Showing Protein Urea transporter 1 (BMDBP02167)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02167 |
| Secondary Accession Numbers |
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| Name | Urea transporter 1 |
| Synonyms | Not Available |
| Gene Name | SLC14A1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in urea transmembrane transporter activity |
| Specific Function | Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means. |
| Pathways |
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| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 24 |
| Locus | Not Available |
| SNPs | SLC14A1 |
| Gene Sequence |
>1155 bp ATGGATGACAACCCCACTGCAGTTAAATTGGACCAGGGTGGAAATCAGGCTCCACAAGGT CGAGGCAGAAGATGCCTCCCCAAGGCACTTGGCTATATCACTGGTGACATGAAAGAATTT GCCAACTGGCTTAAAGACAAACCCCAGGCTCTGCAGTTCGTCGACTGGGTTCTTCGGGGG ATATCCCAAGTTGTGTTTGTCAGCAACCCCATAAGTGGAATCCTGATTCTGGTGGGACTC CTGGTCCAGAATCCCTGGTGTGCACTCAATGGCTGTGTGGGAACAGTGGTCTCCACCCTG ACGGCCCTGTTACTCAGCCAGGACAGGTCCGCCATTACAGCGGGGCTCCAGGGCTACAAC GCTACCCTGGTGGGAATCCTCATGGCCATCTATTCGGACAAGGGAAACTATTTCTGGTGG CTGTTATTCCCTGTATCTGCTATGTCCATGACGTGTCCAGTCTTCTCGAGTGCCTTGAAC TCCGTGTTGAGCAAATGGGACCTGCCTGTCTTCACTCTGCCCTTCAATATGGCGTTGTCA ATGTACCTTTCTGCCACGGGACATTACAATCCATTTTTCCCAAGCACCTTGATCACACCT GTCACCTCAGTTCCCAATGTCACCTGGCCTGACCTCAGTGCCCTGCAGCTGCTGAAGTCC CTGCCTGTGGGTGTGGGTCAGATATATGGCTGCGATAATCCGTGGACAGGGGGCATCTTC CTAGGCGCCATCCTCCTCTCCTCCCCACTCATGTGCCTGCACGCTGCAATCGGGTCCTTG CTGGGGATAATAGCAGGACTCAGTCTTTCAGCTCCATTTGAGGACATCTACGCTGGACTC TGGGGCTTCAACAGCTCTCTAGCTTGCATTGCAATTGGAGGAACGTTCATGGCACTCACC TGGCAAACCCACCTCCTGGCTCTTGCCTGTGCCCTGTTCACCGCCTACCTGGGAGCCAGC ATGTCACACGTGATGGCTGTGGTCGGATTGCCATCTGGTACCTGGCCCTTCTGTTTAGCC ACACTACTGTTCCTCCTGCTGACCACAAAAAACCCCAACATCTACAAGATGCCCATCAGT AAAGTCACTTATCCTGAGGAAAACCGCATCTTCTACCTACAATCCAGGAAAAGGACGGTT CAAGGGCCTTTGTGA |
| Protein Properties | |
| Number of Residues | 384 |
| Molecular Weight | 41473.0 |
| Theoretical pI | 8.3 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>Urea transporter MDDNPTAVKLDQGGNQAPQGRGRRCLPKALGYITGDMKEFANWLKDKPQALQFVDWVLRG ISQVVFVSNPISGILILVGLLVQNPWCALNGCVGTVVSTLTALLLSQDRSAITAGLQGYN ATLVGILMAIYSDKGNYFWWLLFPVSAMSMTCPVFSSALNSVLSKWDLPVFTLPFNMALS MYLSATGHYNPFFPSTLITPVTSVPNVTWPDLSALQLLKSLPVGVGQIYGCDNPWTGGIF LGAILLSSPLMCLHAAIGSLLGIIAGLSLSAPFEDIYAGLWGFNSSLACIAIGGTFMALT WQTHLLALACALFTAYLGASMSHVMAVVGLPSGTWPFCLATLLFLLLTTKNPNIYKMPIS KVTYPEENRIFYLQSRKRTVQGPL |
| External Links | |
| GenBank ID Protein | AAU94647.1 |
| UniProtKB/Swiss-Prot ID | Q5QF96 |
| UniProtKB/Swiss-Prot Entry Name | UT1_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AY624602 |
| GeneCard ID | SLC14A1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |