| Identification |
|---|
| BMDB Protein ID
| BMDBP02139 |
| Secondary Accession Numbers
| None |
| Name
| Excitatory amino acid transporter 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC1A3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7723632). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| Not Available |
| SNPs
| SLC1A3 |
| Gene Sequence
|
>1629 bp
ATGACGAAAAGCAATGGAGAAGAGGCCAGGTTGGGAGGCAGGATGGAGAGATTCCAGCAA
GGGGTCCGTAAACGCACACTGTTGGCCAAGAAGAAAGTGCAGAACATCACAAAGGAGGAC
GTTAAAAGTTACCTATTTCGGAATGCATTTGTGCTGCTCACGGTCACTGCAGTCATTGTG
GGTACAATCCTTGGATTTACCCTCCGACCATACAGAATGAGCTACCGGGAAGTCAAGTAC
TTCTCTTTTCCTGGGGAGCTCCTGATGAGGATGCTACAGATGCTGGTGTTACCACTCATC
ATCTCCAGTCTCGTCACAGGAATGGCGGCCCTAGATAGTAAGGCATCAGGAAAGATGGGG
ATGCGAGCTGTAGTCTATTACATGACTACGACCATCATTGCCGTGGTGATTGGCATAATC
ATTGTTATCATCATCCATCCTGGGAAGGGCACAAAGGAAAACATGCACAGAGAAGGCAAA
ATTGTACAAGTGACAGCTGCAGACGCCTTCCTGGACTTGATCAGGAATATGTTCCCTCCA
AATCTGGTGGAAGCTTGCTTTAAACAGTTTAAAACCAACTATGAGAAGAGGAGCTTTAAA
GTGCCCATCCAGCCCAACGAAACACTCGTGGGCGCCGTGATAAACAATGTGTCAGAGGCC
ATGGAGACTCTGACGAGGATCACAGAAGAGTTAGTCCCAGTCCCAGGGTCTGTGAATGGG
GTCAATGCCCTAGGACTAGTTGTCTTCTCCATGTGCTTCGGATTTGTGATTGGAAACATG
AAGGAGCAGGGCCAGGCCCTGCGAGAGTTCTTTGATTCTCTCAACGAAGCCATCATGAGA
TTGGTAGCAGTGATCATGTGGTACGCCCCTCTGGGCATACTCTTCCTGATTGCAGGGAAA
ATTGTTGAGATGGAAGACATGGGAGTGATCGGGGGACAGCTGGCCATGTACACAGTGACA
GTCATCGTGGGCTTGCTCATCCATGCTGTCATTGTCCTACCCCTCCTCTACTTCCTGGTA
ACGCGGAAAAACCCCTGGGTTTTCATCGGAGGTTTGCTGCAAGCGCTCATCACAGCTCTG
GGAACTTCCTCCAGCTCCGCCACCCTACCCATCACCTTCAAGTGCCTGGAAGAGAACAAT
GGCGTGGACAAACGCGTTACCAGATTCGTGCTCCCGGTGGGGGCCACCATCAACATGGAT
GGGACCGCCCTCTATGAGGCTTTGGCTGCCATTTTCATTGCTCAAGTTAACAACTTCGAA
CTGAACTTTGGACAGATTATTACAATCAGCATCACAGCTACGGCTGCCAGTATTGGGGCA
GCTGGGATTCCTCAGGCAGGCCTGGTCACCATGGTCATCGTGCTGACATCTGTGGGCCTG
CCCACCGACGACATCACACTCATCATCGCGGTGGACTGGTTCCTGGACCGCCTTCGCACC
ACCACCAACGTGTTGGGAGACTCTCTAGGAGCTGGCATTGTTGAACACTTGTCACGACAT
GAACTGAAGAACCGGGATGTCGAAATGGGTAACTCAGTGATTGAAGAGAATGAAATGAAG
AAACCATATCAGCTGATTTCCCAGGAAAGCGAAATTGAAAAATCCATGGACAGTGAGACC
AAGATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 542 |
| Molecular Weight
| 59591.0 |
| Theoretical pI
| 8.4 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 48-68
- 87-108
- 123-145
- 237-260
- 270-297
- 319-340
- 386-412
- 473-494
|
| Protein Sequence
|
>Excitatory amino acid transporter 1
MTKSNGEEARLGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVQVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQPNETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLISQESEIEKSMDSET
KM
|
| External Links |
|---|
| GenBank ID Protein
| BAA11527.1 |
| UniProtKB/Swiss-Prot ID
| P46411 |
| UniProtKB/Swiss-Prot Entry Name
| EAA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D82056 |
| GeneCard ID
| SLC1A3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
