC
TGCTACCCACTGCTGAAGCTGCCCTTGCCAGGAACAGGACCTGTGGAATTCACCACTCCT
GTGAAAGATTACTCGCCCCCACCTCTGACCTCTGACCACAAGCCTGGAGAGCCCAATGAG
CAGCCAGAGTGGTACGTGGGGGCCCCGGTGGCTTATATCCAGCAGATATTTGTGAAATCT
TCCGTGTCTCCCTGGCACAAGAACCTCCTAGCAGTAGATGTGTTCCGCTCACCTCTGTCG
AGGGCATTCCAGCTGGTGGAGGAGATTCGGAACCACGTGCTGAAAGACAGCTCCGGGACC
AGGAGCCTGGAGGACGTGTGCCTGCAGGTGACTGACCTGCTGCCAGGCCTCAGGAAGCTC
CGCAACCTCCTGCCCGAGCATGGATGCCTGCTGCTCTCCCCCGGGAACTTCTGGCAGAAT
GACAGGGAGCGCTTCCACGCAGATCCCGACATCATCAGGACCATCCACCAGCACGAGCCC
AAAACCCTGCAGACCTCGGCCACACTCAAAGACCTGCTGTTTGGCGTCCCTGGGAAGTAC
AGCGGGGTGAGCCTGTACACCAGGAAGCGGCTGGTCTCATACACCATCACCCTGGTCTTC
CAGCACTACCACGCCAAGTTCCTGGGCAGCCTGCGGGCCCGCCTGATGCTCCTGCACCCC
AGCCCCAACTGCAGCCTCAGAGCAGAGAGCCTGGTCCATGTGCACTTCAAGGAGGAGATT
GGCATCGCTGAGCTCATCCCCCTGGTGACCACCTACATCATCCTGTTCGCCTACATCTAC
TTCTCCACACGCAAGATCGACATGGTCAAGTCCAAGTGGGGCCTGGCTCTGGCTGCCGTC
GTCACGGTGCTCAGCTCGCTGCTCATGTCTGTGGGGCTCTGCACACTCTTCGGCCTGACA
CCCACGCTCAATGGCGGGGAGATCTTCCCCTACCTGGTGGTGGTCATTGGGCTGGAGAAC
GTGCTGGTGCTCACCAAGTCCGTCGTCTCCACCCCGGTGGACCTCGAGGTGAAGCTGCGC
ATTGCCCAAGGCCTGAGCAGCGAGAGCTGGTCCATCATGAAGAACATGGCCACAGAGCTG
GGCATCGTCCTCATTGGCTACTTCACCCTAGTGCCTGCCATCCAGGAGTTCTGTCTTTTT
GCCGTCGTGGGGCTGGTGTCTGACTTTTTCCTTCAGATGCTGTTTTTCACCACTGTCCTG
TCCATTGACATTCGCCGGATGGAGCTGGCGGACCTGAACAAGCGGCTGCCCCCTGAGGCC
TGCCTGCCCCCAGCCAAGCCGGTGGGGCGGCCAACACGCTTTGAGCGGCAGCCGACTGTG
CGGCCATCCATGCCCCACACCATCACACTGCAGCCGTCCTCCTTCCGCAACCTGCGTCTC
CCCAAGCGGCTGCGTGTCATCTACTTCCTGGCCCGAACCCGCCTGGCACAGCGCCTCATC
ATGGCTGGCACGGTGGTGTGGATCGGCATCCTTGTGTACACGGACCCAGCTGGGCTGCGC
ACCTACCTGGCCGCCCAGGTAACGGAGCAGAGCCCGCTGGGCGAGGGTGCCCTGGCTCCT
CTGCCTGTGCCCAGTGGTGTGCTGCCTGCCAGCCACCCGGATCCTGCCTTTTCCATCTTC
CCGCCGGATGCCTCCAAGTTACCCGAGAACCAGACGTTGCCAGGGGAGCCGCCTGAGCCC
GGGGGTCTCGCCGAGGGCGTCCATGACAGCCCGGCCCCAGAGGTCACCTGGGGGCCCGAG
GACGAGGAGCTCTGGAGGAAACTGTCCTTCCGCCACTGGCCCACGCTCTTCAGCTATTAC
AACATCACACTGGCCAAGAGGTACGTCAGCCTGCTGCCTGTCATCCCCGTCACGCTCCGC
CTGAACCCGCGGGAGGCTCTGGAGGGCCGGCACCCTCAGGACGGCCGCAGCGCCTGGCCC
