Showing Protein Angiopoietin-related protein 4 (BMDBP02145)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02145 |
| Secondary Accession Numbers | None |
| Name | Angiopoietin-related protein 4 |
| Synonyms | Not Available |
| Gene Name | ANGPTL4 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in receptor binding |
| Specific Function | Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 7 |
| Locus | Not Available |
| SNPs | ANGPTL4 |
| Gene Sequence |
>1233 bp ATGCGCTGTGCGCCGACAGCCGGAGCAGCCCTGATGCTGTGCGCCGCCACCGCCGGGCTG CTGAGCGCTCAGGGCCGCCCGGAGCCTCCCGAGACGCCGCGCTTTGCTTCCTGGGACGAG GTGAACGTGCTGGCACACGGCCTCTTGCAGCTCGGCCACGGGCTGCGCGAACACGTGGAG CGCACCCGTGGGCAGCTGGGCGAGCTGGAACGGCGTCTGGGCGCGTGTGGGGCCGCCTGC AAGGATCCTGAGGGGTCCGCCGCGCCTCCGCGTGCCCAGGCCAATTTGGTCAATCCCGGC GGCGGCGACGCCTCCCCAGAAACCCTCCGCAGCTTGAAGACTCAGCTGGAGGCTCAGAAC AGCAGGATCCAGCAACTCTTCCAGAAGGTGGCCCAGCAGCAGCGGCACTTGGAGAAGCAG CAGCTGCGAATCCAGAATCTACAGAGCCAGATGGATCACCTGGCCCCCAGGCACCTGGGC CACGAGATGGCCAAGCCCGCCAGGAGGAAGAGGCTGCCCAAGATGGCCCAGCTTGCTGGC CCAGCTCACAATATCAGCCGCCTGCACAGACTGCCCAGGGACTGCCAGGAGCTGTTTGAA GAGGGAGAGAGGGAAAGTGGATTGTTCCAGATCCAGCCCCAGGGATCCCCGCCTTTCCTG GTTAACTGCAAAATGACCTCAGATGGAGGCTGGACCGTAATTCAGAGGCGTCAGGATGGC TCCGTGGACTTTAACCAGCCCTGGGAAGCCTACAAAGATGGCTTCGGAGACCCCCAAGGC GAGTTCTGGCTGGGCCTGGAGAAGGTGCATCACATCCTTGGGGACCGTGGCAGCCGCCTG GCTGTGCAGCTGCAGGACTGGGAGGGCAATGCCGAGTCCTTGCAGTTCCCCATCCACCTG GGGGGTGAAGACACCGCCTACAGCCTGCAGCTCACGCCACCGGTGGCCAGCAAACTGGGC GCCACCACCTTCTCGCCCAGTGGCCTCTCCCTGCCCTTCTCCACTTGGGACCAGGACCAC GACCTCCGCGGAGACAAGAACTGCGCCAGGAGCCTCTCTGGTGGCTGGTGGTTTGGCACC TGCAGTCACTCCAACCTGAACGGCCAGTATTTCCACTCCATTCCAAGGCAGCGGCAGCAG CGTAAGAAGGGCATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCACTGCAGGCCACC ACCATCCTGGTACAGCCCACAGCGGCCTCCTAG |
| Protein Properties | |
| Number of Residues | 410 |
| Molecular Weight | 45553.0 |
| Theoretical pI | 8.93 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions |
|
| Protein Sequence |
>Angiopoietin-related protein 4 MRCAPTAGAALMLCAATAGLLSAQGRPEPPETPRFASWDEVNVLAHGLLQLGHGLREHVE RTRGQLGELERRLGACGAACKDPEGSAAPPRAQANLVNPGGGDASPETLRSLKTQLEAQN SRIQQLFQKVAQQQRHLEKQQLRIQNLQSQMDHLAPRHLGHEMAKPARRKRLPKMAQLAG PAHNISRLHRLPRDCQELFEEGERESGLFQIQPQGSPPFLVNCKMTSDGGWTVIQRRQDG SVDFNQPWEAYKDGFGDPQGEFWLGLEKVHHILGDRGSRLAVQLQDWEGNAESLQFPIHL GGEDTAYSLQLTPPVASKLGATTFSPSGLSLPFSTWDQDHDLRGDKNCARSLSGGWWFGT CSHSNLNGQYFHSIPRQRQQRKKGIFWKTWRGRYYPLQATTILVQPTAAS |
| External Links | |
| GenBank ID Protein | ABC84490.1 |
| UniProtKB/Swiss-Prot ID | Q2KJ51 |
| UniProtKB/Swiss-Prot Entry Name | ANGL4_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | DQ355521 |
| GeneCard ID | ANGPTL4 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |