Identification |
BMDB Protein ID
| BMDBP02237 |
Secondary Accession Numbers
| None |
Name
| CD44 antigen |
Synonyms
|
Not Available
|
Gene Name
| CD44 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in hyaluronic acid binding |
Specific Function
| Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. |
Pathways
|
Not Available
|
Reactions
| Not Available |
GO Classification
|
Not Available
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| 15 |
Locus
| Not Available |
SNPs
| CD44 |
Gene Sequence
|
>1101 bp
ATGGACACGTTTTGGTGGCGCGCAGCCTGGGGACTCTGCCTCGTGCAGCTGAGCCTGGCG
CAGATCGATCTGAATATAACCTGCCGATATGCAGGTGTATTCCACGTGGAGAAGAATGGT
CGCTATAGCATCTCTAAGACTGAGGCTGCTGACCTCTGCAAGGCCTTTAATAGCACGCTG
CCCACCATGGCCCAGATGGAGGCGGCCCGGAACATAGGGTTTGAGACCTGCAGGTACGGG
TTCATAGAAGGGCATGTGGTGATTCCCCGGATCCACCCCAATTCCATCTGTGCTGCGAAC
AACACGGGGGTGTACATCCTCACATCCAACACCTCCCAGTATGACACGATCTGCTTCAAT
GCCTCAGCTCCACCTGGGGAAGACTGTACATCGGTCACGGACCTGCCCAATGCCTTTGAA
GGACCAATTACCATAACTATTGTAAACCGTGATGGCACCCGTTATACCAAGAAAGGCGAA
TACAGAACTAACCCAGAAGACATCAACCCCAGCGTCGTTAGCCCCAGCAGCCCTCCTGAC
GATGAGATGAGCAGCGGCTCCCCCAGTGAGAGAAGCACTTCAGGAGGCTACAGCATCTTC
CACACGCACCTCCCAACTGTGCACCCGTCCAGACCAAGACGGCCCTGGTCTCAGCGAGCA
GAGAATACCTCGGATACCAGAGACTACGGCTCGTCCCACGACCCCAGTGGAAGATCCTAT
ACAACTCACGCATCTGAATCAGCTGGACACTCAAGTGGGAGTGAAGAACATGGGGCAAAC
ACAACCTCAGGTCCTATGCGGAAACCTCAAATTCCAGAATGGCTGATCATCTTGGCATCT
CTCCTGGCCTTGGCTTTGATTCTCGCGGTTTGCATTGCTGTCAACAGTAGGAGAAGGTGT
GGGCAGAAGAAAAAACTGGTGATCAACAATGGGAATGGAACCATGGAGGAGAGAAAGCCC
AGCGGACTCAACGGAGAAGCTAGCAAGTCTCAGGAGATGGTGCATTTGGTGAACAAGGGG
TCGTCAGAGACCCCAGACCAGTTCATGACGGCAGATGAGACGCGGAACTTGCAGAATGTG
GATATGAAGATTGGGGTGTAA
|
Protein Properties |
Number of Residues
| 366 |
Molecular Weight
| 40002.0 |
Theoretical pI
| 6.89 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>CD44 antigen
MDTFWWRAAWGLCLVQLSLAQIDLNITCRYAGVFHVEKNGRYSISKTEAADLCKAFNSTL
PTMAQMEAARNIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTICFN
ASAPPGEDCTSVTDLPNAFEGPITITIVNRDGTRYTKKGEYRTNPEDINPSVVSPSSPPD
DEMSSGSPSERSTSGGYSIFHTHLPTVHPSRPRRPWSQRAENTSDTRDYGSSHDPSGRSY
TTHASESAGHSSGSEEHGANTTSGPMRKPQIPEWLIILASLLALALILAVCIAVNSRRRC
GQKKKLVINNGNGTMEERKPSGLNGEASKSQEMVHLVNKGSSETPDQFMTADETRNLQNV
DMKIGV
|
External Links |
GenBank ID Protein
| CAA44675.1 |
UniProtKB/Swiss-Prot ID
| Q29423 |
UniProtKB/Swiss-Prot Entry Name
| CD44_BOVIN |
PDB IDs
|
Not Available |
GenBank Gene ID
| X62881 |
GeneCard ID
| CD44 |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| Not Available |