| Identification |
|---|
| BMDB Protein ID
| BMDBP02161 |
| Secondary Accession Numbers
| None |
| Name
| Tricarboxylate transport protein, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| SLC25A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. |
| Pathways
|
- LPS and Citrate Signaling and Inflammation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| SLC25A1 |
| Gene Sequence
|
>936 bp
ATGGCTGCGGCTCGCGCACCCCGCGCTCTGACCTCTGCCTCGCCTGGGTCTGGGAAAGCC
AAACTGACACACCCAGGGAAGGCGATCCTAGCAGGCGGCCTGGCTGGCGGCATCGAAATC
TGCATCACTTTCCCCACCGAGTACGTGAAGACGCAGCTGCAGCTGGACGAGCGCTCGCAC
CCGCCGCGCTACCGGGGCATCGGGGACTGCGTGCGGCAGACGGTTCGCAGCCATGGGCTC
CTGGGCCTGTACCGCGGCCTTAGCTCCCTGCTCTACGGCTCCATCCCCAAGGCGGCCGTC
AGGTTCGGGACGTTCGAATTTCTCAGCAACCACATGCGGGACGCCCAGGGACGGCTGGAC
AGCACGCGCGGGCTGCTGTGCGGCCTGGGCGCCGGAGTGCCAGAGGCCGTGGTGGTCGTG
TGCCCCATGGAGACCATCAAGGTGAAATTTATCCATGACCAGACCTCTGCCAGCCCCAAA
TACCGAGGATTCTTCCACGGGGTCAGGGAGATCGTGCGGGAACAGGGGCTGAAGGGGACG
TATCAAGGCCTCACAGCCACCGTGCTGAAGCAGGGATCCAATCAGGGCATCCGCTTCTTC
GTCATGACTTCCCTGCGCAACTGGTACCGAGGAGACAACCCCAACAAACCCATGAACCCA
CTGATCACTGGTGTGTTCGGAGCCATCGCAGGCGCAGCCAGTGTCTTCGGGAACACTCCA
CTGGACGTGATCAAGACCCGGATGCAGGGACTGGAAGCACACAAGTACCGGAACACGTTG
GACTGCGGCCTGCAGATCCTGAGGAACGAGGGACTCAAGGCGTTCTACAAGGGCACTGTC
CCGCGCCTCGGCCGAGTCTGCCTGGACGTGGCCATCGTGTTCATCATCTACGACGAGGTG
GTGAAGCTTCTCAACAAAGTGTGGAAGGCGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 311 |
| Molecular Weight
| 33876.0 |
| Theoretical pI
| 10.41 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 29-46
- 86-105
- 129-143
- 183-202
- 224-241
- 278-297
|
| Protein Sequence
|
>Tricarboxylate transport protein, mitochondrial
MAAARAPRALTSASPGSGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH
PPRYRGIGDCVRQTVRSHGLLGLYRGLSSLLYGSIPKAAVRFGTFEFLSNHMRDAQGRLD
STRGLLCGLGAGVPEAVVVVCPMETIKVKFIHDQTSASPKYRGFFHGVREIVREQGLKGT
YQGLTATVLKQGSNQGIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTP
LDVIKTRMQGLEAHKYRNTLDCGLQILRNEGLKAFYKGTVPRLGRVCLDVAIVFIIYDEV
VKLLNKVWKAD
|
| External Links |
|---|
| GenBank ID Protein
| CAA66375.1 |
| UniProtKB/Swiss-Prot ID
| P79110 |
| UniProtKB/Swiss-Prot Entry Name
| TXTP_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X97773 |
| GeneCard ID
| SLC25A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
