| Identification |
|---|
| BMDB Protein ID
| BMDBP02174 |
| Secondary Accession Numbers
| None |
| Name
| Aquaporin-3 |
| Synonyms
|
Not Available
|
| Gene Name
| AQP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| AQP3 |
| Gene Sequence
|
>879 bp
ATGGGTCGACAGAAGGAGCTGGTGAACCGCTGCGGGGAGATGCTGCACATCCGCTACCGG
CTGCTCCGCCAGGCGCTGGCTGAGTGCCTGGGGACCCTCATCCTCGTGATGTTTGGCTGT
GGCTCTGTGGCCCAGGTCGTGCTCAGCCGGGGCACCCACGGTGGTTTCCTCACCATCAAC
CTGGCCTTTGGCTTCGCCGTGACCCTAGGCATCCTTATTGCTGGCCAGGTCTCTGGGGCC
CACCTGAACCCTGCCGTGACATTTGCTATGTGCTTCCTGGCGCGCGAGCCCTGGATCAAG
CTGCCTGTGTACACCTTGGCTCAGACTCTGGGAGCCTTCCTGGGCGCTGGAATTATCTTC
GGGTTGTATTACGATGCGATCTGGGCCTTCGCCAACAACCAGCTTATTGTTTCGGGCCCC
AATGGCACAGCTGGCATCTTTGCCACCTACCCCTCTGGACACTTGGACATGGTCAATGGC
TTCTTCGACCAGTTCATTGGCACAGCCTCCCTCATCGTGTGTGTGCTGGCCATTGTGGAC
CCCTACAACAACCCCGTCCCCCGAGGCCTAGAGGCCTTCACCGTGGGCCTGGTGGTCTTG
GTCATCGGTACCTCAATGGGCTTCAACTCTGGCTACGCCGTCAACCCCGCCCGGGACTTC
GGCCCCCGCCTTTTCACCGCCATCGCCGGCTGGGGCTCGGAAGTCTTCACGACGGGCCGC
CACTGGTGGTGGGTGCCCATTGTCTCTCCGCTCCTGGGTTCCATCGCCGGTGTCTTCGTG
TACCAGCTCATGATCGGCTGCCACCTGGAGCCGCCCCCACCCTCCACCGACGAGGAGAAT
GTGAAGTTGTCCCACGTGAAGCACAAGGAGCAGATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 292 |
| Molecular Weight
| 31518.0 |
| Theoretical pI
| 7.53 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 27-47
- 54-74
- 99-123
- 158-178
- 189-208
- 245-265
|
| Protein Sequence
|
>Aquaporin-3
MGRQKELVNRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTIN
LAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPVYTLAQTLGAFLGAGIIF
GLYYDAIWAFANNQLIVSGPNGTAGIFATYPSGHLDMVNGFFDQFIGTASLIVCVLAIVD
PYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTAIAGWGSEVFTTGR
HWWWVPIVSPLLGSIAGVFVYQLMIGCHLEPPPPSTDEENVKLSHVKHKEQM
|
| External Links |
|---|
| GenBank ID Protein
| AAI23792.1 |
| UniProtKB/Swiss-Prot ID
| Q08DE6 |
| UniProtKB/Swiss-Prot Entry Name
| AQP3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123791 |
| GeneCard ID
| AQP3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
