| Identification |
|---|
| BMDB Protein ID
| BMDBP02237 |
| Secondary Accession Numbers
| None |
| Name
| CD44 antigen |
| Synonyms
|
Not Available
|
| Gene Name
| CD44 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hyaluronic acid binding |
| Specific Function
| Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| CD44 |
| Gene Sequence
|
>1101 bp
ATGGACACGTTTTGGTGGCGCGCAGCCTGGGGACTCTGCCTCGTGCAGCTGAGCCTGGCG
CAGATCGATCTGAATATAACCTGCCGATATGCAGGTGTATTCCACGTGGAGAAGAATGGT
CGCTATAGCATCTCTAAGACTGAGGCTGCTGACCTCTGCAAGGCCTTTAATAGCACGCTG
CCCACCATGGCCCAGATGGAGGCGGCCCGGAACATAGGGTTTGAGACCTGCAGGTACGGG
TTCATAGAAGGGCATGTGGTGATTCCCCGGATCCACCCCAATTCCATCTGTGCTGCGAAC
AACACGGGGGTGTACATCCTCACATCCAACACCTCCCAGTATGACACGATCTGCTTCAAT
GCCTCAGCTCCACCTGGGGAAGACTGTACATCGGTCACGGACCTGCCCAATGCCTTTGAA
GGACCAATTACCATAACTATTGTAAACCGTGATGGCACCCGTTATACCAAGAAAGGCGAA
TACAGAACTAACCCAGAAGACATCAACCCCAGCGTCGTTAGCCCCAGCAGCCCTCCTGAC
GATGAGATGAGCAGCGGCTCCCCCAGTGAGAGAAGCACTTCAGGAGGCTACAGCATCTTC
CACACGCACCTCCCAACTGTGCACCCGTCCAGACCAAGACGGCCCTGGTCTCAGCGAGCA
GAGAATACCTCGGATACCAGAGACTACGGCTCGTCCCACGACCCCAGTGGAAGATCCTAT
ACAACTCACGCATCTGAATCAGCTGGACACTCAAGTGGGAGTGAAGAACATGGGGCAAAC
ACAACCTCAGGTCCTATGCGGAAACCTCAAATTCCAGAATGGCTGATCATCTTGGCATCT
CTCCTGGCCTTGGCTTTGATTCTCGCGGTTTGCATTGCTGTCAACAGTAGGAGAAGGTGT
GGGCAGAAGAAAAAACTGGTGATCAACAATGGGAATGGAACCATGGAGGAGAGAAAGCCC
AGCGGACTCAACGGAGAAGCTAGCAAGTCTCAGGAGATGGTGCATTTGGTGAACAAGGGG
TCGTCAGAGACCCCAGACCAGTTCATGACGGCAGATGAGACGCGGAACTTGCAGAATGTG
GATATGAAGATTGGGGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 366 |
| Molecular Weight
| 40002.0 |
| Theoretical pI
| 6.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>CD44 antigen
MDTFWWRAAWGLCLVQLSLAQIDLNITCRYAGVFHVEKNGRYSISKTEAADLCKAFNSTL
PTMAQMEAARNIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTICFN
ASAPPGEDCTSVTDLPNAFEGPITITIVNRDGTRYTKKGEYRTNPEDINPSVVSPSSPPD
DEMSSGSPSERSTSGGYSIFHTHLPTVHPSRPRRPWSQRAENTSDTRDYGSSHDPSGRSY
TTHASESAGHSSGSEEHGANTTSGPMRKPQIPEWLIILASLLALALILAVCIAVNSRRRC
GQKKKLVINNGNGTMEERKPSGLNGEASKSQEMVHLVNKGSSETPDQFMTADETRNLQNV
DMKIGV
|
| External Links |
|---|
| GenBank ID Protein
| CAA44675.1 |
| UniProtKB/Swiss-Prot ID
| Q29423 |
| UniProtKB/Swiss-Prot Entry Name
| CD44_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X62881 |
| GeneCard ID
| CD44 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
