Showing Protein Estrogen receptor (BMDBP02169)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02169 |
| Secondary Accession Numbers | None |
| Name | Estrogen receptor |
| Synonyms | Not Available |
| Gene Name | ESR1 |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in protein binding |
| Specific Function | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). |
| Pathways | Not Available |
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 9 |
| Locus | Not Available |
| SNPs | ESR1 |
| Gene Sequence |
>1791 bp ATGACCATGACCCTGCACACCAAAGCGTCCGGCATGGCCCTGCTGCACCAGATCCAAGCC AACGAGCTGGAGCCCCTGAACCGCCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGC GAGGTGTACATGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCGTAC GACTTCAACGCCGCGGCCCCCGCCTCCGCGCCCGTCTACGGCCAGTCGGGCCTCCCCTAC GGCCCCGGGTCCGAGGCGGCGGCGTTCGGCGCCAACGGCCTGGGGGCCTTCCCGCCGCTC AACAGCGTGTCTCCGAGCCCGCTGGTGCTGCTACACCCGCCTCCGCAGCCACTCTCGCCC TTCCTGCACCCGCACGGCCAACAGGTGCCCTATTACCTGGAGAACGAGTCGAGCGGCTAT GCGGTGCGCGAAGCCGGCCCTCCCGCCTACTACAGGCCAAATTCAGATAATCGACGCCAA GGTGGCAGAGAGAGATTGGCCAGTACCAGTGACAAGGGAAGCATGGCCATGGAATCTGCC AAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCCTCAGGCTACCATTACGGAGTT TGGTCTTGCGAGGGCTGTAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAATGACTAC ATGTGTCCGGCCACCAACCAGTGCACGATTGATAAAAACAGGAGGAAGAGCTGTCAGGCC TGCCGGCTACGCAAGTGCTATGAAGTGGGCATGATGAAAGGCGGAATACGGAAAGACCGA AGAGGAGGGAGAATGTTGAAGCACAAGCGCCAGAGAGATGATGGGGAGGGCAGGAACGAA GCGGTGCCCTCCGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCCATCATGATTAAA CACACTAAGAAGAACAGCCCGGTGTTGTCCCTGACAGCTGACCAGATGATCAGTGCCTTG CTGGAGGCTGAGCCCCCCATAATCTATTCTGAGTATGACCCTACCAGACCTTTCAGTGAG GCTTCAATGATGGGCTTGCTGACCAACCTTGCAGACAGGGAGCTGGTACACATGATCAAC TGGGCAAAGAGGGTGCCAGGATTTGTGGATCTGGCCCTCCATGATCAAGTCCACCTTTTG GAATGTGCCTGGCTAGAGATCCTCATGATTGGTCTTGTCTGGCGCTCCATGGAGCATCCA GGGAAGCTCCTATTTGCTCCTAACCTTCTCCTGGACAGGAACCAGGGAAAATGTGTGGAA GGCATGGTGGAGATCTTTGACATGTTGCTGGCTACTTCGTCTCGGTTCCGTATGATGAAT CTCCAGGGAGAAGAGTTTGTGTGCCTCAAATCCATCATCTTGCTTAATTCTGGAGTGTAC ACATTTCTGTCCAGCACTCTGAGGTCTCTGGAAGAGAAGGACCACATCCACCGCGTCCTG GACAAGATCACAGACACCTTGATCCATCTGATGGCCAAAGCAGGCCTGACTCTGCAGCAG CAGCACCGGCGTCTGGCCCAACTCCTCCTCATCCTCTCTCACTTCAGGCACATGAGCAAC AAAGGCATGGAGCATCTATACAGCATGAAGTGCAAGAACGTGGTGCCTCTCTACGACCTG CTGCTGGAGATGCTGGATGCCCACCGCCTGCACGCCCCAGCCAACTTTGGGAGCGCACCT CCAGAGGACGTGAATCAGAGCCAGCTGGCCCCCACTGGCTGCACTTCATCGCATTCCTTG CAAACATATTACATCACTGGGGAGGCAGAGAATTTCCCCAGCACAGTCTGA |
| Protein Properties | |
| Number of Residues | 596 |
| Molecular Weight | 66489.0 |
| Theoretical pI | 7.99 |
| Pfam Domain Function | Not Available |
| Signals |
|
| Transmembrane Regions | Not Available |
| Protein Sequence |
>Estrogen receptor MTMTLHTKASGMALLHQIQANELEPLNRPQLKIPLERPLGEVYMDSSKPAVYNYPEGAAY DFNAAAPASAPVYGQSGLPYGPGSEAAAFGANGLGAFPPLNSVSPSPLVLLHPPPQPLSP FLHPHGQQVPYYLENESSGYAVREAGPPAYYRPNSDNRRQGGRERLASTSDKGSMAMESA KETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQA CRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRNEAVPSGDMRAANLWPSPIMIK HTKKNSPVLSLTADQMISALLEAEPPIIYSEYDPTRPFSEASMMGLLTNLADRELVHMIN WAKRVPGFVDLALHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVE GMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLRSLEEKDHIHRVL DKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHFRHMSNKGMEHLYSMKCKNVVPLYDL LLEMLDAHRLHAPANFGSAPPEDVNQSQLAPTGCTSSHSLQTYYITGEAENFPSTV |
| External Links | |
| GenBank ID Protein | AAS46251.1 |
| UniProtKB/Swiss-Prot ID | P49884 |
| UniProtKB/Swiss-Prot Entry Name | ESR1_BOVIN |
| PDB IDs | |
| GenBank Gene ID | AY538775 |
| GeneCard ID | ESR1 |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |