| Identification |
|---|
| BMDB Protein ID
| BMDBP02155 |
| Secondary Accession Numbers
| None |
| Name
| Hypoxia-inducible factor 1-alpha |
| Synonyms
|
Not Available
|
| Gene Name
| HIF1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). |
| Pathways
|
- Ahr Signal Transduction Pathway
- Circadian Rhythms
- Succinate Signalling
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| HIF1A |
| Gene Sequence
|
>2472 bp
ATGGAGGGCGCCGGGGGCGCGAACGACAAGAAAAAGATAAGTTCTGAACGTCGAAAAGAG
AAGTCTAGAGATGCAGCCAGATCTCGTCGAAGTAAAGAGTCTGAAGTTTTTTATGAGCTT
GCTCATCAGTTGCCACTCCCCCATAATGTAAGCTCGCATCTTGATAAGGCTTCTGTTATG
AGGCTCACCATCAGCTATTTGCGTGTGAGGAAACTTCTGGATGCTGGTGATTTGGATATT
GAAGATGAAATGAAGGCACAGATGAATTGCTTTTATTTGAAAGCCTTGGATGGTTTTGTT
ATGGTTCTCACAGATGATGGTGACATGATTTACATTTCTGATAATGTGAACAAATACATG
GGATTAACTCAGTTTGAACTAACTGGACACAGTGTGTTTGATTTTACTCATCCATGTGAC
CACGAGGAAATGAGAGAAATGCTTACACACAGAAATGGCCTTGTGAAAAAGGGTAAAGAG
CAAAATACACAGCGGAGCTTTTTTCTCAGAATGAAGTGTACCCTAACTAGCCGGGGGAGA
ACTATGAACATAAAATCTGCAACATGGAAAGTACTTCACTGCACAGGCCATATTCATGTA
TACGATACCAACAGTAACCAATCTCAGTGTGGGTATAAGAAACCACCGATGACGTGCTTG
GTGCTGATTTGTGAACCCATTCCTCATCCATCAAATATTGAAATTCCTTTAGACAGCAAG
ACTTTTCTCAGTCGTCACAGTCTGGATATGAAATTTTCTTATTGTGATGAAAGAATTACA
GAATTGATGGGATATGAGCCAGAAGAACTTTTGGGCCGCTCAATTTATGAATATTATCAT
GCCTTGGACTCTGACCATCTGACCAAAACTCATCATGATATGTTTACTAAAGGACAAGTC
ACAACAGGACAGTACAGAATGCTTGCCAAAAGAGGTGGATATGTCTGGATAGAAACTCAA
GCAACTGTCATATATAACACTAAGAACTCTCAGCCCCAGTGCATTGTATGTGTAAATTAT
GTTGTGAGTGGTATTATTCAGCACGACTTGATTTTCTCCCTTCAACAAACAGAATGTGTT
CTCAAACCAGTTGAATCTTCAGACATGAAAATGACTCAGCTATTCACCAAAGTTGAATCA
GAAGATACAAGCAGTCTCTTTGATAAACTTAAGAAGGAGCCTGATGCTTTAACTTTGCTG
GCCCCAGCTGCTGGAGACACAATCATATCTTTAGATTTTGGCAGCAATGACACAGAGACT
GATGACCAACAACTTGAGGAAGTTCCATTGTATAATGATGTAATGCTCCCCTCATCTAAT
GAGAAATTGCAGAATATAAATTTGGCAATGTCTCCATTACCTGCCTCTGAAACTCCAAAG
CCACTTAGAAGTAGTGCTGACCCTGCACTCAACCAAGAAGTTGCATTAAAGTTAGAACCA
AATCCAGAGTCACTGGAACTTTCTTTTACCATGCCCCAGATTCAAGATCAGCCAGCTAGT
CCTTCTGATGGAAGCACCAGACAAAGTTCACCTGAGCCTAACAGTCCCAGTGAATATTGT
TTTGATGTGGATAGTGATATGGTCAATGAATTCAAGTTGGAATTGGTAGAGAAACTTTTT
GCTGAAGATACAGAAGCAAAGAATCCATTTTCCACTCAGGACACTGATTTAGACTTGGAG
ATGTTAGCTCCTTATATCCCAATGGATGATGACTTCCAGTTACGTTCCTTCGATCAGTTG
TCACCACTGGAAAACAGTTCTACAAGTCCTCAGAGTGCAAGCACAAATACAGTATTCCAG
CCCACTCAAATGCAAAAACCTCCTATAGCCACCGTCACTACCACAGCCACCAGTGATGAA
TTGAAAACAGTGACAAAAGATGGTATGGAAGACATTAAAATACTGATTGCATTTCCATCT
CCTCCCCACGTACCTAAAGAACCTCCTTGTGCCACAACGTCACCATATAGTGATACTGGA
AGTCGGACAGCCTCACCCAACAGAGCAGGAAAAGGAGTCATAGAACAGACAGAAAAATCT
CATCCAAGAAGCCCTAATGTGTTATCTGTCGCTTTGAGTCAAAGAACTACTGCTCCTGAG
GAAGAACTAAATCCAAAGATACTAGCTTTGCAGAATGCTCAGAGAAAGCGAAAAATTGAA
CATGATGGTTCACTTTTTCAAGCAGTAGGAATTGGAACATTATTACAGCAACCAGATGAT
CGTGCAACTACCACATCACTTTCTTGGAAACGTGTAAAAGGATGCAAATCTAGTGAACAA
AATGGAATGGAGCAAAAGACAATTATTTTAATACCCTCTGATTTAGCATGTAGACTGCTG
GGGCAATCAATGGATGAGAGTGGACTACCACAGCTGACCAGTTATGATTGTGAAGTTAAT
GCTCCTATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGAGCTTTGGAT
CAAGTTAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 823 |
| Molecular Weight
| 92128.0 |
| Theoretical pI
| 4.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hypoxia-inducible factor 1 alpha
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWIETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSSNEKLQNINLAMSPLPASETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLENSSTSPQSASTNTVFQ
PTQMQKPPIATVTTTATSDELKTVTKDGMEDIKILIAFPSPPHVPKEPPCATTSPYSDTG
SRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTAPEEELNPKILALQNAQRKRKIE
HDGSLFQAVGIGTLLQQPDDRATTTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLL
GQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
|
| External Links |
|---|
| GenBank ID Protein
| BAA78675.1 |
| UniProtKB/Swiss-Prot ID
| Q9XTA5 |
| UniProtKB/Swiss-Prot Entry Name
| HIF1A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB018398 |
| GeneCard ID
| HIF1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
