| Identification |
|---|
| BMDB Protein ID
| BMDBP02175 |
| Secondary Accession Numbers
| None |
| Name
| Aquaporin-4 |
| Synonyms
|
Not Available
|
| Gene Name
| AQP4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP. Plays a redundant role in urinary water homeostasis and urinary concentrating ability. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| AQP4 |
| Gene Sequence
|
>972 bp
ATGAGTGACAGACCCGCAGCGAGGCGGTGGGGTAAGTGTGGACCTTTGTGTACAAGAGAG
AGTATCATGGTGGCCTTCAAAGGGGTCTGGACACAAACTTTCTGGAAGGCAGTCACTGCG
GAATTTCTGGCCATGCTTATTTTTGTCCTGCTCAGCCTGGGATCCACCATCAACTGGGGT
GGAGCAGAAAAGCCACTACCTGTCGACATGGTTCTCATCTCCCTCTGCTTTGGACTCAGC
ATCGCGACTATGGTCCAGTGCTTTGGCCACATCAGTGGTGGCCACATCAACCCCGCTGTG
ACGGTGGCCATGGTGTGCACCAGGAGGATTAGCATCGCCAAGTCTGTCTTCTACATTGCA
GCTCAGTGCCTGGGCGCCATCATTGGAGCCGGAATTCTCTACCTGGTCACGCCTCCCAGT
GTGGTAGGGGGCCTTGGAGTCACCACGGTTCACGGAAATCTTAGCGCTGGACACGGTCTC
CTGGTGGAGTTGATAATCACATTTCAGTTGGTGTTTACTATTTTTGCCAGCTGTGATTCC
AAACGGACTGATGTCACCGGTTCCATAGCTTTAGCCATTGGGATCTCTGTTGCAATTGGA
CATTTATTTGCAATCAATTACACTGGTGCCAGCATGAACCCCGCCCGATCCTTTGGACCT
GCAGTTATCATGGGAAATTGGGAGAACCACTGGATATATTGGGTTGGACCAATCATAGGA
GCTGTCCTTGCTGGTGGCCTCTATGAGTATGTCTTCTGTCCAGATGTTGAACTCAAACGT
CGATTTAAAGAAGCCTTCAGCAAAGCTGCCCAGCAAACAAAAGGGAGCTACATGGAGGTG
GAGGACAACAGGAGTCAGGTAGAGACCGACGACTTGATTCTAAAACCCGGAGTGGTGCAC
GTGATCGACATTGACCGGGGGGAGGAGAAGAAAGGGAAAGACCCATCTGGAGAGGTGTTG
TCTTCAGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 323 |
| Molecular Weight
| 34672.0 |
| Theoretical pI
| 7.75 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 37-57
- 70-89
- 116-136
- 156-176
- 185-205
- 232-252
|
| Protein Sequence
|
>Aquaporin-4
MSDRPAARRWGKCGPLCTRESIMVAFKGVWTQTFWKAVTAEFLAMLIFVLLSLGSTINWG
GAEKPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRRISIAKSVFYIA
AQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLSAGHGLLVELIITFQLVFTIFASCDS
KRTDVTGSIALAIGISVAIGHLFAINYTGASMNPARSFGPAVIMGNWENHWIYWVGPIIG
AVLAGGLYEYVFCPDVELKRRFKEAFSKAAQQTKGSYMEVEDNRSQVETDDLILKPGVVH
VIDIDRGEEKKGKDPSGEVLSSV
|
| External Links |
|---|
| GenBank ID Protein
| BAA36505.2 |
| UniProtKB/Swiss-Prot ID
| O77750 |
| UniProtKB/Swiss-Prot Entry Name
| AQP4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB015947 |
| GeneCard ID
| AQP4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
