| Identification |
|---|
| BMDB Protein ID
| BMDBP02136 |
| Secondary Accession Numbers
| None |
| Name
| Excitatory amino acid transporter 3 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC1A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine (By similarity). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5 (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| SLC1A1 |
| Gene Sequence
|
>1575 bp
ATGGGGAAGCCGGCGAGGAAGGGATGCGACTGGAAGCGCTTCCTGAGGAATAATTGGCTG
CTACTTTCCACCGTGGTCGCGGTGGTGCTAGGGATTGTTATAGGAGTCTTGGTTCGAGAA
TACAGCAAGCTATCTAACCTGGAGAAATTCTACTTTTCCTTTCCTGGAGAAATTCTGATG
AGAATGCTGAAACTCGTCATTTTACCATTAATTGTATCCAGCATGATTACAGGTGTTGCT
ACACTGGATTCCAACGTATCTGGAAAAATTGGTCTGCGTGCTGTTGTATATTATTTCTGT
ACCACTCTCATTGCTGTAATTTTAGGTATCGTGCTGGTGGTGAGCATCAAGCCTGGTGTC
ACCCAGAAAGTGAATGAGATTGACAGGACAGGGAACACCCCTGAAGTTAGCACAGTGGAT
GCCATGTTAGACCTGATCAGGAATATGTTCCCTGAGAACCTTGTCCAAGCCTGTTTTCAG
CAGTACAAAACCACACGTGAAGAAGTGGAGCTTTCTGAGGAGCCAGGGACAAACAGCACG
GAAGCGACTGTCACAGCCATCATGACAACTGCAATTTCCAAGAACAAAACAAAGGAATAC
AAAGTCGTAGGCATGTATTCAGATGGCATAAATGTCCTGGGCTTGATCGTCTTTTGCCTC
GTTCTGGGAATTGTCATTGGGAGAAAATGGGAAAAAGGACAGATTCTGGTGGATTTCTTC
AATGCTCTGAGTGATGCAACCATGAAAATCGTTCAGATCATTATGTGCTACATGCCGATT
GGTATTTTGTTCCTGATTGCCGGGAAGATCATAGAAGTTGAAGACTGGGAAATATTCCGC
AAACTGGGCCTTTACATGGCCACCGTCCTGAGTGGGCTTGCAATCCACTCCATTGTAATT
CTCCCACTGATATATTTCATAATTGTACGAAAGAACCCTTTCCAGTTCGCCATGGGAATG
GCCCAGGCTCTTCTGACAGCTCTCATGATCTCCTCCAGTTCAGCAACACTGCCTGTCACT
TTCCGCTGCGCTGAAGAGAAGAACCGGGTGGACAAGAGGATCACTAGATTTGTATTACCC
GTTGGTGCTACGATCAACATGGATGGGACTGCACTCTATGAAGCAGTGGCGGCCGTGTTT
ATTGCACAGTTGAATGATTTGGACTTGAGCGTTGGGCAGATCATCACTATCAGTGTCACT
GCCACCGCCGCCAGCATCGGAGCTGCCGGTGTGCCCCAGCCCGGCCTGGTGACCATGGTG
ATTGTGCTGAGTGCTGTGGGCCTGCCCGCGGAGGATGTCACCCTCATCATCGCTGTTGAC
TGGCTCCTGGACCGGTTCAGGACCATGGTGAATGTCCTTGGAGATGCCTTTGGGACTGGC
ATTGTGGAGAAGCTCTCCAAGAAGGAGTTGGAGCAAATGGATGTCTCATCAGAGGTCAAC
ATCGTGAACCCCTTCACCTTGGAATCCACAGCACTTGACAATGAGGACTCAGACACCAAG
AAGTCCTACGTCAACGGAGGCTTTGCCGTCGACAAGTCCGATACCATCTCGTTCACCCAG
ACCTCACAGTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 524 |
| Molecular Weight
| 57297.0 |
| Theoretical pI
| 5.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 19-38
- 62-82
- 94-114
- 206-229
- 239-266
- 287-308
- 354-380
- 441-462
|
| Protein Sequence
|
>Excitatory amino acid transporter 3
MGKPARKGCDWKRFLRNNWLLLSTVVAVVLGIVIGVLVREYSKLSNLEKFYFSFPGEILM
RMLKLVILPLIVSSMITGVATLDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVNEIDRTGNTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTTREEVELSEEPGTNST
EATVTAIMTTAISKNKTKEYKVVGMYSDGINVLGLIVFCLVLGIVIGRKWEKGQILVDFF
NALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSIVI
LPLIYFIIVRKNPFQFAMGMAQALLTALMISSSSATLPVTFRCAEEKNRVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLSVGQIITISVTATAASIGAAGVPQPGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFTLESTALDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
|
| External Links |
|---|
| GenBank ID Protein
| AAB16815.1 |
| UniProtKB/Swiss-Prot ID
| Q95135 |
| UniProtKB/Swiss-Prot Entry Name
| EAA3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U72534 |
| GeneCard ID
| SLC1A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
