Showing Protein 5-hydroxytryptamine receptor 2A (BMDBP02223)
| Identification | |
|---|---|
| BMDB Protein ID | BMDBP02223 |
| Secondary Accession Numbers | None |
| Name | 5-hydroxytryptamine receptor 2A |
| Synonyms | Not Available |
| Gene Name | HTR2A |
| Protein Type | Enzyme |
| Biological Properties | |
| General Function | Involved in G-protein coupled receptor activity |
| Specific Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). |
| Pathways |
|
| Reactions | Not Available |
| GO Classification | Not Available |
| Cellular Location | Not Available |
| Gene Properties | |
| Chromosome Location | 12 |
| Locus | Not Available |
| SNPs | HTR2A |
| Gene Sequence |
>1413 bp ATGGATATTCTCTGTGAAGAAAACACTTCTTTGAGCTCAACTACGAACTCCTTAATGCAA TTACATGCTGACACAAGGCTCTACAGTACTGACTTTAACTCCGGAGAAGGTAACACTTCG AATGCATTTAACTGGACCGTGGACTCAGAAAATCGAACCAACCTTTCCTGTGAGGGCTGT CTCTCACCACCCTGCTTCTCCTTACTTCATCTCCAGGAAAAGAACTGGTCTGCTCTGTTG ACAGCGGTAGTGATTATACTAACCATTGCCGGAAACATACTCGTCATCATGGCAGTGTCC CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTCGCCATAGCTGAT ATGCTGCTGGGTTTCCTGGTCATGCCCGTGTCCACGTTAACCATCCTCTATGGGTACCGG TGGCCTCTGCCCAGCAAGCTCTGCGCTGTTTGGATTTACCTGGATGTGCTCTTCTCCACG GCCTCCATCATGCATCTGTGTGCTATCTCCCTGGACCGCTATGTTGCCATTCAGAACCCC ATCCATCACAGCCGGTTCAACTCCAGAACTAAGGCATTTCTGAAAATAATTGCTGTTTGG ACGATATCAGTGGGTATATCCATGCCAATACCAGTCTTTGGGCTCCAGGACGATTCCAAA GTCTTTAAGGAAGGGAGTTGCTTACTCGCGGATGAGAACTTTGTCCTGATTGGCTCTTTC GTGGCCTTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTCACCATCAAGTCG CTCCAGAAAGAAGCCACTTTGTGTGTGAGTGATCCTGGAACACGGACCAAATTAGCTTCT TTCAGCTTCCTGCCTCAGAGCTCCCTGTCTTCGGAAAAGCTCTTCCAGCGGTCCATCCAC AGGGAGCCAGGCTCCTACGGCAGGAGGACTATGCAGTCCATCAGCAACGAGCAGAAGGCT TGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCCTTCTTCATC ACCAACATAATGGCTGTCATCTGCAAAGAGTCCTGCAACAGGGATGTCATCGAAGCCCTG CTCAACGTGTTCGTTTGGATCGGTTACCTCTCCTCAGCAGTCAACCCGCTGGTGTATACA CTGTTCAATAAGACCTATAGGTCTGCCTTTTCCAGGTATATTCAGTGTCAGTACAAGGAA AATAAAAAACCATTGCAGTTAATTTTAGTGAACACTATCCCGGCCTTGGCTTATAAGTCC AGTCAACTCCAAATGGGACCTAAAAAGAATTCGAAGAAAGATGACAAGACGACAGATAAT GACTGCACTATGGTTGCTCTAGGAAAAGAGCATCCCGAAGATGCTCCTGCAGACAGTAGC AACACAGTGAACGAAAAGGTTAGCTGTGTCTGA |
| Protein Properties | |
| Number of Residues | 470 |
| Molecular Weight | 52571.0 |
| Theoretical pI | 8.03 |
| Pfam Domain Function | Not Available |
| Signals |
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| Transmembrane Regions |
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| Protein Sequence |
>5-hydroxytryptamine receptor 2A MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGC LSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD MLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSF VAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIH REPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEAL LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKS SQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV |
| External Links | |
| GenBank ID Protein | BAD12238.1 |
| UniProtKB/Swiss-Prot ID | Q75Z89 |
| UniProtKB/Swiss-Prot Entry Name | 5HT2A_BOVIN |
| PDB IDs | Not Available |
| GenBank Gene ID | AB119637 |
| GeneCard ID | HTR2A |
| GenAtlas ID | Not Available |
| HGNC ID | Not Available |
| References | |
| General References | Not Available |