CCGCCCCGGCCCGGGCAGGGTGGGCTCTGGGAGGCCGGCCCCAAGGGGCCAGGCACGGCG
CAGGCGCAGAGAGACCTCACCCTGTACAAGGTGGCGGCACTTGGCCTGGCCTCAGGCATC
GTGCTTGTGCTGCTGCTGCTCTGCCTGTACCGTGTGCTCTGCCCGCGCAACTACGGGCAG
CCCGGCGCGGGGCCCGGCCGGCGGCGGCGGGGGGAGCTGCCCTGCGACGATTATGGCTAC
GCGCCCCCCGAGACGGAGATTGTGCCCCTGGTGCTGCGCGGGCACCTCATGGACATCGAG
TGTCTGGCCAGCGACGGGATGCTACTGGTGAGCTGTTGCCTGGCAGGCCACGTGTGTGTA
TGGGACGCGCAGACCGGAGACTGCCTCACCCGCATCCCGCACCCGGGGCAGCGGCGGGAC
AGCGGTGTTGGTAGCGGGCTGGAGACTCAGGAGACCTGGGAACGGCTGTCGGACGGCGGG
AAGGGTGGCCCGGAGGAGCCTGGGGACAGCCCTCCGCTGCGGCACCGGCCCCGGGGCCCT
CCACCCCCTGCCCTCTTTGGGGACCAGCCAGACCTCACCTGCTTGATTGACACCAACTTT
TCAGCGCGGCCACAGCTCCCCGAGCCGGCTCAGCCCGAGCCCCGGTACCGGGCGGGCCGC
CGTGCTCAAGACTCCGCAGGCTACGACTTCAGCCGCCTGGTGCAGCGCGTGTACCAGGAG
GGGGGCATGGCTCCCGTGCACACGCCAGCCCTGCGCCCACCCTCTCCCGGGCCCACGTTC
CCCCTGGCCCCTGAGGACGAGGCTGGCTTTCCTCCCGAGAAGAGCTGCCCGTCCCTCGCC
TGGGCCCCCAGCACAGATGGCTCCATCTGGAGTCTGGAGTTGCAGGGCAGCCTCATCGTG
GTGGGGCGGAGCAGTGGCCGGCTGGAGGTGTGGGACGCCATCGAGGGCACCCTGCGCTGC
AGCAGTGAGGAAGTGTCATCAGGCATCACGGCCCTCGTTTTCCTGGACAGAAGGATTGTG
GCCGCCCGACTCAATGGCTCCCTCGATTTCTTCTCTTTGGAGACCCACACTGCCCTCAGC
CCCCTGCAGTTCCGAGGGGCCCCGGGGCGGGGCAGTTCCCCTGCCTCCCCCGCGTGCAGC
AGCAGTGACAGGGTGGCTTGCCACCTGACCCACACCGTGCCCTGTGCACACCAGAAGCCC
ATCACAGCCCTGAAGGCCGCTGCCGGGCGCCTCGTGACTGGCAGCCAGGACCACACACTG
AGAGTGTTCCGCCTGGAGGATTCGTGCTGCCTCTTCACCCTGCAGGGCCACTCGGGGGCC
ATCACGACCGTGTATATTGACCAGACCATGGTGCTGGCCAGCGGAGGCCAAGACGGGGCC
ATCTGCCTGTGGGACGTGCTGACCGGCAGCCGGGTCAGCCACATGTTCGCTCACCGTGGG
GATGTCACCTCCCTCACCTGCACCACCTCGTGCGTCATCAGCAGTGGCCTGGACGACCTC
ATCAGCATCTGGGACCGCAGCACGGGCATCAAGCTCTACTCCATCCAGCAGGACCTGGGC
TGTGGCGCGAGCCTGGGTGTCATCTCAGACAACCTGCTGGTGACCGGCGGCCAGGGCTGT
GTTTCCTTTTGGGACCTGAACTACGGGGACCTGTTACAGACAGTCTACCTGGGCAAGAAC
AGCGAGGCCCAGCCGGCCCGCCAGATCCTGGTGCTGGACAACGCTGCCATTGTCTGCAAC
TTTGGCAGCGAGCTCAGCCTGGTGTACGTGCCCTCTGTGCTGGAGAAGCTGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1278 |
| Molecular Weight
| 139701.0 |
| Theoretical pI
| 7.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 19-39
- 280-300
- 313-333
- 345-365
- 402-422
- 424-444
- 519-539
- 708-728
|
| Protein Sequence
|
>Sterol regulatory element-binding protein cleavage-activating protein
MTLTERLREKISQAFYNHGLFCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFTTP
VKDYSPPPLTSDHKPGEPNEQPEWYVGAPVAYIQQIFVKSSVSPWHKNLLAVDVFRSPLS
RAFQLVEEIRNHVLKDSSGTRSLEDVCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQN
DRERFHADPDIIRTIHQHEPKTLQTSATLKDLLFGVPGKYSGVSLYTRKRLVSYTITLVF
QHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGIAELIPLVTTYIILFAYIY
FSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLEN
VLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIVLIGYFTLVPAIQEFCLF
AVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRLPPEACLPPAKPVGRPTRFERQPTV
RPSMPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILVYTDPAGLR
TYLAAQVTEQSPLGEGALAPLPVPSGVLPASHPDPAFSIFPPDASKLPENQTLPGEPPEP
GGLAEGVHDSPAPEVTWGPEDEELWRKLSFRHWPTLFSYYNITLAKRYVSLLPVIPVTLR
LNPREALEGRHPQDGRSAWPPPRPGQGGLWEAGPKGPGTAQAQRDLTLYKVAALGLASGI
VLVLLLLCLYRVLCPRNYGQPGAGPGRRRRGELPCDDYGYAPPETEIVPLVLRGHLMDIE
CLASDGMLLVSCCLAGHVCVWDAQTGDCLTRIPHPGQRRDSGVGSGLETQETWERLSDGG
KGGPEEPGDSPPLRHRPRGPPPPALFGDQPDLTCLIDTNFSARPQLPEPAQPEPRYRAGR
RAQDSAGYDFSRLVQRVYQEGGMAPVHTPALRPPSPGPTFPLAPEDEAGFPPEKSCPSLA
WAPSTDGSIWSLELQGSLIVVGRSSGRLEVWDAIEGTLRCSSEEVSSGITALVFLDRRIV
AARLNGSLDFFSLETHTALSPLQFRGAPGRGSSPASPACSSSDRVACHLTHTVPCAHQKP
ITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTVYIDQTMVLASGGQDGA
ICLWDVLTGSRVSHMFAHRGDVTSLTCTTSCVISSGLDDLISIWDRSTGIKLYSIQQDLG
CGASLGVISDNLLVTGGQGCVSFWDLNYGDLLQTVYLGKNSEAQPARQILVLDNAAIVCN
FGSELSLVYVPSVLEKLD
|
| External Links |
|---|
| GenBank ID Protein
| AAI48153.1 |
| UniProtKB/Swiss-Prot ID
| A6QM06 |
| UniProtKB/Swiss-Prot Entry Name
| SCAP_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC148152 |
| GeneCard ID
| SCAP |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
