| Identification |
|---|
| BMDB Protein ID
| BMDBP02135 |
| Secondary Accession Numbers
| None |
| Name
| Na(+)/H(+) exchange regulatory cofactor NHE-RF3 |
| Synonyms
|
Not Available
|
| Gene Name
| PDZK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| PDZK1 |
| Gene Sequence
|
>1563 bp
ATGGCCTCCACCTTCAACCCCCGAGAATGTAAGCTAACCAAACAGGAAGGGAATAGCTAT
GGCTTCTTCCTGCGAATTGAGAAGGACACTGACGGCCACCTGGTCCGGGTGATTGAGAAG
GGTAGCCCAGCAGAGAAGGCGGGTCTCCAGGATGGAGACAGAGTTCTTAGGATCAATGGT
GTCTTCGTGGACAAGGAAGAGCATATGCAGGTTGTGGATCTGGTCAGAAAGAGTGGGAAT
TCAGTGACTTTACTAGTTCTGGATGGGGATTCCTACGAGAAAGCCATGAAAAAGCAAGTA
GACTTGAAAGCGTTGGGTCAAAGTCAGGAGCCGAGTTTGAATGATAAGAAGGCGCCCTCT
GTGATGAACGGAGGAGCACAGATGTGGATGCAGCCACGGCTCTGCTACCTAGTGAAGGAG
GGGGGTAGCTATGGCTTCTCTCTGAAAACTGTCCAAGGTAAAAATGGAGTGTACATGACA
GATATAAAACCTCAAGGTGTGGCTATGAAAGCTGGAGTGCTGGCTGATGACCACTTGATT
GAAGTGAATGGAGAGAATGTAGAGGATGCCAGCCACGAGGAGGTGGTTGAAAAGGTGAAG
AAGTCTGGAAGCCGTGTCACATTCCTGCTTGTGGACAAGGAAACTGACAAGCACCATAGC
GAGCAGAAGATAAAAGTCAAGAGAGAAACAGCCAGTTTGAAACTGCTACCCTGCCAGCCC
CGTGTTGTAGAGATGAAGAAGGGAAGCAATGGCTATGGTTTCTACTTGAGGGAAAGCCCA
GAACAGAAAGGTCAAATCATCAAGGACATAGATCCCAAAAGTCCAGCAGAAAAGGCTGGC
TTGAAGAACAATGACCTGGTGGTTGCTGTCAATGGCAAGTCTGTGGAGTCCCTTGATCAT
GACAGTGTGGTGGAAATGATTAGAAAGGGTGGAGATCAGACCTCTCTGCTGGTGGTAGAC
AAAGAGACAGACAACATCTATAAACTGGCTGGCTTTTCTCCATTCTTCTACTATCAAAGC
CAAGAGCTGCCTAATGGTTCTGTCAAGGAGGTTCCAGCTCCTACTCCTGCTCCTCTGGAG
GTCTCAAGCCCAGAAACTACAGAGGAAGTAGGAGATCATAAGCCTAAACTCTGCAGGCTG
GCTAGAGGTGAAGATGGCTATGGCTTTCACTTAAACGCGGTTCGGGGTCAGCCAGGCTCA
TTCGTCAAAGAGGTGCAGAAGGGCGGCCCTGCTGATCTGGCTGGGCTGGAGGATGAGGAC
GTCATCATTGAGGTGAATGGAGTGAACATGCTGGATGAGTCCTATGAGAAGGTGGTGGAC
AGAATCCAGAGCAGTGGCAAGACTGTCACACTCTTAGTCTGTGGAAAGAAGGCCTATGAT
TATTTCCAGGCTAAGAAAATCCCTATCGTTTCCTCCATGGCTGATCCGCTGGATGATGAC
CCTGATCCTGATGAAGGAAGGCTGGAAGGATCAGAGCAAAACTCACACATGGCAGAAGAA
AGAGAACGAGCCCACAGTACAGCCTCTCATTCTTCTTCCAATTCTGAAGACACAGAGATG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 520 |
| Molecular Weight
| 57175.0 |
| Theoretical pI
| 5.11 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Na(+)/H(+) exchange regulatory cofactor NHE-RF3
MASTFNPRECKLTKQEGNSYGFFLRIEKDTDGHLVRVIEKGSPAEKAGLQDGDRVLRING
VFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAMKKQVDLKALGQSQEPSLNDKKAPS
VMNGGAQMWMQPRLCYLVKEGGSYGFSLKTVQGKNGVYMTDIKPQGVAMKAGVLADDHLI
EVNGENVEDASHEEVVEKVKKSGSRVTFLLVDKETDKHHSEQKIKVKRETASLKLLPCQP
RVVEMKKGSNGYGFYLRESPEQKGQIIKDIDPKSPAEKAGLKNNDLVVAVNGKSVESLDH
DSVVEMIRKGGDQTSLLVVDKETDNIYKLAGFSPFFYYQSQELPNGSVKEVPAPTPAPLE
VSSPETTEEVGDHKPKLCRLARGEDGYGFHLNAVRGQPGSFVKEVQKGGPADLAGLEDED
VIIEVNGVNMLDESYEKVVDRIQSSGKTVTLLVCGKKAYDYFQAKKIPIVSSMADPLDDD
PDPDEGRLEGSEQNSHMAEERERAHSTASHSSSNSEDTEM
|
| External Links |
|---|
| GenBank ID Protein
| AAI02214.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0X8 |
| UniProtKB/Swiss-Prot Entry Name
| NHRF3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102213 |
| GeneCard ID
| PDZK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
