Showing Protein Hypoxia-inducible factor 1-alpha (BMDBP02155)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02155 |
| Secondary Accession Numbers | None |
| Name | Hypoxia-inducible factor 1-alpha |
| Synonyms | Not Available |
| Gene Name | HIF1A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Signal transduction mechanisms |
| Specific Function | Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 10 |
| Locus | Not Available |
| SNPs | HIF1A |
| Gene Sequence |
>2472 bp ATGGAGGGCGCCGGGGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAG AAGTCTAGAGATGCAGCCAGATCTCGTCGAAGTAAAGAGTCTGAAGTTTTTTATGAGCTT GCTCATCAGTTGCCACTCCCCCATAATGTAAGCTCGCATCTTGATAAGGCTTCTGTTATG AGGCTCACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATT GAAGATGAAATGAAGGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTT ATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATG GGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGAC CACGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAG CAAAATACACAGCGGAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGGGGGAGA ACTATGAACATAAAATCTGCAACATGGAAAGTACTTCACTGCACAGGCCATATTCATGTA TACGATACCAACAGTAACCAATCTCAGTGTGGGTATAAGAAACCACCGATGACGTGCTTG GTGCTGATTTGTGAACCCATTCCTCATCCATCAAATATTGAAATTCCTTTAGACAGCAAG ACTTTTCTCAGTCGTCACAGTCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACA GAATTGATGGGATATGAGCCAGAAGAACTTTTGGGCCGCTCAATTTATGAATATTATCAT GCCTTGGACTCTGACCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTC ACAACAGGACAGTACAGAATGCTTGCCAAAAGAGGTGGATATGTCTGGATAGAAACTCAA GCAACTGTCATATATAACACTAAGAACTCTCAGCCCCAGTGCATTGTATGTGTAAATTAT GTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTT CTCAAACCAGTTGAATCTTCAGACATGAAAATGACTCAGCTATTCACCAAAGTTGAATCA GAAGATACAAGCAGTCTCTTTGATAAACTTAAGAAGGAGCCTGATGCTTTAACTTTGCTG GCCCCAGCTGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAATGACACAGAGACT GATGACCAACAACTTGAGGAAGTTCCATTGTATAATGATGTAATGCTCCCCTCATCTAAT GAGAAATTGCAGAATATAAATTTGGCAATGTCTCCATTACCTGCCTCTGAAACTCCAAAG CCACTTAGAAGTAGTGCTGACCCTGCACTCAACCAAGAAGTTGCATTAAAGTTAGAACCA AATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAAGATCAGCCAGCTAGT CCTTCTGATGGAAGCACCAGACAAAGTTCACCTGAGCCTAACAGTCCCAGTGAATATTGT TTTGATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAGAAACTTTTT GCTGAAGATACAGAAGCAAAGAATCCATTTTCCACTCAGGACACTGATTTAGACTTGGAG ATGTTAGCTCCTTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTG TCACCACTGGAAAACAGTTCTACAAGTCCTCAGAGTGCAAGCACAAATACAGTATTCCAG CCCACTCAAATGCAAAAACCTCCTATAGCCACCGTCACTACCACAGCCACCAGTGATGAA TTGAAAACAGTGACAAAAGATGGTATGGAAGACATTAAAATACTGATTGCATTTCCATCT CCTCCCCACGTACCTAAAGAACCTCCTTGTGCCACAACGTCACCATATAGTGATACTGGA AGTCGGACAGCCTCACCCAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCT CATCCAAGAAGCCCTAATGTGTTATCTGTCGCTTTGAGTCAAAGAACTACTGCTCCTGAG GAAGAACTAAATCCAAAGATACTAGCTTTGCAGAATGCTCAGAGAAAGCGAAAAATTGAA CATGATGGTTCACTTTTTCAAGCAGTAGGAATTGGAACATTATTACAGCAACCAGATGAT CGTGCAACTACCACATCACTTTCTTGGAAACGTGTAAAAGGATGCAAATCTAGTGAACAA AATGGAATGGAGCAAAAGACAATTATTTTAATACCCTCTGATTTAGCATGTAGACTGCTG GGGCAATCAATGGATGAGAGTGGACTACCACAGCTGACCAGTTATGATTGTGAAGTTAAT GCTCCTATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGAGCTTTGGAT CAAGTTAACTGA |
| Protein Properties | |
| Number of Residues | 823 |
| Molecular Weight | 92128.0 |
| Theoretical pI | 4.93 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Hypoxia-inducible factor 1 alpha MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM RLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR TMNIKSATWKVLHCTGHIHVYDTNSNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV TTGQYRMLAKRGGYVWIETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET DDQQLEEVPLYNDVMLPSSNEKLQNINLAMSPLPASETPKPLRSSADPALNQEVALKLEP NPESLELSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNEFKLELVEKLF AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLENSSTSPQSASTNTVFQ PTQMQKPPIATVTTTATSDELKTVTKDGMEDIKILIAFPSPPHVPKEPPCATTSPYSDTG SRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTAPEEELNPKILALQNAQRKRKIE HDGSLFQAVGIGTLLQQPDDRATTTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLL GQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN |
| External Links | |
| GenBank ID Protein | BAA78675.1 |
| UniProtKB/Swiss-Prot ID | Q9XTA5 |
| UniProtKB/Swiss-Prot Entry Name | HIF1A_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AB018398 |
| GeneCard ID | HIF1A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |