| Identification |
|---|
| BMDB Protein ID
| BMDBP02183 |
| Secondary Accession Numbers
| None |
| Name
| Guanine nucleotide-binding protein G(t) subunit alpha-1 |
| Synonyms
|
Not Available
|
| Gene Name
| GNAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyl binding |
| Specific Function
| Functions as signal transducer for the rod photoreceptor RHO (PubMed:21285355, PubMed:23303210, PubMed:28655769, PubMed:8259210). Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21285355, PubMed:28655769, PubMed:8259210, PubMed:8208289, PubMed:7969474). Activated RHO promotes GDP release and GTP binding (PubMed:21285355, PubMed:28655769). Signaling is mediated via downstream effector proteins, such as cGMP-phosphodiesterase (PubMed:21285355). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| GNAT1 |
| Gene Sequence
|
>1053 bp
CCTTCACCTCCTGCCAGGACCATGGGGGCTGGGGCCAGCGCTGAGGAGAAGCACTCAAGG
GAGCTGGAAAAGAAGCTGAAAGAAGATGCTGAGAAAGATGCTCGAACCGTGAAACTGCTG
CTTCTGGGTGCCGGTGAATCCGGGAAGAGTACCATTGTCAAGCAGATGAAGATTATCCAC
CAGGACGGGTACTCACTGGAAGAGTGTCTTGAGTTCATTGCCATCATCTATGGCAACACG
CTACAGTCCATCCTGGCCATTGTGCGCGCCATGACCACACTCAACATCCAGTACGGAGAC
TCTGCGCGCCAGGACGACGCCCGAAAGCTGATGCACATGGCAGACACCATCGAGGAGGGC
ACGATGCCCAAGGAGATGTCAGACATCATCCAGCGGCTGTGGAAGGACTCCGGTATCCAG
GCCTGTTTCGACCGAGCCTCAGAGTACCAGCTCAACGACTCTGCTGGCTACTATCTCTCA
GACCTGGAGCGCCTGGTAACCCCGGGCTACGTGCCCACTGAACAGGATGTGCTGCGCTCC
CGTGTCAAGACCACGGGTATCATTGAGACGCAGTTCTCCTTCAAGGACCTCAACTTTCGG
ATGTTCGATGTGGGCGGGCAGCGCTCAGAGCGCAAGAAGTGGATCCACTGCTTCGAGGGG
GTGACCTGCATCATCTTCATCGCGGCGCTGAGCGCCTACGACATGGTGCTGGTGGAAGAC
GACGAAGTGAACCGCATGCACGAGAGCCTGCACCTGTTCAACAGTATCTGCAACCACCGC
TACTTCGCCACCACGTCCATCGTGCTCTTTCTCAACAAGAAGGACGTCTTCTCGGAGAAG
ATCAAAAAGGCGCACCTTAGCATCTGCTTTCCGGACTACAACGGGCCCAACACGTATGAG
GACGCCGGCAATTACATCAAGGTGCAATTCCTTGAGCTCAACATGCGACGCGACGTGAAG
GAGATCTATTCCCACATGACATGCGCCACCGACACGCAGAACGTCAAGTTTGTCTTCGAC
GCTGTCACCGACATCATCATCAAGGAGAACCTC
|
| Protein Properties |
|---|
| Number of Residues
| 350 |
| Molecular Weight
| 39966.0 |
| Theoretical pI
| 5.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Guanine nucleotide-binding protein G(t) subunit alpha-1
MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLE
ECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMS
DIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGI
IETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMH
ESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKKAHLSICFPDYNGPNTYEDAGNYIK
VQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
|
| External Links |
|---|
| GenBank ID Protein
| AAA30787.1 |
| UniProtKB/Swiss-Prot ID
| P04695 |
| UniProtKB/Swiss-Prot Entry Name
| GNAT1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| K03253 |
| GeneCard ID
| GNAT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
