| Identification |
|---|
| BMDB Protein ID
| BMDBP02173 |
| Secondary Accession Numbers
| None |
| Name
| Amiloride-sensitive sodium channel subunit alpha |
| Synonyms
|
Not Available
|
| Gene Name
| SCNN1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in amiloride-sensitive sodium channel activity |
| Specific Function
| Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| SCNN1A |
| Gene Sequence
|
>1953 bp
ATGAAGGGAGACAAGCCTGAGGAGCCGGGGCCGGGTCCCGAGCCTTCGGGCCCCCCGCCG
CCCACGGAGGAGGAGGAGGCCCTGCTCGAGTTCCACCGCTCCTACCGGGAGCTCTTCGAG
TTCTTCTGCAATAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCGCAGCACAAT
CGCATGAAGACAGTCTTCTGGGCCGTGCTCTGGCTCTGCACCTTCGGCATGATGTACTGG
CAGTTCGGCCAGCTCTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTC
AACTCGGACAAGCTTGTCTTCCCTGCGGTCTCCATCTGCACCCTAAACCCCTACAGGTAC
AAGGAAATTCAAGAGGAGCTGGAGGAGCTGGACCGCATCACGGAGCAGACTCTTTTCGAC
CTGTACAAGTACAACTCCTCCAAGACCCTCGTGGCCCACGCCCGCTCCCGCCGCGACCTG
CGGGAGCCGCTGCCGCACCCCCTTCAGCGCCTGCCCGTCCCGGCTCCGCCCCACGCGGCC
CGCGGAGTCCGCCGCGCCGGCTCCAGCATGCGGGACAACAACCCCCAGGTGAACAGGAAG
GACTGGAAGATCGGCTTCCAGCTGTGCAACCAGAACAAATCGGACTGCTTCTACCAGACG
TACTCGTCAGGGGTGGATGCTGTGAGAGAGTGGTACCGCTTCCACTACATCAACATTCTG
TCCAGACGGAGACAGGACACCTCTCCCTCGCTGGAGGAGGACGTGCTGGGCAAATTCATC
TTCACCTGCCGCTTCAACCAGGACTCCTGCAATGAGGCGAATTACTCTCATTTCCACCAC
CCGATGTATGGAAACTGCTACACTTTCAACGACAAGAACAGCTCCAACCTCTGGATGTCC
TCCATGCCCGGGGTCAACAACGGTCTGTCCCTGACACTGCGCACAGAGCAAAATGACTTC
ATCCCACTGCTGTCCACGGTGACCGGGGCCCGGGTGATGGTGCATGAACGGGATGAGCCT
GCCTTTATGGATGATGCTGGCTTTAATCTGCGGCCTGGCGTGGAGACCTCCATCAGCATG
AGTAAGGAAGCTGTGGACAGACTTGGGGGTGACTATGGCGACTGCACCAAGAATGGCAGC
GAGGTCCCAGTGGAGAACCTTTACAATACCAAGTACACGCAGCAGGTGTGCATCCATTCG
TGCTTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTACCCGCGGCCC
GACGGCGTAGAGTTCTGTGACTACAGGAAGCATAATTCCTGGGGCTACTGCTACTATAAG
CTCCAGGATGCCTTCTCCTCAGACCGCCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGC
AGTGTGACCATCTACAAGCTCTCTGCCAGTTACTCACAATGGCCGTCCGCGACATCCCAG
GACTGGGTCTTCCAGATGCTGTCCCGACAGAACAACTACACCATCAAGAACAAAAGGGAT
GGAGTTGCCAAACTCAACATCTTCTTCAAGGAGCTGAACTACAAATCTAATTCTGAGTCT
CCCTCAGTCACGATGGTCACGCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTC
GGCTCCTCCGTGCTGTCCGTGGTGGAGATGGCTGAGCTCATCATTGACCTCCTGGTTATC
ACCTTCCTCATGCTGCTCCGGAGGTTCCGAAGCCGATACTGGTCCCCAGGCCGAGGGGGC
AAGGGCACCCAGGAGGTGGCCTCCACTCCAGCCGCCTCCCTCCCCTCCAGTTTCTGCCCC
CACCCAGCTTTCTTCTCCTCATCCCCGCCAGACCCTGCCATCTCCCCGGCCTTGTCAGCC
CCTCCACCTGCCTATGCCACCCTGGGCCCCCACCCAGCTCCATCAGGCTTGGCAGAGGCC
AGCACCTCTGCCCACGCTCCGGGGGAGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 650 |
| Molecular Weight
| 73793.0 |
| Theoretical pI
| 7.16 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Amiloride-sensitive sodium channel subunit alpha
MKGDKPEEPGPGPEPSGPPPPTEEEEALLEFHRSYRELFEFFCNNTTIHGAIRLVCSQHN
RMKTVFWAVLWLCTFGMMYWQFGQLFGEYFSYPVSLNINLNSDKLVFPAVSICTLNPYRY
KEIQEELEELDRITEQTLFDLYKYNSSKTLVAHARSRRDLREPLPHPLQRLPVPAPPHAA
RGVRRAGSSMRDNNPQVNRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINIL
SRRRQDTSPSLEEDVLGKFIFTCRFNQDSCNEANYSHFHHPMYGNCYTFNDKNSSNLWMS
SMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHERDEPAFMDDAGFNLRPGVETSISM
SKEAVDRLGGDYGDCTKNGSEVPVENLYNTKYTQQVCIHSCFQESMIKECGCAYIFYPRP
DGVEFCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKPCSVTIYKLSASYSQWPSATSQ
DWVFQMLSRQNNYTIKNKRDGVAKLNIFFKELNYKSNSESPSVTMVTLLSNLGSQWSLWF
GSSVLSVVEMAELIIDLLVITFLMLLRRFRSRYWSPGRGGKGTQEVASTPAASLPSSFCP
HPAFFSSSPPDPAISPALSAPPPAYATLGPHPAPSGLAEASTSAHAPGEP
|
| External Links |
|---|
| GenBank ID Protein
| AAB48988.1 |
| UniProtKB/Swiss-Prot ID
| P55270 |
| UniProtKB/Swiss-Prot Entry Name
| SCNNA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U14944 |
| GeneCard ID
| SCNN1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
