Identification
BMDB Protein ID BMDBP02237
Secondary Accession Numbers None
Name CD44 antigen
Synonyms Not Available
Gene Name CD44
Protein Type Enzyme
Biological Properties
General Function Involved in hyaluronic acid binding
Specific Function Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion.
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location Not Available
Gene Properties
Chromosome Location 15
Locus Not Available
SNPs CD44
Gene Sequence
>1101 bp
ATGGACACGTTTTGGTGGCGCGCAGCCTGGGGACTCTGCCTCGTGCAGCTGAGCCTGGCG
CAGATCGATCTGAATATAACCTGCCGATATGCAGGTGTATTCCACGTGGAGAAGAATGGT
CGCTATAGCATCTCTAAGACTGAGGCTGCTGACCTCTGCAAGGCCTTTAATAGCACGCTG
CCCACCATGGCCCAGATGGAGGCGGCCCGGAACATAGGGTTTGAGACCTGCAGGTACGGG
TTCATAGAAGGGCATGTGGTGATTCCCCGGATCCACCCCAATTCCATCTGTGCTGCGAAC
AACACGGGGGTGTACATCCTCACATCCAACACCTCCCAGTATGACACGATCTGCTTCAAT
GCCTCAGCTCCACCTGGGGAAGACTGTACATCGGTCACGGACCTGCCCAATGCCTTTGAA
GGACCAATTACCATAACTATTGTAAACCGTGATGGCACCCGTTATACCAAGAAAGGCGAA
TACAGAACTAACCCAGAAGACATCAACCCCAGCGTCGTTAGCCCCAGCAGCCCTCCTGAC
GATGAGATGAGCAGCGGCTCCCCCAGTGAGAGAAGCACTTCAGGAGGCTACAGCATCTTC
CACACGCACCTCCCAACTGTGCACCCGTCCAGACCAAGACGGCCCTGGTCTCAGCGAGCA
GAGAATACCTCGGATACCAGAGACTACGGCTCGTCCCACGACCCCAGTGGAAGATCCTAT
ACAACTCACGCATCTGAATCAGCTGGACACTCAAGTGGGAGTGAAGAACATGGGGCAAAC
ACAACCTCAGGTCCTATGCGGAAACCTCAAATTCCAGAATGGCTGATCATCTTGGCATCT
CTCCTGGCCTTGGCTTTGATTCTCGCGGTTTGCATTGCTGTCAACAGTAGGAGAAGGTGT
GGGCAGAAGAAAAAACTGGTGATCAACAATGGGAATGGAACCATGGAGGAGAGAAAGCCC
AGCGGACTCAACGGAGAAGCTAGCAAGTCTCAGGAGATGGTGCATTTGGTGAACAAGGGG
TCGTCAGAGACCCCAGACCAGTTCATGACGGCAGATGAGACGCGGAACTTGCAGAATGTG
GATATGAAGATTGGGGTGTAA
Protein Properties
Number of Residues 366
Molecular Weight 40002.0
Theoretical pI 6.89
Pfam Domain Function Not Available
Signals
  • 1-20
Transmembrane Regions
  • 274-294
Protein Sequence
>CD44 antigen
MDTFWWRAAWGLCLVQLSLAQIDLNITCRYAGVFHVEKNGRYSISKTEAADLCKAFNSTL
PTMAQMEAARNIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTICFN
ASAPPGEDCTSVTDLPNAFEGPITITIVNRDGTRYTKKGEYRTNPEDINPSVVSPSSPPD
DEMSSGSPSERSTSGGYSIFHTHLPTVHPSRPRRPWSQRAENTSDTRDYGSSHDPSGRSY
TTHASESAGHSSGSEEHGANTTSGPMRKPQIPEWLIILASLLALALILAVCIAVNSRRRC
GQKKKLVINNGNGTMEERKPSGLNGEASKSQEMVHLVNKGSSETPDQFMTADETRNLQNV
DMKIGV
GenBank ID Protein CAA44675.1
UniProtKB/Swiss-Prot ID Q29423
UniProtKB/Swiss-Prot Entry Name CD44_BOVIN
PDB IDs Not Available
GenBank Gene ID X62881
GeneCard ID CD44
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available