| Identification |
|---|
| BMDB Protein ID
| BMDBP02194 |
| Secondary Accession Numbers
| None |
| Name
| Guanine nucleotide-binding protein G(i) subunit alpha-1 |
| Synonyms
|
Not Available
|
| Gene Name
| GNAI1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| GNAI1 |
| Gene Sequence
|
>1065 bp
ATGGGCTGTACGCTGAGCGCCGAGGACAAGGCGGCGGTGGAGCGGAGTAAGATGATCGAC
CGGAACCTCCGCGAGGATGGCGAGAAGGCGGCGCGCGAGGTCAAGCTGCTGCTGCTCGGT
GCTGGTGAATCTGGGAAAAGTACAATTGTGAAGCAAATGAAAATTATCCATGAAGCTGGT
TATTCAGAAGAGGAATGTAAGCAGTACAAAGCTGTGGTCTACAGTAACACCATCCAGTCA
ATTATCGCTATCATTAGGGCCATGGGGAGATTGAAGATTGACTTCGGTGACTCAGCCCGG
GCGGATGATGCCCGCCAACTCTTTGTGCTTGCTGGCGCTGCAGAGGAAGGTTTTATGACT
GCAGAACTTGCTGGAGTTATAAAGAGACTTTGGAAAGACAGTGGTGTACAAGCCTGCTTC
AACAGATCCCGAGAGTACCAGCTTAATGATTCTGCAGCATACTATTTGAATGATTTGGAC
AGAATTGCACAACCAAATTATATTCCAACTCAACAAGATGTTCTCAGAACTCGAGTGAAA
ACCACAGGAATTGTTGAGACCCATTTTACTTTCAAAGATCTTCATTTTAAAATGTTTGAT
GTGGGAGGACAGAGATCTGAGCGGAAGAAATGGATTCATTGCTTCGAAGGAGTGACCGCC
ATCATCTTCTGTGTGGCGCTGAGTGACTATGACCTGGTTCTAGCTGAAGATGAAGAAATG
AACCGAATGCATGAAAGCATGAAGTTATTCGACAGCATATGTAACAACAAATGGTTTACA
GATACATCTATTATACTTTTTCTGAACAAGAAGGATCTCTTTGAAGAAAAAATCAAGAAG
AGCCCTCTCACTATATGCTATCCAGAATATGCAGGCTCAAACACATATGAAGAGGCAGCT
GCGTACATTCAGTGTCAGTTTGAAGACCTCAATAAGAGAAAGGACACAAAGGAAATATAC
ACCCACTTCACGTGCGCCACGGACACCAAGAACGTGCAGTTCGTCTTTGATGCCGTAACA
GACGTCATCATAAAAAATAACCTAAAAGACTGTGGTCTCTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 40361.0 |
| Theoretical pI
| 5.76 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 211-232
- 261-284
- 305-326
- 359-379
- 391-412
- 432-454
|
| Protein Sequence
|
>Guanine nucleotide-binding protein G(i), alpha-1 subunit
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
|
| External Links |
|---|
| GenBank ID Protein
| CAA27288.1 |
| UniProtKB/Swiss-Prot ID
| P63097 |
| UniProtKB/Swiss-Prot Entry Name
| GNAI1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X03642 |
| GeneCard ID
| GNAI1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
